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5-HT1A receptor agonists modify epileptic seizures in three experimental models in rats

dc.creatorLópez-Meraz, María-Leonor
dc.creatorGonzález-Trujano, María-Eva
dc.creatorNeri-Bazán, Leticia
dc.creatorHong, Enrique
dc.creatorRocha, Luisa Lilia
dc.date.accessioned2017-06-30T03:41:38Z
dc.date.available2017-06-30T03:41:38Z
dc.date.issued2005es_ES
dc.identifier2108es_ES
dc.identifier.issn0028-3908es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/6767
dc.identifier.urihttps://doi.org/10.1016/j.neuropharm.2005.03.020es_ES
dc.language.isoenges_ES
dc.publisherElsevier Ltdes_ES
dc.relation49 (3) 367-375 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.subject.mesh5-Methoxytryptamine-Analogs & derivativeses_ES
dc.subject.mesh5-Methoxytryptamine-Pharmacologyes_ES
dc.subject.mesh8-Hydroxy-2-(di-n-propylamino) tetralin-Pharmacologyes_ES
dc.subject.meshAmygdalaes_ES
dc.subject.meshAnimalses_ES
dc.subject.meshAnticonvulsantses_ES
dc.subject.meshConvulsantses_ES
dc.subject.meshDose-Response Relationship, Druges_ES
dc.subject.meshEpilepsy, Complex Partial-Prevention & controles_ES
dc.subject.meshEpilepsy, Generalized-Drug therapyes_ES
dc.subject.meshEpilepsyes_ES
dc.subject.meshGeneralized-Physiopathologyes_ES
dc.subject.meshEpilepsy, Tonic-Clonic-Drug therapyes_ES
dc.subject.meshEpilepsy, Tonic-Clonic-Physiopathologyes_ES
dc.subject.meshExcitatory Amino Acid Agonistses_ES
dc.subject.meshKainic Acides_ES
dc.subject.meshKindling, Neurologices_ES
dc.subject.meshMalees_ES
dc.subject.meshPentylenetetrazolees_ES
dc.subject.meshRatses_ES
dc.subject.meshRats, Wistares_ES
dc.subject.meshReceptor, Serotonin, 5-HT1A-Drug effectses_ES
dc.subject.meshSeizures-Drug therapyes_ES
dc.subject.meshSerotonin Receptor Agonists-Pharmacologyes_ES
dc.subject.meshStatus Epilepticus-Chemically Induced Statuses_ES
dc.subject.meshEpilepticus-Prevention & controles_ES
dc.title5-HT1A receptor agonists modify epileptic seizures in three experimental models in ratses_ES
dc.typearticlees_ES
dc.contributor.affiliationDepartamento de Farmacobiología Centro de Investigacion y de Estudios Avanzados, Czda. Tenorios 235. Col. Granjas Coapa 14330 Mexico DF, Mexico.es_ES
dc.relation.jnabreviadoNEUROPHARMACOLOGYes_ES
dc.relation.journalNeuropharmacologyes_ES
dc.identifier.placeInglaterraes_ES
dc.date.published2005es_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñizes_ES
dc.identifier.eissn1873-7064es_ES
dc.identifier.doi10.1016/j.neuropharm.2005.03.020es_ES
dc.description.monthSepes_ES
dc.description.abstractotrodiomaThe effects of two serotonergic (5-HT1A) receptor agonists (8-OH-DPAT; 0.01, 0.1, 0.3, 1 mg/kg, s.c., and Indorenate; 1, 3, 10 mg/kg, i.p.) were evaluated in three type of seizures in male Wistar rats: clonic-tonic convulsions induced by pentylenetetrazol (PTZ, 60 mg/kg, i.p.), status epilepticus (SE) of limbic seizures produced by kainic acid (KA, 10 mg/kg, i.p.) and tonic-clonic seizures by amygdala kindling. 8-OH-DPAT decreased the incidence of tonic seizures and the mortality rate induced by PTZ. Indorenate increased the latency to the PTZ-induced seizures and decreased the percentage of rats showing tonic extension and death. Concerning KA, 8-OH-DPAT augmented the latency and reduced the frequency of wet-dog shake (WDS) and generalized seizure (GS). At high doses it diminished the occurrence and delayed the establishment of SE. Indorenate augmented the latency to WDS, GS and SE, and diminished the number of GS. 8-OH-DPAT and Indorenate did not alter the expression of kindled seizures. However, Indorenate enhanced the refractoriness to subsequent seizures during the postictal depression. Some effects induced by 8-OH-DPAT and Indorenate on seizures evaluated and postictal depression were fully or partially blocked by WAY100635. These results suggest that 5-HT1A receptor agonists modify epileptic activity depending on the type of seizurees_ES
dc.subject.kw8-OH-DPATes_ES
dc.subject.kwIndorrenatoes_ES
dc.subject.kwAgonista de los receptores 5-HT1Aes_ES
dc.subject.kwPentilentetrazoles_ES
dc.subject.kwÁcido kaínicoes_ES
dc.subject.kwAmígdala kindlinges_ES
dc.subject.kwDepresión postictales_ES
dc.subject.ko8-OH-DPATes_ES
dc.subject.koIndorenatees_ES
dc.subject.ko5-HT1A receptor agonistes_ES
dc.subject.koPentylenetetrazolees_ES
dc.subject.koKainic acides_ES
dc.subject.koAmygdala kindlinges_ES
dc.subject.koPostictal depressiones_ES


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