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Differential effects of central leptin, insulin, or glucose administration during fasting on the hypothalamic-pituitary-thyroid axis and feeding-related neurons in the arcuate nucleus

dc.creatorFekete, Csaba
dc.creatorSingru, Praful S.
dc.creatorSánchez, Edith
dc.creatorSarkar, Sumit
dc.creatorChristoffolete, Marcelo A.
dc.creatorRiberio, Rogerio S.
dc.creatorRand, William M.
dc.creatorEmerson, Charles H.
dc.creatorBianco, Antonio C.
dc.creatorLechan, Ronald M.
dc.date.accessioned2017-06-30T03:41:21Z
dc.date.available2017-06-30T03:41:21Z
dc.date.issued2006es_ES
dc.identifier2094es_ES
dc.identifier.issn0013-7227es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/6756
dc.identifier.urihttps://doi.org/10.1210/en.2005-0956es_ES
dc.language.isoenges_ES
dc.publisherLos Angeles, Calif. : Association for the Study of Internal Secretions, Chevy Chase, MD : Endocrine Societyes_ES
dc.relation147 (1) 520-529 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.titleDifferential effects of central leptin, insulin, or glucose administration during fasting on the hypothalamic-pituitary-thyroid axis and feeding-related neurons in the arcuate nucleuses_ES
dc.typearticlees_ES
dc.contributor.affiliationTupper Research Institute and Department of Medicine (C.F., P.S.S., E.S., S.S., R.M.L.), Division of Endocrinology,es_ES
dc.relation.jnabreviadoENDOCRINOLOGYes_ES
dc.relation.journalEndocrinologyes_ES
dc.identifier.placeEstados Unidoses_ES
dc.date.published2006es_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñizes_ES
dc.identifier.eissn1945-7170es_ES
dc.identifier.doi10.1210/en.2005-0956es_ES
dc.description.monthEnees_ES
dc.description.abstractotrodiomaThe reductions in circulating levels of leptin, insulin, and glucose with fasting serve as important homeostasis signals to neurons of the hypothalamic arcuate nucleus that synthesize neuropeptide Y (NPY)/agouti-related protein (AGRP) and alpha-MSH/cocaine and amphetamine-regulated transcript. Because the central administration of leptin is capable of preventing the inhibitory effects of fasting on TRH mRNA in hypophysiotropic neurons primarily through effects on the arcuate nucleus, we determined whether the continuous administration of 30 mU/d insulin or 648 microg/d glucose into the cerebrospinal fluid by osmotic minipump might also have similar effects on the hypothalamic-pituitary-thyroid axis. As anticipated, the intracerebroventricular infusion of leptin reduced fasting-induced elevations in NPY and AGRP mRNA and increased proopiomelanocortin and cocaine and amphetamine-regulated transcript mRNA in the arcuate nucleus. In addition, leptin prevented fasting-induced reduction in pro-TRH mRNA levels in the paraventricular nucleus and in circulating thyroid hormone levels. In contrast, whereas insulin increased proopiomelanocortin mRNA and both insulin and glucose reduced NPY mRNA in arcuate nucleus neurons, neither prevented the fasting-induced suppression in hypophysiotropic TRH mRNA or circulating thyroid hormone levels. We conclude that insulin and glucose only partially replicate the central effects of leptin and may not be essential components of the hypothalamic-pituitary-thyroid regulatory system during fastinges_ES
dc.subject.meshmAgouti Signaling Proteines_ES
dc.subject.meshmAnimalses_ES
dc.subject.meshmArcuate Nucleus-Drug effectses_ES
dc.subject.meshmArcuate Nucleus-Physiologyes_ES
dc.subject.meshmCocaine-Pharmacologyes_ES
dc.subject.meshmFasting-Physiologyes_ES
dc.subject.meshmFeeding Behavior-Drug effectses_ES
dc.subject.meshmFeeding Behavior-Physiologyes_ES
dc.subject.meshmGlucose-Administration & dosagees_ES
dc.subject.meshmGlucose-Pharmacologyes_ES
dc.subject.meshmHypothalamo-Hypophyseal System-Drug effectses_ES
dc.subject.meshmHypothalamo-Hypophyseal System-Physiologyes_ES
dc.subject.meshmInsulin-Administration & dosagees_ES
dc.subject.meshmInsulin-Pharmacologyes_ES
dc.subject.meshmIntercellular Signaling Peptides and Proteins-Geneticses_ES
dc.subject.meshmLeptin-Administration & dosagees_ES
dc.subject.meshmLeptin-Pharmacologyes_ES
dc.subject.meshmMalees_ES
dc.subject.meshmNeurons-Drug effectses_ES
dc.subject.meshmNeurons-Physiologyes_ES
dc.subject.meshmNeuropeptide Y-Geneticses_ES
dc.subject.meshmRNA, Messenger-Geneticses_ES
dc.subject.meshmRatses_ES
dc.subject.meshmRats, Sprague-Dawleyes_ES
dc.subject.meshmThyroid Gland-Drug effectses_ES
dc.subject.meshmThyroid Gland-Physiologyes_ES
dc.subject.meshmThyrotropin-Geneticses_ES
dc.subject.meshmTranscription, Genetic-Drug effectses_ES
dc.subject.kwLeptina, insulina o glucosaes_ES
dc.subject.kwEje tiroideo pituitaria hipotalámicaes_ES
dc.subject.kwAlimentar neuronases_ES
dc.subject.kwNúcleo arqueadoes_ES
dc.subject.koLeptin, insulin or glucosees_ES
dc.subject.koHypothalamic pituitary thyroid axises_ES
dc.subject.koFeeding neuronses_ES
dc.subject.koArcuate nucleuses_ES


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