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Alterations on the morphology, nitric oxide synthesis and activity of platelets reproduced in rats as possible biomarkers for depression are reversed by fluoxetine

dc.creatorGonzález-Trujano, María Eva
dc.creatorAlvarado-Vásquez, Noé
dc.creatorMendoza-Sotelo, José
dc.creatorLópez, Guadalupe
dc.creatorEstrada-Camarena, Erika
dc.creatorMartínez-Mota, Lucía
dc.creatorMoreno, Julia
dc.date.accessioned2017-06-30T03:42:51Z
dc.date.available2017-06-30T03:42:51Z
dc.date.issued2012es_ES
dc.identifier2159es_ES
dc.identifier.issn0091-3057es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/6809
dc.identifier.urihttps://doi.org/10.1016/j.pbb.2012.03.012es_ES
dc.language.isoenges_ES
dc.publisherELSEVIER SCIENCE INC, 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USAes_ES
dc.relation102 (2) 349-356 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.titleAlterations on the morphology, nitric oxide synthesis and activity of platelets reproduced in rats as possible biomarkers for depression are reversed by fluoxetinees_ES
dc.typearticlees_ES
dc.contributor.affiliationInstituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, Calz, México-Xochimilco 101, Col. Sn Lorenzo Huipulco 14370, México, D.F., Mexicoes_ES
dc.contributor.emailmoreno@imp.edu.mxes_ES
dc.relation.jnabreviadoPHARMACOL BIOCHEM BEHAVes_ES
dc.relation.journalPharmacology, biochemistry, and behaviores_ES
dc.identifier.placeTarrytown, NYes_ES
dc.date.published2012es_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, México.es_ES
dc.identifier.eissn1873-5177es_ES
dc.identifier.doi10.1016/j.pbb.2012.03.012es_ES
dc.description.monthMares_ES
dc.description.abstractotrodiomaBiochemical markers associated with the prognosis of depression in humans are being described in the literature, whereas experimental studies in animal models in search for antidepressant strategies are lacking. The aim of this study was to evaluate platelet morphology, platelet activity and nitric oxide (NO) synthesis as possible biomarkers of depressive-like behavior by using FST alone and in the presence of fluoxetine. Naïve rats were compared to those receiving vehicle or fluoxetine at 10 mg/kg i.p. in acute, subchronic and chronic administration in the FST. After behavioral assessment, platelets were isolated from blood samples and analyzed by flow cytometry to determine the platelet mitochondrial membrane potential and NO synthesis. In addition, HPLC and electron microscopy were used to examine 5-HT and tryptophan levels and morphology of platelets, respectively. Rats receiving vehicle and exposed to FST showed depressive-like behavior at all the times tested; after chronic FST rats showed a similar pattern of alteration in platelet morphology and in the studied as possible biochemical markers as those previously recognized in depressive humans. Depressive-like behavior in rats exposed to FST was prevented in the presence of fluoxetine administration at all the times tested and associated with the prevention of alterations in platelet morphology, platelet activity and NO synthesis, and/or in 5-HT concentrations. The results of the present study suggest that platelet function and morphology might be relevant markers for the prognosis of depression and the search for functional treatments. Besides, the relevance of FST as model to study this psychiatric illness is reinforced.es_ES
dc.subject.meshmAnimalses_ES
dc.subject.meshmBehavior, Animal-Drug effectses_ES
dc.subject.meshmBiological Markers-Bloodes_ES
dc.subject.meshmBlood Platelets-Drug effectses_ES
dc.subject.meshmBlood Platelets-Metabolismes_ES
dc.subject.meshmBlood Platelets-Ultrastructurees_ES
dc.subject.meshmDepression-Bloodes_ES
dc.subject.meshmDepression-Drug therapyes_ES
dc.subject.meshmFluoxetine-Pharmacologyes_ES
dc.subject.meshmFluoxetine-Therapeutic usees_ES
dc.subject.meshmMalees_ES
dc.subject.meshmMembrane Potentialses_ES
dc.subject.meshmNitric Oxide-Biosynthesises_ES
dc.subject.meshmRatses_ES
dc.subject.meshmRats, Wistares_ES
dc.subject.meshmSerotonin-Bloodes_ES
dc.subject.meshmSerotonin Uptake Inhibitors-Pharmacologyes_ES
dc.subject.meshmSerotonin Uptake Inhibitors-Therapeutic usees_ES
dc.subject.meshmTryptophan-Bloodes_ES
dc.subject.kwDepresiónes_ES
dc.subject.kwFluoxetinaes_ES
dc.subject.kwPrueba forzada de nataciónes_ES
dc.subject.kwMorfologíaes_ES
dc.subject.kwOxido nítricoes_ES
dc.subject.kwPlaquetases_ES
dc.subject.kwSerotoninaes_ES
dc.subject.koDepressiones_ES
dc.subject.koFluoxetinees_ES
dc.subject.koForced swimming testes_ES
dc.subject.koMorphologyes_ES
dc.subject.koNitric oxidees_ES
dc.subject.koPlateletses_ES
dc.subject.koSerotonines_ES


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