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Palmitone isolated from Annona diversifolia induces an anxiolytic-like effect in mice.

dc.creatorGonzález-Trujano, Ma.Eva
dc.creatorMartínez, Ana Laura
dc.creatorReyes-Ramírez, Adelfo
dc.creatorReyes-Trejo, Benito
dc.creatorNavarrete, Andrés
dc.date.accessioned2017-06-30T03:41:28Z
dc.date.available2017-06-30T03:41:28Z
dc.date.issued2006es_ES
dc.identifier2101es_ES
dc.identifier.issn0032-0943es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/6761
dc.identifier.urihttp://doi.org/10.1055/s-2006-931598es_ES
dc.language.isoenges_ES
dc.relation72 (8) 703-707 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.titlePalmitone isolated from Annona diversifolia induces an anxiolytic-like effect in mice.es_ES
dc.typearticlees_ES
dc.contributor.affiliationDirección de Investigaciones en Neurociencias, Instituto Nacional de Psiquiatría, San Lorenzo Huipulco, México D.F., Méxicoes_ES
dc.contributor.emailevag@imp.edu.mxes_ES
dc.relation.jnabreviadoPLANTA MEDes_ES
dc.relation.journalPlanta medicaes_ES
dc.identifier.placeAlemaniaes_ES
dc.date.published2006es_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñizes_ES
dc.identifier.eissn1439-0221es_ES
dc.description.monthJunes_ES
dc.description.abstractotrodiomaThe aim of this study was to investigate the behavioral effects of palmitone in the anti-anxiety response in experimental models in mice. In the elevated plus-maze test, palmitone (0.3, 1, 3, 10 and 30 mg/kg, I. P.) lengthened, from 50 % to 199 %, the time spent in the open arm region of the maze at all doses tested, as compared to the vehicle group ( P < 0.001). In relation to the rearing activity in the exploratory cylinder, palmitone significantly modified ( P < 0.05), in a dose-dependent manner, this activity by decreasing the number of rearings with an effective dose value (ED (50)) and 95 % confidence limits (CL (50)) of 0.79 (0.23 - 2.68) mg/kg. In addition, in the hole-board test, nose-poking was also significantly decreased ( P < 0.01) in a dose-dependent fashion [ED (50) (CL (50)) = 9.07 (4.51 - 18.26) mg/kg]. Moreover, palmitone at any dose caused no change in motor activity nor disruption in traction performance. In contrast, diazepam, used as reference drug, produced an anxiolytic effect with a significant and dose-dependent decrease in motor coordination accompanied by disruption of the traction performance. Behavioral studies suggest an anti-anxiety effect produced by palmitone, but its neuropharmacological profile differs from that observed for benzodiazepines such as diazepames_ES
dc.subject.meshmAnimals-Annonaes_ES
dc.subject.meshmAnti-Anxiety Agents-Administration & dosagees_ES
dc.subject.meshmAnti-Anxiety Agents-Pharmacologyes_ES
dc.subject.meshmAnti-Anxiety Agents-Therapeutic usees_ES
dc.subject.meshmDose-Response Relationship, Druges_ES
dc.subject.meshmHydrocarbons-Administration & dosagees_ES
dc.subject.meshmHydrocarbons-Pharmacologyes_ES
dc.subject.meshmHydrocarbons-Therapeutic usees_ES
dc.subject.meshmInjections, Intraperitoneales_ES
dc.subject.meshmKetones-Administration & dosagees_ES
dc.subject.meshmKetones-Pharmacologyes_ES
dc.subject.meshmKetones-Therapeutic usees_ES
dc.subject.meshmMalees_ES
dc.subject.meshmMaze Learning-Drug effectses_ES
dc.subject.meshmMicees_ES
dc.subject.meshmMotor Activity-Drug effectses_ES
dc.subject.meshmPhytotherapyes_ES
dc.subject.meshmPlant extracts-Administration & dosagees_ES
dc.subject.meshmPlant Extracts-Pharmacologyes_ES
dc.subject.meshmPlant Extracts-Therapeutic usees_ES
dc.subject.kwAnsiolíticoses_ES
dc.subject.kwComportamiento exploratorioes_ES
dc.subject.kwPalmitonees_ES
dc.subject.koAnnona diverdifolia saffes_ES
dc.subject.koAnnonaceaees_ES
dc.subject.koAnxiolytices_ES
dc.subject.koExploratory behaviores_ES
dc.subject.koPalmitonees_ES


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