Mostrar el registro sencillo del ítem

Pathogenesis of tuberculosis in mice exposed to low and high doses of an environmental mycobacterial saprophyte before infection

dc.creatorHernández Pando, R.
dc.creatorPavón, L.
dc.creatorArriaga, K.
dc.creatorOrozco, H.
dc.creatorMadrid Marina, V.
dc.creatorRook, G.
dc.date.accessioned2017-06-30T03:42:55Z
dc.date.available2017-06-30T03:42:55Z
dc.date.issued1997es_ES
dc.identifier2161es_ES
dc.identifier.issn0019-9567es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/6811
dc.identifier.urihttps://doi.org/10.1128/iai.65.8.3317-3327.1997es_ES
dc.identifier.urihttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC175470/es_ES
dc.language.isoenges_ES
dc.publisherAMER SOC MICROBIOLOGY, 1752 N ST NW, WASHINGTON, DC 20036-2904 USAes_ES
dc.relation65 (8) 3317-3327 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.titlePathogenesis of tuberculosis in mice exposed to low and high doses of an environmental mycobacterial saprophyte before infectiones_ES
dc.typearticlees_ES
dc.contributor.affiliationUCL, SCH MED, DEPT BACTERIOL, LONDON W1P 6DB, ENGLANDes_ES
dc.contributor.emailg.rook@ucl.ac.uk.es_ES
dc.relation.jnabreviadoINFECT IMMUNes_ES
dc.relation.journalInfection and immunityes_ES
dc.identifier.placeWASHINGTON, DCes_ES
dc.date.published1997es_ES
dc.identifier.organizacionInstituto Mexicano de Psiquiatríaes_ES
dc.identifier.eissn1098-5522es_ES
dc.description.monthAgoes_ES
dc.description.abstractotrodiomaMycobacteria are ubiquitous in the environment, but they are not part of the normal human microbial flora, It has been suggested that variable contact with mycobacteria can influence susceptibility to mycobacterial pathogens and the efficacy of subsequent Mycobacterium bovis BCG vaccination, To test this, mice were immunized,vith high or low doses of an environmental saprophyte, M. vaccae, that is intensely immunogenic as an autoclaved preparation, Two months later, they received an intratracheal challenge with M, tuberculosis H37Rv, Recipients of a low Th1-inducing dose (10(7) organisms) were partially protected and maintained a high ratio of interleukin 2 (IL-2)-positive to IL-4-positive cells in the perivascular, peribronchial, and granulomatous areas of the lung, whereas in unimmunized controls the IL-4-positive cells increased markedly between days 21 and 28, In contrast, recipients of the high dose (10(9) organisms), which primes Th2 as well as Th1 cytokine production, died more rapidly than unimmunized controls and showed massive pneumonia from day 7, The ratio of IL-2-positive to IL-4-positive cells in all compartments of the lung rapidly fell to 1 by day 14 for these animals, These events correlated with cytokine mRNA profiles and with increases in the local toxicity of tumor necrosis factor alpha (TNF-alpha), demonstrable only when a major Th2 component was present, These data indicate that cross-reactive epitopes present in an environmental saprophyte can evoke either protective responses or responses that increase susceptibility to M, tuberculosis. The latter are associated with the presence of a Th2 component and increased sensitivity to TNF-alpha.es_ES
dc.subject.koTUMOR-NECROSIS-FACTORes_ES
dc.subject.koFACTOR-ALPHAes_ES
dc.subject.koT-CELLSes_ES
dc.subject.koPROTECTIVE EFFICACYes_ES
dc.subject.koIMMUNE-RESPONSEes_ES
dc.subject.koCALMETTE-GUERINes_ES
dc.subject.koTNF-ALPHAes_ES
dc.subject.koLEPROSYes_ES
dc.subject.koBCGes_ES
dc.subject.koRESPONSIVENESSes_ES


Ficheros en el ítem

FicherosTamañoFormatoVer

No hay ficheros asociados a este ítem.

Este ítem aparece en la(s) siguiente(s) colección(ones)

Mostrar el registro sencillo del ítem