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Cocaine- and amphetamine-regulated transcript (CART) expression is differentially regulated in the hypothalamic paraventricular nucleus of lactating rats exposed to suckling or cold stimulation

dc.creatorSánchez, Edith
dc.creatorFekete, Csaba
dc.creatorLechan, Ronald M.
dc.creatorJoseph-Bravo, Patricia
dc.date.accessioned2017-06-30T03:42:05Z
dc.date.available2017-06-30T03:42:05Z
dc.date.issued2007es_ES
dc.identifier2127es_ES
dc.identifier.issn0006-8993es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/6785
dc.identifier.urihttps://doi.org/10.1016/j.brainres.2006.11.020es_ES
dc.identifier.urihttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1963438/es_ES
dc.language.isoenges_ES
dc.publisherElsevier B.V.es_ES
dc.relation1132, 120-128 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.titleCocaine- and amphetamine-regulated transcript (CART) expression is differentially regulated in the hypothalamic paraventricular nucleus of lactating rats exposed to suckling or cold stimulationes_ES
dc.typearticlees_ES
dc.contributor.affiliationDepartamento de Genética del Desarrollo y Fisiología Molecular, Instituto de Biotecnología, Universidad Nacional Autónoma de México, AP 510-3, Cuernavaca, Mor., C.P. 62210, Méxicoes_ES
dc.contributor.emailjoseph@ibt.unam.mxes_ES
dc.relation.jnabreviadoBRAIN RESes_ES
dc.relation.journalBrain Researches_ES
dc.date.published2007es_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñizes_ES
dc.identifier.doi:10.1016/j.brainres.2006.11.020es_ES
dc.description.monthFebes_ES
dc.description.abstractotrodiomaNeural stimuli, such as suckling or cold exposure, increase TRH mRNA in the paraventricular nucleus (PVN) of the rat hypothalamus, yet only suckling induces prolactin secretion. As TRH co-localizes with cocaine- and amphetamine-regulated transcript (CART) in hypophysiotropic neurons of the PVN, and CART inhibits TRHinduced prolactin release but not TRH-induced TSH release in adenohypophyseal cell cultures, we raised the possibility that differential regulation of CART gene expression in the PVN may explain the differences in prolactin secretion following each of the two stimuli. Primiparous female rats were mated and handled daily during the pre- and postpartum periods. After delivery, the litter was adjusted to 8 pups and at mid-lactation, dams were separated from their pups for 8 h and exposed to either 1 h of cold or 30 min of suckling. Long-term effects of suckling were studied by separating pups from their mothers for 24 h, followed by a 12 h period of continuous suckling. Serum TSH levels increased in response to cold exposure, while prolactin levels were increased by suckling and diminished by cold exposure. CART mRNA levels increased in rostral and mid parts of the medial parvocellular PVN following cold exposure but not after suckling stimulation. These data demonstrate a differential regulation of CART gene expression in hypophysiotropic neurons in response to stimuli that increase TRH mRNA levels, and suggest that CART activation in the PVN may contribute to the decrease in PRL release when the thyroid axis is activated by cold exposurees_ES
dc.subject.koCocaine- and amphetamine-regulated transcriptes_ES
dc.subject.koTRHes_ES
dc.subject.koSucklinges_ES
dc.subject.koColdes_ES
dc.subject.koProlactines_ES
dc.subject.koIn situ hybridizationes_ES
dc.subject.koHypothalamic paraventricular nucleuses_ES


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