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Pro-sexual effects of Turnera diffusa Wild (Turneraceae) in male rats involves the nitric oxide pathway

dc.creatorEstrada Reyes, R.
dc.creatorCarro Juárez, M.
dc.creatorMartínez Mota, L.
dc.date.accessioned2017-06-30T03:42:40Z
dc.date.available2017-06-30T03:42:40Z
dc.date.issued2013es_ES
dc.identifier2152es_ES
dc.identifier.issn0378-8741es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/6804
dc.identifier.urihttps://doi.org/10.1016/j.jep.2012.12.025es_ES
dc.language.isoenges_ES
dc.publisherELSEVIER IRELAND LTD, ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELANDes_ES
dc.relation146 (1) 164-172 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.titlePro-sexual effects of Turnera diffusa Wild (Turneraceae) in male rats involves the nitric oxide pathwayes_ES
dc.typearticlees_ES
dc.contributor.affiliationLaboratorio de Fitofarmacología, Dirección de Investigaciones en Neurociencias, Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, Calzada México-Xochimilco 101, Col. San Lorenzo Huipulco, Delegación Tlalpan, Mexico City 14370, Méxicoes_ES
dc.contributor.emaillucy_mota322@yahoo.com.mxes_ES
dc.relation.jnabreviadoJ ETHNOPHARMACOLes_ES
dc.relation.journalJournal of Ethnopharmacologyes_ES
dc.identifier.placeClare, Irelandes_ES
dc.date.published2013es_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, México.es_ES
dc.identifier.eissn1872-7573es_ES
dc.identifier.doidx.doi.org/10.1016/j.jep.2012.12.025es_ES
dc.description.monthEnees_ES
dc.description.abstractotrodiomaEthnopharmacologicalrelevance:Turneradiffusa Wild hasbeenusedinfolkmedicinebyitsaphrodisiac and ranquilizingproperties.Previouslyweexperimentallyshowedtheaphrodisiaceffectofa chemicallycharacterizedaqueousextractof Turnera diffusa in malerats.However,themechanismof action underlyingsucheffectshasnotbeenstudied. Study aims: As artofoursystematicstudiesofpharmacologicalpropertiesof Turneradiffusa, weaimed to analyzewhethertheincreasedsexualmotivationandtheaugmentedsexualperformanceofsexually sluggish (SL)maleratstreatedwith Turnera diffusa involvestheNOpathway.Additionallyweanalyzed whethersucheffectswereexertedatthelevelofthebrainorthespinalcord.Finally,anxietylevelsand ambulatoryactivitywerealsoevaluated. Material andmethods:Turneradiffusa (10–40 mg/kg)andsildenafilcitrate(10mg/kg)withorwithouta nonspecificinhibitorofNOsynthase,No-nitro-L-argininemethylesther(L-NAME, 12.5mg/kg)were evaluatedinSLrats,inastandardsexualbehaviortestandinthefictiveejaculationmodelinspinal cord transectedandurethane-anaesthetizedSLrats.Anxietylevelsorambulationwereassessedinthe buryingbehaviorandopen-fieldtests. Results:Turneradiffusa and sildenafil(bothat10mg/kg)facilitatedexpressionofmalesexualbehavior by shorteningmainlyejaculationlatency.Treatmentsalsofacilitatedthenumberofdischargesinthe ejaculatorymotorpatternaswellasthenumberofejaculatorymotorpatternsanditsassociatedpenile erections. L-NAMEpreventedthepro-sexualeffectsoftreatmentsonbothexperimentalmodels. Besides,theextractof Turneradiffusa (10 mg/kg)producedananxiolytic-likeeffectinmalerats withoutaffectingambulation. Conclusions: Findingsfromthepresentworksupportthenotionthatpro-sexualeffectoftheaqueous extractof Turnera diffusa in ratsinvolvestheparticipationofNOpathway,mainlyatcentrallevel.The anxiolytic-likeeffectof Turneradiffusa is anadvantagetoitsuseforimprovingsexualperformance.es_ES
dc.subject.kwComportamiento sexual de la rata machoes_ES
dc.subject.kwVía del óxido nítricoes_ES
dc.subject.kwAnsiedades_ES
dc.subject.kwTurnera diffusaes_ES
dc.subject.kwModelo de la eyaculación fictivees_ES
dc.subject.koMale rat sexual behaviores_ES
dc.subject.koNitric oxide pathwayes_ES
dc.subject.koTurnera diffusaes_ES
dc.subject.koAnxietyes_ES
dc.subject.koFictive ejaculation modeles_ES


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