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Treatment with BB-94, a broad spectrum inhibitor of zinc-dependent metalloproteinases, causes deviation of the cytokine profile towards Type-2 in experimental pulmonary tuberculosis in Balb/c mice

dc.creatorHernández-Pando, Rogelio
dc.creatorOrozco, Héctor
dc.creatorArriaga, Kutzi
dc.creatorPavón, Lenin
dc.creatorRook, Graham
dc.date.accessioned2017-06-30T03:43:02Z
dc.date.available2017-06-30T03:43:02Z
dc.date.issued2000es_ES
dc.identifier2164es_ES
dc.identifier.issn0959-9673es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/6814
dc.identifier.urihttps://doi.org/10.1046/j.1365-2613.2000.00152.xes_ES
dc.identifier.urihttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2517727/es_ES
dc.language.isoenges_ES
dc.publisherWiley-Blackwell, Commerce Place, 350 Main ST, Malden 02148, MA USAes_ES
dc.relation81 (3) 199-209 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.subject.meshMatrix-metalloproteinasees_ES
dc.subject.meshTumor-necrosis-factores_ES
dc.subject.meshFactor Alphaes_ES
dc.subject.meshMycobacterium tuberculosises_ES
dc.subject.meshPancreatic-canceres_ES
dc.subject.meshBatimastat BB-94es_ES
dc.subject.meshTNF-Alphaes_ES
dc.subject.meshExpressiones_ES
dc.subject.meshCelles_ES
dc.subject.meshPathogenesises_ES
dc.titleTreatment with BB-94, a broad spectrum inhibitor of zinc-dependent metalloproteinases, causes deviation of the cytokine profile towards Type-2 in experimental pulmonary tuberculosis in Balb/c micees_ES
dc.typearticlees_ES
dc.contributor.affiliationRoyal Free & UCL, Sch Med, Dept Bacteriol, 46 Cleveland St, London W1P 6DB, England.es_ES
dc.contributor.emailg.rook@ucl.ac.ukes_ES
dc.relation.jnabreviadoINT J EXP PATHOLes_ES
dc.relation.journalInternational journal of experimental pathologyes_ES
dc.identifier.placeMaldenes_ES
dc.date.published2000es_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, México.es_ES
dc.identifier.eissn1365-2613es_ES
dc.identifier.doi10.1046/j.1365-2613.2000.00152.x   es_ES
dc.description.monthJunes_ES
dc.description.abstractotrodiomaBB-94 (batimastat) is a broad- spectrum hydroxamic acid-based zinc metalloproteinase inhibitor that inhibits both the matrix metalloproteinases (MMP) and members of the ADAM family of enzymes such as Tumour Necrosis Factor-alpha Cleaving Enzyme (TACE). These enzymes are involved in the regulation of inflammatory processes in tuberculosis. Balb/c mice infected with M. tuberculosis via the intratracheal route were treated with BB-94 for 1 month, starting on the day of infection. Immunohistochemistry, semiquantitative RT-PCR and ELISA assays for cytokines revealed a deficit in IL-1 and IL-2 expression and a premature bias towards IL-4 expression, accompanied by a delay in granuloma formation and more rapid progression of disease in BB-94-treated animals. This situation corrected itself after the drug was withdrawn at 28 days. In contrast, when BB-94 was administered only after 1 month there were no significant changes apart from the presence of amyloid, and a paradoxically increased expression of IL-1 alpha. These results cast light on mechanisms of immunity in tuberculosis and also indicate that in patients treated with similar broad-spectrum MMP inhibitors there may be a risk of inappropriate deviation of some immune responses towards a Type-2 cytokine profile.es_ES
dc.subject.kwMetaloproteinasas de matrizes_ES
dc.subject.kwTuberculosises_ES
dc.subject.kwPerfil de citoquinases_ES
dc.subject.koMatrix metalloproteinaseses_ES
dc.subject.koTuberculosises_ES
dc.subject.koCytokine profilees_ES


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