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Characterization of benzodiazepine receptor binding in immature rat brain after kainic acid administration

dc.creatorRocha, Luisa
dc.creatorGonzález-Trujano, M.Eva
dc.creatorJiménez, Graciela
dc.creatorGaona, Andrés
dc.creatorOndarza, Rodolfo
dc.date.accessioned2017-06-30T03:41:56Z
dc.date.available2017-06-30T03:41:56Z
dc.date.issued2000es_ES
dc.identifier2120es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/6778
dc.identifier.urihttps://doi.org/10.1111/j.1528-1157.2000.tb01555.xes_ES
dc.language.isoenges_ES
dc.publisherLippincott Williams & Wilkins, Inc., Baltimore International League Against Epilepsyes_ES
dc.relation41 (Sup.6) S44-S47 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.subject.meshAge Factorses_ES
dc.subject.meshAnimalses_ES
dc.subject.meshAutoradiographyes_ES
dc.subject.meshBrain-Growth & developmentes_ES
dc.subject.meshBrain-Metabolismes_ES
dc.subject.meshCerebral Cortex-Drug effectses_ES
dc.subject.meshCerebral Cortex-Growth & developmentes_ES
dc.subject.meshCerebral Cortex-Metabolismes_ES
dc.subject.meshDisease Models, Animales_ES
dc.subject.meshEpilepsy, Temporal Lobe-Metabolismes_ES
dc.subject.meshFlunitrazepam-Diagnostic usees_ES
dc.subject.meshKainic Acid-Administration & dosagees_ES
dc.subject.meshKainic Acid-Pharmacologyes_ES
dc.subject.meshMalees_ES
dc.subject.meshRatses_ES
dc.subject.meshRats, Wistares_ES
dc.subject.meshReceptors, GABA-A-Drug effectses_ES
dc.subject.meshReceptors, GABA-A-Metabolismes_ES
dc.subject.meshStatus Epilepticus-Chemically inducedes_ES
dc.subject.meshStatus Epilepticus-Metabolismes_ES
dc.subject.meshTritiumes_ES
dc.titleCharacterization of benzodiazepine receptor binding in immature rat brain after kainic acid administrationes_ES
dc.typearticlees_ES
dc.contributor.affiliationCentro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacionales_ES
dc.contributor.emailrocha@cenids.ssa.gob.mxes_ES
dc.relation.jnabreviadoEPILEPSIAes_ES
dc.relation.journalEpilepsiaes_ES
dc.identifier.placeEstados Unidoses_ES
dc.date.published2000es_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñizes_ES
dc.description.abstractotrodiomaTo evaluate the effects of status epilepticus on benzodiazepine (BDZ) receptor binding in immature rat brain. METHODS: Twenty-four immature (15 days old) and six adult (90 days old) rats were used in this study. Status epilepticus was induced in immature animals by administration of kainic acid (7 mg/kg intraperitoneal), whereas adults rats received saline. Animals were killed 72 hours or 35 days after treatment, and their brains were used for in vitro autoradiography experiments to determine BDZ binding. RESULTS: In basal conditions and compared with the adult group, immature animals presented reduced BDZ binding in the entorhinal cortex, substantia nigra pars reticulata, and periaqueductal gray. Seventy-two hours after kainic acid-induced status epilepticus, immature rats showed significantly increased BDZ in the frontal (48%), cingulate (39%), sensorimotor (39%), piriform (57%), and entorhinal (59%) cortices, the medial (84%) and basolateral (27%) amygdaloid nuclei, the dentate gyrus (51%), and the substantia nigra pars reticulata (43%). Thirty-five days after status epilepticus, immature rats displayed decreased BDZ binding in the entorhinal cortex (48%), dentate gyrus (36%), and fields CA1, CA2, and CA3 of Ammon's horn (30%). CONCLUSIONS: The present study demonstrates that status epilepticus and temporal lobe epilepsy produce a characteristic pattern of BDZ binding changes in the immature rat brain that differs from the one previously seen in adultses_ES
dc.subject.kwEpilepsiaes_ES
dc.subject.kwOntogeniaes_ES
dc.subject.kwEstado epilépticoes_ES
dc.subject.kwReceptores de las benzodiazepinases_ES
dc.subject.kwRataes_ES
dc.subject.koEpilepsyes_ES
dc.subject.koOntogenyes_ES
dc.subject.koStatus epilepticuses_ES
dc.subject.koBenzodiazepine receptorses_ES
dc.subject.koRates_ES


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