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Antinociceptive activity of Annona diversifolia Saff. leaf extracts and palmitone as a bioactive compound

dc.creatorCarballo, Azucena I.
dc.creatorMartínez, Ana Laura
dc.creatorGonzález-Trujano, Ma. Eva
dc.creatorPellicer, Francisco
dc.creatorVentura-Martínez, Rosa
dc.creatorDíaz-Reval, M. Irene
dc.creatorLópez-Muñoz, Francisco J.
dc.date.accessioned2017-06-30T03:41:17Z
dc.date.available2017-06-30T03:41:17Z
dc.date.issued2010es_ES
dc.identifier2091es_ES
dc.identifier.issn0091-3057es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/6754
dc.identifier.urihttps://doi.org/10.1016/j.pbb.2009.11.017es_ES
dc.language.isoenges_ES
dc.publisherPhoenix, N. Y. Ankho International, ltd. Tarrytown, NY : Elsevieres_ES
dc.relation95 (1) 6-12 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.titleAntinociceptive activity of Annona diversifolia Saff. leaf extracts and palmitone as a bioactive compoundes_ES
dc.typearticlees_ES
dc.contributor.affiliationInstituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, Calz. México-Xochimilco No. 101 Col. Sn Lorenzo Huipulco 14370, México, D.F. Méxicoes_ES
dc.contributor.emailevag@imp.edu.mxes_ES
dc.relation.jnabreviadoPHARMACOL BIOCHEM BEHAVes_ES
dc.relation.journalPharmacology, biochemistry, and behaviores_ES
dc.identifier.placeUnited Stateses_ES
dc.date.published2010es_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñizes_ES
dc.identifier.eissn1873-5177es_ES
dc.identifier.doi10.1016/j.pbb.2009.11.017es_ES
dc.description.monthMares_ES
dc.description.abstractotrodiomaAnnonas are consumed as fresh fruits, but are also widely used in folk medicine for treating pain and other ailments. Antinociceptive properties of the Annona diversifolia ethanol crude extract were tested using the pain-induced functional impairment model in rat (PIFIR) and the writhing test in mice. The ethanol extract caused a 25% recovery of limb function in rats; this response was significant and dose-dependent. Furthermore, this extract produced a similar antinociceptive response (ED(50)=15.35 mg/kg) to that of the reference drug tramadol (ED(50)=12.42 mg/kg) when evaluated in the writhing test in mice. Bio-guided fractionation yielded hexane and acetone active fractions from which the presence of palmitone and flavonoids was respectively detected. Palmitone produced an antinociceptive response with an ED(50)=19.57 mg/kg in the writhing test. Antinociceptive responses from ethanol extract and tramadol were inhibited in the presence of either naloxone (1mg/kg, s.c.)--an antagonist of endogenous opioids--or WAY100635 (0.8 mg/kg, s.c.)--a 5-HT(1A) serotonin receptor antagonist. These results provide evidence that A. diversifolia possesses antinociceptive activity, giving support to their traditional use for treatment of spasmodic and arthritic pain. In addition, our results suggest the participation of endogenous opioids and 5-HT(1A) receptors in this antinociceptive responsees_ES
dc.subject.meshmAnalgesics-Pharmacologyes_ES
dc.subject.meshmAnimalses_ES
dc.subject.meshmAnnona-Chemistryes_ES
dc.subject.meshmHydrocarbons-Pharmacologyes_ES
dc.subject.meshmKetones-Pharmacologyes_ES
dc.subject.meshmLethal Dose 50es_ES
dc.subject.meshmMicees_ES
dc.subject.meshmPlant Extracts-Pharmacologyes_ES
dc.subject.meshmPlant Leaves-Chemistryes_ES
dc.subject.meshmRatses_ES
dc.subject.koAnnona diversifolia Saff.es_ES
dc.subject.koAnnonaceaees_ES
dc.subject.koAntinociceptiones_ES
dc.subject.koEndogenous opioidses_ES
dc.subject.koPalmitonees_ES
dc.subject.ko5HT1Aes_ES


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