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Differential Effects of Refeeding on Melanocortin-Responsive Neurons in the Hypothalamic Paraventricular Nucleus

dc.creatorSánchez, Edith
dc.creatorSingru, Praful S.
dc.creatorAcharya, Runa
dc.creatorBodria, Monica
dc.creatorFekete, Csaba
dc.creatorZavacki, Ann Marie
dc.creatorBianco, Antonio C.
dc.creatorLechan, Ronald M.
dc.date.accessioned2017-06-30T03:42:07Z
dc.date.available2017-06-30T03:42:07Z
dc.date.issued2008es_ES
dc.identifier2128es_ES
dc.identifier.issn0013-7227es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/6786
dc.identifier.urihttps://doi.org/10.1210/en.2008-0411es_ES
dc.identifier.urihttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2553369/es_ES
dc.language.isoenges_ES
dc.publisherThe Endocrine Societyes_ES
dc.relation149 (9) 4329–4335 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.titleDifferential Effects of Refeeding on Melanocortin-Responsive Neurons in the Hypothalamic Paraventricular Nucleuses_ES
dc.typearticlees_ES
dc.contributor.affiliationTupper Research Institute and Department of Medicine, Division of Endocrinology, Diabetes, and Metabolism, Tufts Medical Center, Boston, Massachusetts 02111; Department of Endocrine Neurobiologyes_ES
dc.relation.jnabreviadoENDOCRINOLOGYes_ES
dc.relation.journalEndocrinologyes_ES
dc.identifier.placeEstados Unidoses_ES
dc.date.published2008es_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñizes_ES
dc.identifier.doi10.1210/en.2008-0411es_ES
dc.description.monthSepes_ES
dc.description.abstractotrodiomaTo explore the effect of refeeding on recovery of TRH gene expression in the hypothalamic paraventricular nucleus (PVN) and its correlation with the feeding-related neuropeptides in the arcuate nucleus (ARC), c-fos immunoreactivity (IR) in the PVN and ARC 2 h after refeeding and hypothalamic TRH, neuropeptide Y (NPY) and agouti-related protein (AGRP) mRNA levels 4, 12, and 24 h after refeeding were studied in Sprague-Dawley rats subjected to prolonged fasting. Despite rapid reactivation of proopiomelanocortin neurons by refeeding as demonstrated by c-fos IR in ARC -MSH-IR neurons and ventral parvocellular subdivision PVN neurons, c-fos IR was present in only 9.7 1.1% hypophysiotropic TRH neurons. Serum TSH levels remained suppressed 4 and 12 h after the start of refeeding, returning to fed levels after 24 h. Fasting reduced TRH mRNA compared with fed animals, and similar to TSH, remained suppressed at 4 and 12hafter refeeding, returning toward normal at 24 h. AGRP and NPY gene expression in the ARC were markedly elevated in fasting rats, AGRP mRNA returning to baseline levels 12 h after refeeding and NPY mRNA remaining persistently elevated even at 24 h. These data raise the possibility that refeeding-induced activation of melanocortin signaling exerts differential actions on its target neurons in the PVN, an early action directed at neurons that may be involved in satiety, and a later action on hypophysiotropic TRH neurons involved in energy expenditure, potentially mediated by sustained elevations in AGRP and NPY. This response may be an important homeostatic mechanism to allow replenishment of depleted energy stores associated with fastinges_ES


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