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Regulation of Cocaine- and Amphetamine-Regulated Transcript- Synthesising Neurons of the Hypothalamic Paraventricular Nucleus by Endotoxin; Implications for Lipopolysaccharide- Induced Regulation of Energy Homeostasis

dc.creatorFüzesi, T.
dc.creatorSánchez, E.
dc.creatorWittmann, G.
dc.creatorSingru, P.S.
dc.creatorFekete, C.
dc.creatorLechan, R.M.
dc.date.accessioned2017-06-30T03:41:22Z
dc.date.available2017-06-30T03:41:22Z
dc.date.issued2008es_ES
dc.identifier2096es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/6757
dc.identifier.urihttps://doi.org/10.1111/j.1365-2826.2008.01758.xes_ES
dc.identifier.urihttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2714541/es_ES
dc.language.isoenges_ES
dc.publisherBritish Society for Neuroendocrinology - Wiley Online Libraryes_ES
dc.relation20 (9) 1058–1066 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.titleRegulation of Cocaine- and Amphetamine-Regulated Transcript- Synthesising Neurons of the Hypothalamic Paraventricular Nucleus by Endotoxin; Implications for Lipopolysaccharide- Induced Regulation of Energy Homeostasises_ES
dc.typearticlees_ES
dc.contributor.affiliationDepartment of Endocrine Neurobiology, Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, Hungaryes_ES
dc.contributor.emailrlechan@tufts-nemc.orges_ES
dc.relation.jnabreviadoJ NEUROENDOCRINOLOGYes_ES
dc.relation.journalJournal of Neuroendocrinologyes_ES
dc.identifier.placeEstados Unidoses_ES
dc.date.published2008es_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñizes_ES
dc.identifier.eissn1365-2826es_ES
dc.identifier.doi10.1111/j.1365-2826.2008.01758.xes_ES
dc.description.monthSepes_ES
dc.description.abstractotrodiomaInfectious diseases and the administration of bacterial lipopolysaccharide (LPS) result in decreased food intake and increased energy expenditure. Because the hypothalamic paraventricular nucleus (PVN) has pivotal roles in the regulation of energy homeostasis and expresses an anorexic peptide, cocaine- and amphetamine-regulated transcript (CART), we hypothesised that increased CART synthesis in this nucleus may contribute to LPS-induced changes in energy homeostasis. Therefore, we studied the effects of intraperitoneal administration of LPS on CART gene expression in the PVN by semiquantitative in situ hybridisation. LPS caused a rapid increase in CART mRNA levels in the PVN. One hour after treatment, the density of silver grains was increased by three-fold in the PVN, and remained elevated 3 h after treatment. Because the dorsal vagal complex, an important vegetative centre in the brainstem, is heavily innervated by CART-containing axons, we determined whether the retrograde tracer, cholera toxin B subunit (CTB), accumulates in CART neurons in the PVN following stereotaxic injection of the tracer into the dorsal vagal complex. One week after injection, CTB accumulated in CART neurons in the ventral, medial, and lateral parvocellular subdivisions of the PVN. In addition, LPS administration induced c-fos expression in a population of CART neurons in the PVN that project to the dorsal vagal complex. These data indicate that increased CART gene expression in neurons of PVN may contribute to LPS-induced anorexia, and suggest that this action may be mediated, at least in part, through a PVN-dorsal vagal complex pathwayes_ES
dc.subject.koCocaine- and amphetamine regulatedes_ES
dc.subject.koTranscriptes_ES
dc.subject.koBacterial lipopolysaccharidees_ES
dc.subject.koHypothalamices_ES
dc.subject.koParaventricular nucleuses_ES
dc.subject.koHypothalamic arcuate nucleuses_ES
dc.subject.koRetrograde tracinges_ES
dc.subject.koDorsal vagal complexes_ES


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