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Peripheral involvement of the nitric oxide-cGMP pathway in the indomethacin-induced antinociception in rat

dc.creatorVentura-Martínez, Rosa
dc.creatorDéciga-Campos, Myrna
dc.creatorDíaz-Reval, Ma. Irene
dc.creatorGonzález-Trujano, Ma. Eva
dc.creatorLópez-Muñoz, Francisco J.
dc.date.accessioned2017-06-30T03:42:19Z
dc.date.available2017-06-30T03:42:19Z
dc.date.issued2004es_ES
dc.identifier2137es_ES
dc.identifier.issn0014-2999es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/6793
dc.identifier.urihttps://doi.org/10.1016/j.ejphar.2004.09.018es_ES
dc.language.isoenges_ES
dc.publisherElsevier B.V.es_ES
dc.relation503 (1-3) 43-48 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.titlePeripheral involvement of the nitric oxide-cGMP pathway in the indomethacin-induced antinociception in rates_ES
dc.typearticlees_ES
dc.contributor.affiliationFacultad de Medicina, Departamento de Farmacología, Universidad Nacional Autónoma de México, Ciudad Universitaria Coyoacán, C.P. 04510, México, D.F., Méxicoes_ES
dc.contributor.emailflopezm@prodigy.net.mxes_ES
dc.relation.jnabreviadoEUR J PHARMACOLes_ES
dc.relation.journalEuropean journal of pharmacologyes_ES
dc.identifier.placeHolandaes_ES
dc.date.published2004es_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñizes_ES
dc.identifier.eissn1879-0712es_ES
dc.identifier.doi10.1016/j.ejphar.2004.09.018es_ES
dc.description.monthOctes_ES
dc.description.abstractotrodiomaThe role of nitric oxide (NO) in the antinociceptive effect of indomethacin was assessed in the pain-induced functional impairment model in the rat (PIFIR model), a model of inflammatory and chronic pain similar to that observed in clinical gout. Oral administration of indomethacin (5.6 mg/kg), a nonselective cyclooxygenase inhibitor, significantly decreased the nociceptive response elicited by uric acid injected into the knee joint of the right hind limb (2.0+/-3.0 and 149.7+/-18.0 area units [au], in the absence and the presence of indomethacin, respectively). This effect of indomethacin was reduced in nearly 50% by local pretreatment with the nonselective inhibitor of NO synthase, N G-L-nitro-arginine methyl ester (L-NAME) (72.9+/-10.7 vs. 149.7+/-18.0 au, P<0.05). On the other hand, local administration of L-arginine (a NO synthase substrate) or sodium nitroprusside (a non-enzymatic NO donor) each increased in almost 40% the antinociceptive effect of indomethacin (230.9+/-12.6 and 226.6+/-9.7 vs. 149.7+/-18.0 au, P<0.05), whereas D-arginine (the inactive isomer of arginine) had no effect on the indomethacin antinociceptive response (208.0+/-34.9 vs. 149.7+/-18.0 au). These results suggest that, the antinociceptive effect of indomethacin involves, at least in part, the NO-cyclic GMP pathway at peripheral level.es_ES
dc.subject.meshmAnimalses_ES
dc.subject.meshmAnti-Inflammatory Agents, Non-Steroidal-Pharmacologyes_ES
dc.subject.meshmArginine-Metabolismes_ES
dc.subject.meshmChronic Diseasees_ES
dc.subject.meshmCyclic GMP-Physiologyes_ES
dc.subject.meshmDisease Models, Animales_ES
dc.subject.meshmEnzyme Inhibitors-Pharmacologyes_ES
dc.subject.meshmFemalees_ES
dc.subject.meshmGout-Chemically inducedes_ES
dc.subject.meshmGout-Complicationses_ES
dc.subject.meshmGout-Psychologyes_ES
dc.subject.meshmIndomethacin-Pharmacologyes_ES
dc.subject.meshmNG-Nitroarginine Methyles_ES
dc.subject.meshmEster-Pharmacologyes_ES
dc.subject.meshmNerve Tissue Proteins-Antagonists & inhibitorses_ES
dc.subject.meshmNitric Oxide-Physiologyes_ES
dc.subject.meshmNitric Oxide Donors-Pharmacologyes_ES
dc.subject.meshmNitric Oxide Synthase-Antagonists & inhibitorses_ES
dc.subject.meshmNitric Oxide Synthase Type Ies_ES
dc.subject.meshmNitroprusside-Pharmacologyes_ES
dc.subject.meshmPain-Chemically inducedes_ES
dc.subject.meshmPain-Drug therapyes_ES
dc.subject.meshmPain Measurement-Drug effectses_ES
dc.subject.meshmPeripheral Nervouses_ES
dc.subject.meshmSystem-Drug effectses_ES
dc.subject.meshmRatses_ES
dc.subject.meshmRats, Wistares_ES
dc.subject.meshmSignal Transduction-Physiologyes_ES
dc.subject.meshmUric Acides_ES
dc.subject.kwModelo PIFIRes_ES
dc.subject.kwIndometacinaes_ES
dc.subject.kwAntinocicepciónes_ES
dc.subject.kwÓxido nítricoes_ES
dc.subject.kwRataes_ES
dc.subject.koPIFIR modeles_ES
dc.subject.koIndomethacines_ES
dc.subject.koAntinociceptiones_ES
dc.subject.koNitric oxidees_ES
dc.subject.koRates_ES


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