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Crude preparations of Dioon spinulosum dyer neurotoxicity: methylazoxymethanol produces petil mal seizures in susceptible individuals

dc.creatorContreras, C.M.
dc.creatorSaavedra, M.V.
dc.creatorMartínez-Mota, L.
dc.creatorOrtíz, M.
dc.creatorVázquez-Torres, M.
dc.date.accessioned2017-06-30T03:42:34Z
dc.date.available2017-06-30T03:42:34Z
dc.date.issued1998es_ES
dc.identifier2146es_ES
dc.identifier.issn0944-7113es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/6801
dc.identifier.urihttps://doi.org/10.1016/S0944-7113(98)80033-0es_ES
dc.language.isoenges_ES
dc.relation5 (2) 227-233 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.titleCrude preparations of Dioon spinulosum dyer neurotoxicity: methylazoxymethanol produces petil mal seizures in susceptible individualses_ES
dc.typearticlees_ES
dc.contributor.affiliationLaboratorio de Neurofarmacología, Instituto de Neuroetología, Universidad Veracruzana Instituto de Investigaciones Biomédicas, UNAMes_ES
dc.contributor.emailcmc@bugs.invest.uv.mxes_ES
dc.relation.jnabreviadoPHYTOMEDICINEes_ES
dc.relation.journalPhytomedicine : international journal of phytotherapy and phytopharmacologyes_ES
dc.identifier.placeStuttgart : Urban & Fischer Verlages_ES
dc.date.published1998es_ES
dc.identifier.organizacionInstituto de Investigaciones Biomedicas, UNAMes_ES
dc.identifier.eissn1618-095Xes_ES
dc.description.abstractotrodiomaDioon spinulosum is a cycad prepared as an alternative food and consumed by Chinantecos from Veracruz and Oaxaca, México. Whether Dioon spinulosum possesses neurotoxic properties is unknown, therefore, we used wistar rats receiving several regimens of D. spinulosum. Semi-liquid diarrhea followed the ingestion of crude kernels of D. spinulosum (group-1). In group-2 we offered during 10 days, purine and water during 12 h/day, and kernel or sclerotesta during the remaining 12 h (8.00 p.m. to 8.00 a.m.). As a result, a significantly decreased ingestion of water and cycad was compensated by a higher ingestion of purine and water during the period for which they had access to their normal diet. In group-3 which received lyophilized powdered crude kernel through a displaceable oesophagic cannula during 80 days, the locomotor activity was significantly lowered (p<0.05), but their fine motor ability for swimming remained unaltered. In this group, the computerized analysis of the electroencephalogram illustrated a dominance of high-voltage, high-frequency waves as compared to a matched-age control group (p<0.05). In group-4, the active toxin of cycads, methylazoxymethanol-glucoside applied directly to the cerebral cortex (1 ?l), produced an epileptic status (spike-wave activity: 3–6 Hz/200 ?V) lasting more than six hours in 30% of the animals. In conclusion, D. spinulosum produced a decrease in gross locomotor activity, and an increased excitability of the central nervous system.es_ES
dc.subject.kwAusenciaes_ES
dc.subject.kwCícadases_ES
dc.subject.kwEpilepsiaes_ES
dc.subject.kwLocomotores_ES
dc.subject.kwMetilazoximetanoles_ES
dc.subject.kwPetit males_ES
dc.subject.kwPunta-ondaes_ES
dc.subject.kwNataciónes_ES
dc.subject.koAbsencees_ES
dc.subject.koCycadses_ES
dc.subject.koEpilepsyes_ES
dc.subject.koLocomotores_ES
dc.subject.koMethylazoxymethanoles_ES
dc.subject.koPetit males_ES
dc.subject.koSpike-wavees_ES
dc.subject.koSwimminges_ES


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