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Neuropharmacological profile of hydroalcohol extract of Valeriana edulis ssp. procera roots in mice.

dc.creatorOliva, I.
dc.creatorGonzález-Trujano, M.E.
dc.creatorArrieta, J.
dc.creatorEnciso-Rodríguez, R.
dc.creatorNavarrete, A.
dc.date.accessioned2017-06-30T03:41:45Z
dc.date.available2017-06-30T03:41:45Z
dc.date.issued2004es_ES
dc.identifier2113es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/6771
dc.identifier.urihttps://doi.org/10.1002/ptr.1389es_ES
dc.language.isoenges_ES
dc.publisherChichester : Wiley London : Heyden & Son, c1987es_ES
dc.relation18 (4) 290-296 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.titleNeuropharmacological profile of hydroalcohol extract of Valeriana edulis ssp. procera roots in mice.es_ES
dc.typearticlees_ES
dc.contributor.affiliationFacultad de Química, Departamento de Farmacia, Universidad Nacional Autónoma de México, Ciudad Universitaria Coyoacan 04510, México D.F., Méxicoes_ES
dc.relation.jnabreviadoPHYTOTHER RESes_ES
dc.relation.journalPhytotherapy researches_ES
dc.identifier.placeInglaterraes_ES
dc.date.published2004es_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñizes_ES
dc.description.monthAbres_ES
dc.description.abstractotrodiomaValerian is the common name given to the crude drug consisting of the underground organs of the species Valeriana. Valeriana edulis ssp. procera Meyer is the Mexican valerian. The aim of the present work was to elucidate the neuropharmacological profile of a hydroalcohol extract of Valeriana edulis roots at doses of 100, 300 and 1000 mg/kg in several experimental models. A dose-dependent anticonvulsant and anxiolytic-like effect of V. edulis was demonstrated. In addition, the extract decreased rotarod performance and traction force and prolonged the pentobarbital-induced sleeping time at high doses. Concomitant administration of valerian extract and pentobarbital showed a synergistic effect on motor coordination and traction force in mice. The anxiolytic-like effect of V. edulis was compared with diazepam and with diphenhydramine and doxylamine, the latter in order to consider the H(1)-antihistamine effect as another possibility to explain, at least in part, the central nervous system depressant effect of valerian. These results also underlie the medical and industrial use of this species and allowed the conclusion that the extract of V. edulis has central nervous depressant properties similar to, but with some differences to V. of ficinalis, a very well known specieses_ES
dc.subject.meshmAnimalses_ES
dc.subject.meshmAnti-Anxiety Agents-Administration & dosagees_ES
dc.subject.meshmAnti-Anxiety Agents-Pharmacologyes_ES
dc.subject.meshmAnti-Anxiety Agents-Therapeutic usees_ES
dc.subject.meshmAnticonvulsants-Administration & dosagees_ES
dc.subject.meshmAnticonvulsants-Pharmacologyes_ES
dc.subject.meshmAnticonvulsants-Therapeutic usees_ES
dc.subject.meshmDose-Response Relationship, Druges_ES
dc.subject.meshmMalees_ES
dc.subject.meshmMicees_ES
dc.subject.meshmMice, Inbred ICRes_ES
dc.subject.meshmMotor Activity-Drug effectses_ES
dc.subject.meshmPentobarbital-Diagnostic usees_ES
dc.subject.meshmPentylenetetrazole-Diagnostic usees_ES
dc.subject.meshmPhytotherapyes_ES
dc.subject.meshmPlant Extracts-Administration & dosagees_ES
dc.subject.meshmPlant Extracts-Pharmacologyes_ES
dc.subject.meshmPlant Extracts-Therapeutic usees_ES
dc.subject.meshmPlant Rootses_ES
dc.subject.meshmSeizures-Chemically inducedes_ES
dc.subject.meshmSeizures-Prevention & controles_ES
dc.subject.meshmSleep-Drug effectses_ES
dc.subject.meshmValerianes_ES


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