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The acute response of the amygdalar TRH system to psychogenic stressors varies dependent on the paradigm and circadian condition
dc.creator | Gutiérrez-Mariscal, Mariana | |
dc.creator | Sánchez, Edith | |
dc.creator | Rebolledo-Solleiro, Daniela | |
dc.creator | García-Vázquez, Arlene Iskra | |
dc.creator | Cote-Vélez, Antonieta | |
dc.creator | Acasuso-Rivero, Cristina | |
dc.creator | Charli, Jean-Louis | |
dc.creator | Joseph-Bravo, Patricia | |
dc.date.accessioned | 2017-06-30T03:41:33Z | |
dc.date.available | 2017-06-30T03:41:33Z | |
dc.date.issued | 2012 | es_ES |
dc.identifier | 2105 | es_ES |
dc.identifier.issn | 0006-8993 | es_ES |
dc.identifier.uri | http://repositorio.inprf.gob.mx/handle/123456789/6764 | |
dc.identifier.uri | https://doi.org/10.1016/j.brainres.2012.02.071 | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Elsevier B.V. | es_ES |
dc.relation | 1452, 73-84 p. | es_ES |
dc.relation | versión del editor | es_ES |
dc.rights | acceso cerrado | es_ES |
dc.title | The acute response of the amygdalar TRH system to psychogenic stressors varies dependent on the paradigm and circadian condition | es_ES |
dc.type | article | es_ES |
dc.contributor.affiliation | Departamento de Genética del Desarrollo y Fisiología Molecular, Instituto de Biotecnología, Universidad Nacional Autónoma de México (UNAM), Cuernavaca, MOR., Mexico | es_ES |
dc.contributor.email | joseph@ibt.unam.mx | es_ES |
dc.relation.jnabreviado | BRAIN RES | es_ES |
dc.relation.journal | Brain Research | es_ES |
dc.identifier.place | Paises bajos | es_ES |
dc.date.published | 2012 | es_ES |
dc.identifier.organizacion | Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz | es_ES |
dc.identifier.eissn | 1872-6240 | es_ES |
dc.identifier.doi | 10.1016/j.brainres.2012.02.071 | es_ES |
dc.description.month | May | es_ES |
dc.description.abstractotrodioma | Central administration of thyrotropin releasing hormone (TRH) reduces anxiety; amygdalar TRH expression is inversely proportional to the anxious behavior displayed in the elevated plus maze performed during the dark phase (EPM-D). To better understand the role of TRH in amygdala function, we evaluated the expression of TRH and the elements involved in its transmission in various stressful paradigms and how they associated with behavior. Wistar male rats were exposed to restraint (RES), EPM, or the open field test (OFT) and sacrificed 0–60 min afterwards; OFT, RES and EPM were performed during the light (L), and OFT during the dark phase. Restraint increased amygdalar levels of proCRH mRNA, without change in proTRH. All paradigms augmented corticosterone release, highest after OFT-L that also enhanced proCRH mRNA levels and decreased those of proTRH.OFT-D activated the TRHsystem. Levels of anxiety or locomotion were similar in animals tested in light or dark phases but their associationwith biochemical parameters differed. ProTRHexpression and TRHrelease correlated positively with decreased anxiety in EPM-L and in OFT-D. No association with anxiety was detected in OFT-L where proCRH and proTRH expression correlatedwith locomotion supporting their involvement in arousal. The responses of TRH amygdalar systems appeared modulated by the extent of the stress response and by the circadian conditions. Increased proTRHexpression of animals exposed to OFT-Dwas specifically observed in the cortical nucleus of the amygdala, area involved in processing fear stimuli; these TRH neuronsmay thus be part of a circuit with anxiolytic properties | es_ES |
dc.subject.meshm | Amygdala-Metabolism | es_ES |
dc.subject.meshm | Animals Circadian Rhythm-Physiology | es_ES |
dc.subject.meshm | Corticosterone-Blood | es_ES |
dc.subject.meshm | Corticotropin-Releasing Hormone-Metabolism | es_ES |
dc.subject.meshm | Hypothalamo-Hypophyseal System-Metabolism | es_ES |
dc.subject.meshm | Male | es_ES |
dc.subject.meshm | Neurons-Metabolism | es_ES |
dc.subject.meshm | Rats | es_ES |
dc.subject.meshm | Rats, Wistar | es_ES |
dc.subject.meshm | Receptors, Glucocorticoid-Metabolism | es_ES |
dc.subject.meshm | Restraint, Physical | es_ES |
dc.subject.meshm | Stress, Psychological-Metabolism | es_ES |
dc.subject.meshm | Thyrotropin-Releasing Hormone-Metabolism | es_ES |
dc.subject.kw | Hormona liberadora de tirotropina (HLT) | es_ES |
dc.subject.kw | Hormona liberadora de corticotropina (HLC) | es_ES |
dc.subject.kw | Estrés | es_ES |
dc.subject.kw | Ansiedad | es_ES |
dc.subject.kw | Amígdala cortical | es_ES |
dc.subject.kw | Circadiano | es_ES |
dc.subject.kw | Locomoción | es_ES |
dc.subject.kw | Campo abierto | es_ES |
dc.subject.kw | Laberinto plus elevado | es_ES |
dc.subject.kw | Restricción | es_ES |
dc.subject.kw | Corticosterona | es_ES |
dc.subject.ko | TRH | es_ES |
dc.subject.ko | CRH | es_ES |
dc.subject.ko | Stress | es_ES |
dc.subject.ko | Anxiety | es_ES |
dc.subject.ko | Cortical amygdala | es_ES |
dc.subject.ko | Circadian | es_ES |
dc.subject.ko | Locomotion | es_ES |
dc.subject.ko | Open field | es_ES |
dc.subject.ko | Elevated plus maze | es_ES |
dc.subject.ko | Restraint | es_ES |
dc.subject.ko | Corticosterone | es_ES |
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