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Antinociceptive activity of Tilia americana var. mexicana inflorescences and quercetin in the formalin test and in an arthritic pain model in rats.

dc.creatorMartínez, Ana Laura
dc.creatorGonzález-Trujano, Ma. Eva
dc.creatorAguirre-Hernández, Eva
dc.creatorMoreno, Julia
dc.creatorSoto-Hernández, Marco
dc.creatorLópez-Muñoz, Francisco J.
dc.date.accessioned2017-06-30T03:41:40Z
dc.date.available2017-06-30T03:41:40Z
dc.date.issued2009es_ES
dc.identifier2110es_ES
dc.identifier.issn0028-3908es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/6768
dc.identifier.urihttps://doi.org/10.1016/j.neuropharm.2008.10.010es_ES
dc.language.isoenges_ES
dc.publisherElsevier Ltdes_ES
dc.relation56 (2) 564-571 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.titleAntinociceptive activity of Tilia americana var. mexicana inflorescences and quercetin in the formalin test and in an arthritic pain model in rats.es_ES
dc.typearticlees_ES
dc.contributor.affiliationInstituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, Dirección de Investigaciones en Neurociencias, Calz. México-Xochimilco No. 101, Col. San Lorenzo Huipulco, 14370 México, D.F., México. Departamento de Farmacobiología del Cinvestav-Sede Sur, Calz. Tenorios No. 235, Col. Granjas Coapa, C.P. 14330 México, D.F., Méxicoes_ES
dc.contributor.emailevag@imp.edu.mxes_ES
dc.relation.jnabreviadoNEUROPHARMACOLOGYes_ES
dc.relation.journalNeuropharmacologyes_ES
dc.identifier.placeInglaterraes_ES
dc.date.published2009es_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñizes_ES
dc.identifier.eissn1873-7064es_ES
dc.identifier.doi10.1016/j.neuropharm.2008.10.010es_ES
dc.description.monthFebes_ES
dc.description.abstractotrodiomaTilia species are well known around the world for their properties in traditional medicine. Antinociceptive activity of hexane, methanol and aqueous extracts from Tilia americana var. mexicana inflorescences was evaluated in the pain-induced functional impairment model in rats (PIFIR). A preliminar 300 mg/kg dosage of aqueous extracts i.p., but not the same dose of methanol or hexane extract, produced an antinociceptive response in rats similar to that of tramadol (17.8 mg/kg i.p.). A dose-response curve from aqueous extract allowed the determination of ED(50) = 364.97 mg/kg in comparison to ED(50) = 10.35 mg/kg for tramadol in this model. A previous HPLC-DAD analysis corroborated by an HPLC-MS technique in this study demonstrated the flavonoid composition in this Tilia aqueous extract revealing the presence of glycosides mainly derived from quercetin. Thus, Tilia aqueous extract and quercetin were tested at 30 and/or 100 mg/kg dosages i.p. in the PIFIR and formalin models producing a significant and dose-dependent antinociceptive response resembling that produced by a total and a partial agonist of 5-HT(1A) receptors like 8-OH-DPAT (0.1 mg/kg, s.c.) and buspirone (5 mg/kg, i.p.), respectively. In all the treatments, antinociceptive response was inhibited in the presence of WAY 100635 (0.12 mg/kg, i.p.). Our results support the analgesic activity of T. americana var. mexicana inflorescences attributed by folk medicine; they also indicate that quercetin is partly responsible for this pharmacological activity that is likely mediated by serotonin 5-HT(1A) receptorses_ES
dc.subject.meshmAnimalses_ES
dc.subject.meshmArea Under Curvees_ES
dc.subject.meshmArthritis-Diagnosises_ES
dc.subject.meshmArthritis-Etiologyes_ES
dc.subject.meshmBehavior, Animal-Drug effectses_ES
dc.subject.meshmChromatography, High Pressure Liquid-Methodses_ES
dc.subject.meshmDisease Models, Animales_ES
dc.subject.meshmDose-Response Relationship, Druges_ES
dc.subject.meshmDrug Interactionses_ES
dc.subject.meshmMalees_ES
dc.subject.meshmPain-Drug therapyes_ES
dc.subject.meshmPain-Etiologyes_ES
dc.subject.meshmPain Measurement-Methodses_ES
dc.subject.meshmPhytotherapy-Methodses_ES
dc.subject.meshmPiperazines-Pharmacologyes_ES
dc.subject.meshmPlant Extracts-Therapeutic usees_ES
dc.subject.meshmPyridines-Pharmacologyes_ES
dc.subject.meshmQuercetin-Therapeutic usees_ES
dc.subject.meshmRatses_ES
dc.subject.meshmRats, Wistares_ES
dc.subject.meshmSerotonin Antagonists-Pharmacologyes_ES
dc.subject.meshmTiliaes_ES
dc.subject.kwAntinocicepciónes_ES
dc.subject.kwFlavonoideses_ES
dc.subject.kwCromatografía líquida de alta resolución (CLAR)es_ES
dc.subject.kwQuercetinaes_ES
dc.subject.kwTilia americana var. Mexicanaes_ES
dc.subject.kwReceptores 5HT1Aes_ES
dc.subject.koAntinociceptiones_ES
dc.subject.koFlavonoidses_ES
dc.subject.koHPLCes_ES
dc.subject.koQuercetines_ES
dc.subject.koTilia americana var. Mexicanaes_ES
dc.subject.ko5HT1A receptorses_ES


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