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A non-invasive method to isolate the neuronal linage from the nasal epithelium from schizophrenic and bipolar diseases

dc.creatorBenítez-King, G.
dc.creatorRiquelme, A.
dc.creatorOrtíz-López, L.
dc.creatorBerlanga, C.
dc.creatorRodríguez-Verdugo, M.S.
dc.creatorRomo, F.
dc.creatorCalixto, E.
dc.creatorSolís-Chagoyán, H.
dc.creatorJiménez, M.
dc.creatorMontaño, L.M.
dc.creatorRamírez-Rodríguez, G.
dc.creatorMorales-Mulia, S.
dc.creatorDomínguez-Alonso, A.
dc.date.accessioned2017-06-30T03:42:26Z
dc.date.available2017-06-30T03:42:26Z
dc.date.issued2011es_ES
dc.identifier2142es_ES
dc.identifier.issn0165-0270es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/6797
dc.identifier.urihttps://doi.org/10.1016/j.jneumeth.2011.07.009es_ES
dc.language.isoenges_ES
dc.publisherSPRINGER, VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDSes_ES
dc.relation201, 35-45 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.titleA non-invasive method to isolate the neuronal linage from the nasal epithelium from schizophrenic and bipolar diseaseses_ES
dc.typearticlees_ES
dc.contributor.affiliationDepartamento de Neurofarmacología, Instituto Nacional de Psiquiatría Ramón de la Fuente Mu˜niz, Mexico City, Mexicoes_ES
dc.contributor.emailbekin@imp.edu.mxes_ES
dc.relation.jnabreviadoJ NEUROSCI METHODSes_ES
dc.relation.journalJournal of neuroscience methodses_ES
dc.identifier.placeNetherlandses_ES
dc.date.published2011es_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñizes_ES
dc.identifier.eissn1872-678Xes_ES
dc.identifier.doi10.1016/j.jneumeth.2011.07.009es_ES
dc.description.monthJules_ES
dc.description.abstractotrodiomaBrain imaging and histopathological studies suggest that neurodevelopmental anomalies play a key role in the etiology of schizophrenia (SZ) and bipolar disorder (BD). New neuron formation and maturation occur in human olfactory epithelium throughout life. Therefore, the olfactory epithelium has been proposed as a model to study alterations in neurodevelopment, particularly in some psychiatric diseases. However, former studies were done with olfactory epithelium biopsies taken post mortem or under anesthesia from patients with SZ and BD. In this work we have developed a new method to obtain viable neural precursors by exfoliation of the anterior region of the medial lateral turbinate of the nasal cavity from healthy controls, and ambulatory patients. Cells were propagated to establish neural precursor banks. Thawed cells showed cytoskeletal phenotypes typical of developing neurons. They also conserved the ability to differentiate in presence of 2 mM dibutyril-cyclic adenosine monophosphate, and maintained voltage-operated Ca2+ currents in culture. Moreover, proportions of neuronal maturation stages were maintained in cultured exfoliates obtained from SZ and BD patients. Data support that neural precursors obtained from a nasal exfoliate are an excellent experimental model to later approach studies on biomarkers, neural development and cellular alterations in the pathophysiology of SZ and BD.es_ES
dc.subject.koNasal epitheliumes_ES
dc.subject.koNeural precursorses_ES
dc.subject.koCytoskeletones_ES
dc.subject.koSchizophreniaes_ES
dc.subject.koBipolar disorderes_ES
dc.subject.koNeurodevelopmentes_ES


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