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Correlation between the kinetics of Th1/Th2 cells and pathology in a murine model of experimental pulmonary tuberculosis

dc.creatorHernández Pando, R.
dc.creatorOrozcoe, H.
dc.creatorSampieri, A.
dc.creatorPavón, L.
dc.creatorVelasquillo, C.
dc.creatorLarriva-Sahd, J.
dc.creatorAlcocer, J.M.
dc.creatorMadrid, M.V.
dc.date.accessioned2017-06-30T03:43:00Z
dc.date.available2017-06-30T03:43:00Z
dc.date.issued1996es_ES
dc.identifier2163es_ES
dc.identifier.issn0019-2805es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/6813
dc.identifier.urihttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1456655/es_ES
dc.language.isoenges_ES
dc.publisherBLACKWELL SCIENCE LTD, OSNEY MEAD, OXFORD, OXON, ENGLAND OX2 0ELes_ES
dc.relation89 (1) 26-33 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.titleCorrelation between the kinetics of Th1/Th2 cells and pathology in a murine model of experimental pulmonary tuberculosises_ES
dc.typearticlees_ES
dc.contributor.affiliationInstituto Nacional de la Nutrición 'Salvador Zubiran', Calle Vasco de Quiroga 15, Delagacion Tlalpan, 14000, Mexico DF.es_ES
dc.relation.jnabreviadoIMMUNOLOGYes_ES
dc.relation.journalImmunologyes_ES
dc.identifier.placeOxford, Englandes_ES
dc.date.published1996es_ES
dc.identifier.organizacionInstituto Mexicano de Psiquiatríaes_ES
dc.identifier.eissn1365-2567es_ES
dc.description.monthSep-Octes_ES
dc.description.abstractotrodiomaT-helper 1 (Th1)/Th2 kinetics were studied by immunohistochemistry and molecular biology techniques (reverse transcriptase-polymerase chain reaction: RT-PCR, Southern-blot) during the course of pulmonary tuberculosis induced in BALB/c mice by the intratracheal instillation of the live and virulent strain H-37Rv. The histopathological study clearly showed two phases of the disease. The first one was an acute phase which was characterized by inflammatory infiltrate in the alveolar-capillary interstitium, blood vessel and bronchial wall with formation of granulomas. In this acute phase, which lasted from 1 to 28 days, a clear predominance of Th1 cells was observed, manifested by a high percentage of interleukin-2 (IL-2) positive cells in the inflammatory infiltrate granulomas demonstrated by immunohistology, as well as a gradual increment of interferon-gamma (INF-gamma)m-RNA. This was followed by a chronic or advanced phase characterized by pneumonia, focal necrosis and fibrosis, with a Th0 balance due to an equivalent proportion of IL-2. and IL-4 positive cells in the lung lesions, that coincided with the highest level of INF-gamma and IL-4 mRNA. The cytofluorometric analysis of bronchial lavage cells, showed a predominance of CD4 T cells during the acute phase and CD8 T lymphocytes in the chronic phase. gamma-delta T lymphocytes showed two peaks, at the beginning (3 days) and at the end (4 months) of the infection. These results suggest that T-lymphocyte subset kinetics and the pattern of cytokines produced in the lung during tuberculosis infection changed over time and correlate with the type and magnitude of tissue injury.es_ES
dc.subject.kwT-Celles_ES
dc.subject.kwRegulación hacia abajoes_ES
dc.subject.kwLinfocitos-Tes_ES
dc.subject.kwSubconjuntos funcionaleses_ES
dc.subject.kwRespuestas inmuneses_ES
dc.subject.kwInfecciónes_ES
dc.subject.kwPerfileses_ES
dc.subject.kwGammaes_ES
dc.subject.kwCitoquinases_ES
dc.subject.kwAntígenoses_ES
dc.subject.koT-Celles_ES
dc.subject.koDown-Regulationes_ES
dc.subject.koLymphocytes-Tes_ES
dc.subject.koFunctional subsetses_ES
dc.subject.koImmune-responseses_ES
dc.subject.koInfectiones_ES
dc.subject.koProfileses_ES
dc.subject.koGammaes_ES
dc.subject.koCytokineses_ES
dc.subject.koAntigenses_ES


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