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dc.creatorGutiérrez-Mariscal, Mariana
dc.creatorSánchez, Edith
dc.creatorGarcía-Vázquez, Arlene
dc.creatorRebolledo-Solleiro, Daniela
dc.creatorCharli, Jean-Louis
dc.creatorJoseph-Bravo, Patricia
dc.date.accessioned2017-06-30T03:41:31Z
dc.date.available2017-06-30T03:41:31Z
dc.date.issued2012es_ES
dc.identifier2104es_ES
dc.identifier.issn0167-0115es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/6763
dc.identifier.urihttps://doi.org/10.1016/j.regpep.2012.08.010es_ES
dc.language.isoenges_ES
dc.publisherElsevier B.V.es_ES
dc.relation179 (1-3) 61-70 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.titleAcute response of hypophysiotropic thyrotropin releasing hormone neurons and thyrotropin release to behavioral paradigms producing varying intensities of stress and physical activityes_ES
dc.typearticlees_ES
dc.contributor.affiliationDepartamento de Genética del Desarrollo y Fisiología Molecular, Instituto de Biotecnología, Universidad Nacional Autónoma de México (UNAM), Cuernavaca MOR., Méxicoes_ES
dc.contributor.emailjoseph@ibt.unam.mxes_ES
dc.relation.jnabreviadoREGUL PEPTes_ES
dc.relation.journalRegulatory peptideses_ES
dc.identifier.placeHolandaes_ES
dc.date.published2012es_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñizes_ES
dc.identifier.eissn1873-1686es_ES
dc.identifier.doi10.1016/j.regpep.2012.08.010es_ES
dc.description.monthNoves_ES
dc.description.abstractotrodiomaThe activity of the hypothalamus–pituitary–thyroid (HPT) axis is essential for energy homeostasis and is differentially modulated by physical and by psychological stress. Contradictory effects of stressful behavioral paradigms on TSH or thyroid hormone release are due to type, length and controllability of the stressor. We hypothesized that an additional determinant of the activity of the HPT axis is the energy demand due to physical activity. We thus evaluated the response of thyrotropin releasing hormone (TRH) neurons of the hypothalamic paraventricular nucleus (PVN) in Wistar male rats submitted to the elevated plus maze (EPM), the open field test (OFT), or restraint, and sacrificed within 1 h after test completion; the response to OFT was compared during light (L) or dark (D) phases. Locomotion and anxiety behaviors were similar if animals were tested in L or D phases but their relation to the biochemical parameters differed. All paradigms increased serum corticosterone concentration; the levels of corticotropin releasing hormone receptor 1 and of glucocorticoid receptor (GR) mRNAs in the PVN were enhanced after restraint or OFT-L. Levels of proTRH mRNA increased in the PVN after exposure to EPM-L or OFT-D; serum levels of thyrotropin (TSH) and T4 only after OFT-D. In contrast, restraint decreased TRH mRNA and serum TSH levels, while it increased TRH content in the mediobasal hypothalamus, implying reduced release. Expression of proTRH in the PVN varied proportionally to the degree of locomotion in OFT-D, while inversely to anxiety in the EPM-L, and to corticosterone in EPM-L and OFT-D. TRH mRNA levels were analyzed by in situ hybridization in the rostral, middle and caudal zones of the PVN in response to OFT-D; they increased in the middle PVN, where most TRH hypophysiotropic neurons reside; levels correlated positively with the velocity attained in the periphery of the OF and negatively, with anxiety. Variations of serum TSH levels correlated positively with locomotor activity in EPM-L and OFT-L or -D, while negatively to serum corticosterone levels in all paradigms. These results support the proposal that the hypophysiotropic PVN TRH neurons are activated by short term physical activity but that this response may be blunted by the inhibitory effect of stresses_ES
dc.subject.meshmAnimalses_ES
dc.subject.meshmAnxietyes_ES
dc.subject.meshmBehavior, Animales_ES
dc.subject.meshmCorticosterone-Bloodes_ES
dc.subject.meshmHypothalamo-Hypophyseal System-Metabolismes_ES
dc.subject.meshmMalees_ES
dc.subject.meshmMaze Learninges_ES
dc.subject.meshmMotor Activityes_ES
dc.subject.meshmNeurons-Metabolismes_ES
dc.subject.meshmParaventricular Hypothalamic Nucleus-Metabolismes_ES
dc.subject.meshmPhotoperiodes_ES
dc.subject.meshmRNA, Messenger-Geneticses_ES
dc.subject.meshmRNA, Messenger-Metabolismes_ES
dc.subject.meshmRatses_ES
dc.subject.meshmRats, Wistares_ES
dc.subject.meshmStress, Psychologicales_ES
dc.subject.meshmThyrotropin-Bloodes_ES
dc.subject.meshmThyrotropin-Secretiones_ES
dc.subject.meshmThyrotropin-Releasing Hormone-Secretiones_ES
dc.subject.kwHormona liberadora de tirotropina (HLT)es_ES
dc.subject.kwHormona liberadora de corticotropina (HLC)es_ES
dc.subject.kwReceptor de glucocorticoides (RG)es_ES
dc.subject.kwHipotálamoes_ES
dc.subject.kwCorticosteronaes_ES
dc.subject.kwLocomociónes_ES
dc.subject.koTRHes_ES
dc.subject.koCRHes_ES
dc.subject.koGRes_ES
dc.subject.koHypothalamuses_ES
dc.subject.koCorticosteronees_ES
dc.subject.koLocomotiones_ES


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