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Antinociceptive effectiveness of triterpenes from rosemary in visceral nociception

dc.creatorMartínez, Ana Laura
dc.creatorGonzález-Trujano, María Eva
dc.creatorChávez, Marco
dc.creatorPellicer, Francisco
dc.date.accessioned2017-06-30T03:41:42Z
dc.date.available2017-06-30T03:41:42Z
dc.date.issued2012es_ES
dc.identifier2111es_ES
dc.identifier.issn0378-8741es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/6769
dc.identifier.urihttps://doi.org/10.1016/j.jep.2012.03.052es_ES
dc.language.isoenges_ES
dc.publisherElsevier Ireland Ltd.es_ES
dc.relation142 (1) 28-34 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.titleAntinociceptive effectiveness of triterpenes from rosemary in visceral nociceptiones_ES
dc.typearticlees_ES
dc.contributor.affiliationLaboratorio deNeurofarmacología de Productos Naturales. Dirección de Investigaciones en Neurociencias, Instituto Nacional de Psiquiatría ‘‘Ramón de la Fuente Muñíz’’, Av. México-Xochimilco No. 101 Col. San Lorenzo Huipulco 14370 México, D.F., Méxicoes_ES
dc.contributor.emailevag@imp.edu.mxes_ES
dc.relation.jnabreviadoJ ETHNOPHARMACOLes_ES
dc.relation.journalJournal of ethnopharmacologyes_ES
dc.identifier.placeIrlandaes_ES
dc.date.published2012es_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñizes_ES
dc.identifier.eissn1872-7573es_ES
dc.identifier.doi10.1016/j.jep.2012.03.052es_ES
dc.description.monthJunes_ES
dc.description.abstractotrodiomaETHNOPHARMACOLOGICAL RELEVANCE: Rosemary is a species used worldwide as a common spice, but also in folk medicine for their therapeutic properties against abdominal pain. The rationale of this study was to examine the involvement of triterpenes and to compare their effectiveness in the antinociceptive effect of an ethanol extract of Rosmarinus officinalis L. (Lamiaceae). MATERIAL AND METHODS: Fractionation and HPLC analyses allowed the identification of a mixture of micromeric (121 mg/g), oleanolic (64 mg/g) and ursolic (83 mg/g) acids as partial antinociceptive responsible in an ethyl acetate fraction of R. officinalis by using the acetic acid-induced abdominal constrictions model in mice. RESULTS: These triterpenes individually evaluated produced a significant and dose-dependent antinociceptive response with similar potency as follows: ED__=1.1 mg/kg (0.9-1.3 mg/kg), 2.1 mg/kg (1.6-2.6 mg/kg) and 1.6 mg/kg (1.1-2.1 mg/kg), respectively, by using the intraperitoneal (i.p.) route of administration in mice. Their maximal antinociceptive efficacy resembled that produced by ketorolac (10 mg/kg, i.p.), a common clinic analgesic. CONCLUSION: Our results provide evidence that these triterpenes participate in the antinociceptive activity of R. officinalis. In addition, each individual triterpene showed a similar potency to that observed with ketorolac, a non-steroidal anti-inflammatory drug, in this experimental modeles_ES
dc.subject.meshmAbdominal pain-Chemically inducedes_ES
dc.subject.meshmAbdominal pain-Drug therapyes_ES
dc.subject.meshmAbdominal pain-Physiopathologyes_ES
dc.subject.meshmAcetic acides_ES
dc.subject.meshmAnalgesics-Analysises_ES
dc.subject.meshmAnalgesics-Therapeutic usees_ES
dc.subject.meshmAnimalses_ES
dc.subject.meshmMalees_ES
dc.subject.meshmMicees_ES
dc.subject.meshmNociception-Drug effectses_ES
dc.subject.meshmPhytotherapyes_ES
dc.subject.meshmPlant components, Aerial-Chemistryes_ES
dc.subject.meshmPlant extracts-Analysises_ES
dc.subject.meshmPlant extracts-Therapeutic usees_ES
dc.subject.meshmPlants Medicinales_ES
dc.subject.meshmRosmarinuses_ES
dc.subject.meshmTriterpenes-Analysises_ES
dc.subject.meshmTriterpenes-Therapeutic usees_ES
dc.subject.kwAntinocicepciónes_ES
dc.subject.kwÁcido micromericoes_ES
dc.subject.kwÁcido oleanólicoes_ES
dc.subject.kwRosmarinus officinalis L.es_ES
dc.subject.kwTriterpenoses_ES
dc.subject.kwÁcido ursólicoes_ES
dc.subject.kwDolor viscerales_ES
dc.subject.koAntinociceptiones_ES
dc.subject.koMicromeric acides_ES
dc.subject.koOleanolic acides_ES
dc.subject.koRosmarinus officinalis L.es_ES
dc.subject.koTriterpeneses_ES
dc.subject.koUrsolic acides_ES
dc.subject.koVisceral paines_ES


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