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Aging increases the susceptibility to develop anhedonia in male rats

dc.creatorHerrera-Pérez, Jaime
dc.creatorMartínez-Mota, Lucía
dc.creatorFernández-Guasti, Alonso
dc.date.accessioned2017-06-30T03:43:04Z
dc.date.available2017-06-30T03:43:04Z
dc.date.issued2008es_ES
dc.identifier2166es_ES
dc.identifier.issn0278-5846es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/6815
dc.identifier.urihttps://doi.org/10.1016/j.pnpbp.2008.07.020es_ES
dc.language.isoenges_ES
dc.publisherPERGAMON-ELSEVIER SCIENCE LTD, THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLANDes_ES
dc.relation32, 1798-1803 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.subject.meshAnalysis of variancees_ES
dc.subject.meshAnimalses_ES
dc.subject.meshChronic diseasees_ES
dc.subject.meshConditioning, operant-Physiologyes_ES
dc.subject.meshCorticosterone-Bloodes_ES
dc.subject.meshDepression-Bloodes_ES
dc.subject.meshDepression-Etiologyes_ES
dc.subject.meshDisease susceptibilityes_ES
dc.subject.meshDrinkng-Physiologyes_ES
dc.subject.meshEating-Physiologyes_ES
dc.subject.meshEstradiol-Bloodes_ES
dc.subject.meshFood preferenceses_ES
dc.subject.meshMalees_ES
dc.subject.meshRats, Wistares_ES
dc.subject.meshStress, Psychological-Complicationses_ES
dc.subject.meshTestosterone-Bloodes_ES
dc.titleAging increases the susceptibility to develop anhedonia in male ratses_ES
dc.typearticlees_ES
dc.contributor.affiliationFarmacología Conductual, Dirección de Investigaciones en Neurociencias, Instituto Nacional de Psiquiatría “Ramón de la Fuente Muñiz”, Calzada México-Xochimilco 101, Col. San Lorenzo Huipulco, Tlalpan, CP: 14370, Mexico City, Mexicoes_ES
dc.contributor.emailjfernand@cinvestav.mxes_ES
dc.relation.jnabreviadoPROG NEUROPSYCHOPHARMACOL BIOL PSYCHIATRYes_ES
dc.relation.journalProgress in neuro-psychopharmacology & biological psychiatryes_ES
dc.identifier.placeOxfordes_ES
dc.date.published2008es_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, México.es_ES
dc.identifier.eissn1878-4216es_ES
dc.identifier.doi10.1016/j.pnpbp.2008.07.020es_ES
dc.description.monthJules_ES
dc.description.abstractotrodiomaThe objective of this study was to establish the effect of aging on the development of anhedonia, a core feature of depression. Young and old male Wistar rats (of around 3–5 and 12–15 months, respectively) were exposed to a chronic variable stress (CVS) schedule for 3 weeks. CVS produced anhedonia, indicated by a reduction in the intake of a sucrose solution (1%), in 8 out of 23 (35%) young rats and in 19 out of 26 (73%) old rats, implying that old animals are more susceptible to stress and develop anhedonia more readily than young animals. Young and old anhedonic rats showed a similar temporal course in the reduction of sucrose consumption, reaching the anhedonic state after 2 weeks of CVS exposure. Compared with young animals, old rats had lower basal serum testosterone and estradiol levels. The systemic levels of corticosterone did not vary between both age groups. No significant pathological condition was detected in old animals. It is suggested that the higher susceptibility to develop anhedonia in male rats could be associated to neuroendocrine changes consequent to aging.es_ES
dc.subject.kwEnvejecimientoes_ES
dc.subject.kwAnhedoniaes_ES
dc.subject.kwEstrés crónicoes_ES
dc.subject.kwDepressiones_ES
dc.subject.kwResistenciaes_ES
dc.subject.koAginges_ES
dc.subject.koAnhedoniaes_ES
dc.subject.koChronic stresses_ES
dc.subject.koDepresiónes_ES
dc.subject.koResiliencees_ES


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