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Chronic Stress Induces Structural Alterations in Splenic Lymphoid Tissue That Are Associated with Changes in Corticosterone Levels in Wistar-Kyoto Rats

dc.creatorHernández, María Eugenia
dc.creatorMartínez-Mota, Lucía
dc.creatorSalinas, Citlaltepetl
dc.creatorMárquez-Velasco, Ricardo
dc.creatorHernández-Chan, Nancy G.
dc.creatorMorales-Montor, Jorge
dc.creatorPérez-Tapia, Mayra
dc.creatorStreber, María L.
dc.creatorGranados-Camacho, Ivonne
dc.creatorBecerril, Enrique
dc.creatorBaquera-Heredia, Javier
dc.creatorPavón, Lenin
dc.date.accessioned2017-06-30T03:42:58Z
dc.date.available2017-06-30T03:42:58Z
dc.date.issued2013es_ES
dc.identifier2162es_ES
dc.identifier.issn2314-6133es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/6812
dc.identifier.urihttps://doi.org/10.1155/2013/868742es_ES
dc.language.isoenges_ES
dc.publisherHINDAWI PUBLISHING CORPORATION, 410 PARK AVENUE, 15TH FLOOR, #287 PMB, NEW YORK, NY 10022 USAes_ES
dc.relation2013, 1-7 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.titleChronic Stress Induces Structural Alterations in Splenic Lymphoid Tissue That Are Associated with Changes in Corticosterone Levels in Wistar-Kyoto Ratses_ES
dc.typearticlees_ES
dc.contributor.affiliationInstituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, Direcc Invest Neurociencias, Lab Psicoinmunol, Tlalpan 14370, DF, Mexico.es_ES
dc.contributor.emaillkuriaki@imp.edu.mxes_ES
dc.relation.jnabreviadoBIOMED RES INTes_ES
dc.relation.journalBioMed research internationales_ES
dc.identifier.placeNew York, NYes_ES
dc.date.published2013es_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, México.es_ES
dc.identifier.eissn2314-6141es_ES
dc.identifier.doi10.1155/2013/868742   es_ES
dc.description.monthEnees_ES
dc.description.abstractotrodiomaMajor depressive disorder patients present chronic stress and decreased immunity. The Wistar-Kyoto rat (WKY) is a strain in which the hypothalamic-pituitary-adrenal axis is overactivated. To determine whether chronic stress induces changes in corticosterone levels and splenic lymphoid tissue, 9-week-old male rats were subject to restraint stress (3 h daily), chemical stress (hydrocortisone treatment, 50 mg/Kg weight), mixed stress (restraint plus hydrocortisone), or control treatment (without stress) for 1, 4, and 7 weeks. The serum corticosterone levels by RIA and spleens morphology were analyzed. Corticosterone levels as did the structure, size of the follicles and morphology of the parenchyma (increase in red pulp) in the spleen, varied depending on time and type of stressor. These changes indicate that chronic stress alters the immune response in the spleen in WKY rats by inducing morphological changes, explaining in part the impaired immunity that develops in organisms that are exposed to chronic stress.es_ES
dc.subject.kwTrastorno depresivo mayores_ES
dc.subject.kwCambios morfológicoses_ES
dc.subject.kwÓrganos endocrinoses_ES
dc.subject.kwAnálogo de la hormonaes_ES
dc.subject.kwPeso corporales_ES
dc.subject.kwIn-vitroes_ES
dc.subject.kwHPA-AXISes_ES
dc.subject.kwInmunees_ES
dc.subject.kwRatases_ES
dc.subject.kwGlucocorticoideses_ES
dc.subject.koMajor depressive disorderes_ES
dc.subject.koMorphological-changeses_ES
dc.subject.koEndocrine organses_ES
dc.subject.koHormone analoges_ES
dc.subject.koBody-weightes_ES
dc.subject.koIn-vitroes_ES
dc.subject.koHPA-AXISes_ES
dc.subject.koImmunees_ES
dc.subject.koMicees_ES
dc.subject.koGlucocorticoidses_ES


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