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Importance of Melanocortin Signaling in Refeeding- Induced Neuronal Activation and Satiety

dc.creatorSingru, Praful S.
dc.creatorSánchez, Edith
dc.creatorFekete, Csaba
dc.creatorLechan, Ronald M.
dc.date.accessioned2017-06-30T03:42:11Z
dc.date.available2017-06-30T03:42:11Z
dc.date.issued2007es_ES
dc.identifier2131es_ES
dc.identifier.issn0013-7227es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/6789
dc.identifier.urihttps://doi.org/10.1210/en.2006-1233es_ES
dc.language.isoenges_ES
dc.publisherThe Endocrine Societyes_ES
dc.relation148 (2) 638-646 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.titleImportance of Melanocortin Signaling in Refeeding- Induced Neuronal Activation and Satietyes_ES
dc.typearticlees_ES
dc.contributor.affiliationTupper Research Institute and Department of Medicine (P.S.S., E.S., C.F., R.M.L.), Division of Endocrinology, Diabetes, and Metabolism, Tufts-New England Medical Center, Boston, Massachusetts 02111es_ES
dc.relation.jnabreviadoENDOCRINOLOGYes_ES
dc.relation.journalEndocrinologyes_ES
dc.identifier.placeEstados Unidoses_ES
dc.date.published2007es_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñizes_ES
dc.identifier.doi10.1210/en.2006-1233es_ES
dc.description.monthFebes_ES
dc.description.abstractotrodiomaTo identify regions in the hypothalamus involved in refeeding and their regulation by -MSH, adult rats were subjected to a 3-d fast, and 2 h after refeeding, the distribution of c-Fosimmunoreactive neurons was elucidated. Compared with fed and fasted animals, a significant increase (P < 0.001) in the number of c-Fos-immunoreactive cells was identified in refed animals in the supraoptic nucleus, magnocellular and ventral parvocellular subdivisions of the hypothalamic paraventricular nucleus (PVNv), and the dorsal and ventral subdivisions of the dorsomedial nucleus (DMNd and DMNv, respectively). Refeeding shifted the location of c-Fos-labeled neurons from the medial to lateral arcuate where c-Fos was induced in 88.7 2.2% of -MSH-containing neurons. -MSH-containing axons densely innervated the PVNv, DMNd, and DMNv and organized in close apposition to the majority of refeedingactivated c-Fos-positive neurons. To test whether the melanocortin system is involved in induction of c-Fos in these regions, the melanocortin 3/4 receptor antagonist, agouti-related protein (AGRP 83–132), was administered to fasting animals just before refeeding. Compared with artificial cerebrospinal fluid, a single intracerebroventricular bolus of agoutirelated protein (5 g/5 l) not only significantly increased the total amount of food consumed within 2 h but also nearly abolished refeeding-induced c-Fos expression in the PVNv and DMNd and partially reduced c-Fos immunoreactivity in the DMNv. We conclude that refeeding activates a subset of neurons in the PVN and DMN as a result of increased melanocortin signaling and propose that one or more of these neuronal populations mediate the potent anorexic actions of -MSH.es_ES


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