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Desipramine restricts estral cycle oscillations in swimming

dc.creatorContreras, Carlos M.
dc.creatorMartínez-Mota, Lucía
dc.creatorSaavedra, Margarita
dc.date.accessioned2017-06-30T03:42:35Z
dc.date.available2017-06-30T03:42:35Z
dc.date.issued1998es_ES
dc.identifier2147es_ES
dc.identifier.issn0278-5846es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/6802
dc.identifier.urihttps://doi.org/10.1016/S0278-5846(98)00066-9es_ES
dc.language.isoenges_ES
dc.publisherPERGAMON-ELSEVIER SCIENCE LTD, THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLANDes_ES
dc.relation22, 1121-1128 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.titleDesipramine restricts estral cycle oscillations in swimminges_ES
dc.typearticlees_ES
dc.contributor.affiliationLaboratorio de Neurofarmacología, Instituto de Neuroetología, Universidad Veracruzana Méxicoes_ES
dc.contributor.emailcmc@bugs.invest.uv.mxes_ES
dc.relation.jnabreviadoPROG NEUROPSYCHOPHARMACOL BIOL PSYCHIATRYes_ES
dc.relation.journalProgress in neuro-psychopharmacology & biological psychiatryes_ES
dc.identifier.placeOxfordes_ES
dc.date.published1998es_ES
dc.identifier.organizacionInstituto Mexicano de Psiquiatríaes_ES
dc.identifier.eissn1878-4216es_ES
dc.description.monthAgoes_ES
dc.description.abstractotrodioma1. Desipramine (DMI) is a tricyclic antidepressant which reduces the immobility in rats forced to swim; however, it is unknown whether estral cycle phases impinge on DMI actions on rmmobility in daily swimming tests during several weeks. 2. In female wistar rats, vaginal smears taken before testing defined four estral phases. Afterwards, the authors assessed the latency for the first period of immobility in five-min forced swim tests practiced on 21-day DMI (DMI group), 21day washout saline given after a 21-day DMI treatment (washout-saline group), or non-treated rats (control group). 3. We observed a longer latency for the first period of immobility in proestrus-estrus from the control and washout-saline groups. The 21day treatment with DMI (2.1 mg/kg i.p., once a day) significantly (p < 0.001) increased the latency by about 160% from control regardless of the estral cycle phase. 4. It is concluded that proestrus-estrus relates to increased struggling behavior. DMI enhances struggling behavior independently of hormonal state.es_ES
dc.subject.kwDepresión-Modulaciónes_ES
dc.subject.kwCiclo estrales_ES
dc.subject.koAntidepressantses_ES
dc.subject.koDepression-Modulationes_ES
dc.subject.koDesipraminees_ES
dc.subject.koEstral cyclees_ES
dc.subject.koForced-swimes_ES


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