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Anti-nociceptive and anti-inflammatory activities of the Agastache mexicana extracts by using several experimental models in rodents

dc.creatorGonzález-Ramírez, Adriana
dc.creatorGonzález-Trujano, María Eva
dc.creatorPellicer, Francisco
dc.creatorLópez-Muñoz, Francisco J.
dc.date.accessioned2017-06-30T03:41:26Z
dc.date.available2017-06-30T03:41:26Z
dc.date.issued2012es_ES
dc.identifier2099es_ES
dc.identifier.issn0378-8741es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/6760
dc.identifier.urihttps://doi.org/10.1016/j.jep.2012.05.044es_ES
dc.language.isoenges_ES
dc.publisherElsevier Ireland Ltdes_ES
dc.relation142 (3) 700-705 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.titleAnti-nociceptive and anti-inflammatory activities of the Agastache mexicana extracts by using several experimental models in rodentses_ES
dc.typearticlees_ES
dc.contributor.affiliationDepartamento deFarmacobiología, Cinvestav-Sur, Calz. De los Tenorios No.235, Col. Granjas Coapa,C.P. 14330, México D.F.,México Laboratorio de Neurofarmacología de Productos Naturales de la Dirección de investigaciones en Neurociencias, Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, Calz. México-Xochimilco 101, Col. Sn Lorenzo Huipulco, 14370. México D.F., Méxicoes_ES
dc.contributor.emailevag@imp.edu.mxes_ES
dc.relation.jnabreviadoJ ETHNOPHARMACOLes_ES
dc.relation.journalJournal of ethnopharmacologyes_ES
dc.identifier.placeIrlandaes_ES
dc.date.published2012es_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñizes_ES
dc.identifier.eissn1872-7573es_ES
dc.identifier.doi10.1016/j.jep.2012.05.044es_ES
dc.description.monthAgoes_ES
dc.description.abstractotrodiomaETHNOPHARMACOLOGICAL RELEVANCE: Agastache mexicana is a plant that has long been used in large demand in Mexican folk medicine to treat pain, among others affections. Nevertheless, no scientific data confirming its use have been reported. The aim of this investigation was to examine the spectrum of antinociceptive activity of A. mexicana by using different experimental models of nociception in rodents. MATERIAL AND METHODS: Nociceptive activity was induced 30 min post treatment of different doses of hexane, ethyl acetate and methanol extracts from A. mexicana aerial parts. The writhing test in mice, and the formalin and plantar tests as well as the pain-induced functional impairment assay in rats (PIFIR model) were the experimental nociceptive models used. Antinociceptive response of the organic extracts was compared to that observed with the analgesic drug tramadol. RESULTS: A. mexicana organic extracts produced a dose-dependent and significant inhibition of the abdominal constrictions caused by 1% acetic acid injection (i.p.) in mice. A maximal antinociceptive effectiveness obtained with tramadol was also observed with the administration of hexane and ethyl acetate extracts in comparison to less effectiveness obtained with the methanol extract. At the same range of doses, A. mexicana organic extracts inhibited the behavioral responses in both phases of the formalin pain test, in which a more intense effect was observed in the inflammatory phase than in the neurogenic stage. With regard to the plantar test and PIFIR model, a significant but not dose-dependent antinociceptive response was observed at specific doses that depended on the organic extract evaluated. CONCLUSION: The antinociceptive activity of A. mexicana aerial parts depends on the intensity of the painful stimulus induced and involves different kinds of constituents. Our present results reinforce the use of this species in traditional medicine and its utility for pain treatment mainly associated with inflammationes_ES
dc.subject.meshmAcetates-Chemistryes_ES
dc.subject.meshmAgastachees_ES
dc.subject.meshmAnalgesics-Therapeutic usees_ES
dc.subject.meshmAnimalses_ES
dc.subject.meshmAnti-Inflammatory Agents-Therapeutic usees_ES
dc.subject.meshmDisease Models, Animales_ES
dc.subject.meshmHexanes-Chemistryes_ES
dc.subject.meshmInflorescence-Chemistryes_ES
dc.subject.meshmMalees_ES
dc.subject.meshmMethanol-Chemistryes_ES
dc.subject.meshmMicees_ES
dc.subject.meshmPain-Drug therapyes_ES
dc.subject.meshmPhytotherapyes_ES
dc.subject.meshmPlant Extracts-Therapeutic usees_ES
dc.subject.meshmRatses_ES
dc.subject.meshmRats, Wistares_ES
dc.subject.meshmSolvents-Chemistryes_ES
dc.subject.meshmStomaches_ES
dc.subject.meshmUlcer-Drug therapyes_ES
dc.subject.kwAgastache mexicana (H. B.K.) Lint y Eplinges_ES
dc.subject.kwSubsp. Xolocotzianaes_ES
dc.subject.kwAntinocicepciónes_ES
dc.subject.kwPrueba de la formalinaes_ES
dc.subject.kwLamiaceaees_ES
dc.subject.kwmodelo PIFIRes_ES
dc.subject.kwEnsayo de retorcimientoes_ES
dc.subject.koAgastache mexicana (H. B.K.)Lint&Eplinges_ES
dc.subject.koSubsp. Xolocotzianaes_ES
dc.subject.koAntinociceptiones_ES
dc.subject.koFormalin testes_ES
dc.subject.koLamiaceaees_ES
dc.subject.koPIFIR modeles_ES
dc.subject.koWrithing testes_ES


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