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Frontal and limbic metabolic differences in subjects selected according to genetic variation of the SLC6A4 gene polymorphism

dc.creatorGraff-Guerrero, A.
dc.creatorDe la Fuente-Sandoval, C.
dc.creatorCamarena, B.
dc.creatorGómez-Martín, D.
dc.creatorApiquián, R.
dc.creatorFresán, A.
dc.creatorAguilar, A.
dc.creatorMéndez-Nuñez, J.C.
dc.creatorEscalona-Huerta, C.
dc.creatorDrucker-Colín, R.
dc.creatorNicolini, H.
dc.date.accessioned2017-06-30T03:42:53Z
dc.date.available2017-06-30T03:42:53Z
dc.date.issued2005es_ES
dc.identifier2160es_ES
dc.identifier.issn1053-8119es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/6810
dc.identifier.urihttps://doi.org/10.1016/j.neuroimage.2004.12.020es_ES
dc.language.isoenges_ES
dc.relation25, 1197-1204 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.titleFrontal and limbic metabolic differences in subjects selected according to genetic variation of the SLC6A4 gene polymorphismes_ES
dc.typearticlees_ES
dc.contributor.affiliationLaboratorio de Neurofisiolog?a Integrativa, Instituto Nacional de Psiquiatr?a Ramon de la Fuente, Mexico City, Mexicoes_ES
dc.contributor.emailariel.graff@camhpet.caes_ES
dc.relation.jnabreviadoNEUROIMAGEes_ES
dc.relation.journalNeuroimagees_ES
dc.identifier.placeOrlandoes_ES
dc.date.published2005es_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, México.es_ES
dc.identifier.eissn1095-9572es_ES
dc.identifier.doi10.1016/j.neuroimage.2004.12.020es_ES
dc.description.abstractotrodiomaAllelic variants in the promoter region of the serotonin transporter (5-HTT) gene have been implicated in several psychiatric disorders and personality traits. In particular, two common alleles in a variable repeat sequence of the promoter region (SLC6A4) have been differentially associated with a display of abnormal levels of anxiety and affective illness in individuals carrying the “s” allele. The aim of this study was to compare the basal cerebral metabolic activity of non-psychiatric subjects in fronto–limbic structures to determine whether differences exist in basal metabolic activity within this functional polymorphism. PET scans with fluorine-18 fluorodeoxyglucose as radiotracer were performed in 71 non-psychiatric subjects previously screened for psychopathology and subsequently genotyped for SLC6A4; PET images were compared with SPM2 according to s/s (n = 27), s/l (n = 25), and l/l (n = 19) groups considering a significance threshold in a priori selected areas of P < 0.001 and an extent threshold ?5 voxels. The analysis showed an effect of interest among the three genotype groups in right anterior cingulate gyrus (ACC), left middle frontal gyrus, and left posterior cingulate gyrus (PCC). Comparison between l/l vs. s/s showed increased metabolism for l/l in left middle frontal gyrus and an increase for s/s in right ACC and left PCC. Comparison between s/s vs. s/l showed an increase for s/s in left PCC and right ACC. Increased basal metabolism in fronto–limbic structures for the s/s group may be conceived as an “overactive metabolic state” of these structures, possibly related to an increased susceptibility for developing an anxiety–depression spectrum disorder.es_ES
dc.subject.kwSLC6A4es_ES
dc.subject.kw5-HTTes_ES
dc.subject.kwPolimorfismoes_ES
dc.subject.kwTomografía por emisión de positroneses_ES
dc.subject.kwMetabolismo cerebrales_ES
dc.subject.koSLC6A4es_ES
dc.subject.ko5-HTTes_ES
dc.subject.koPolymorphismes_ES
dc.subject.koPositron emission tomographyes_ES
dc.subject.koCerebral metabolismes_ES


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