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Palmitone prevents pentylenetetrazole-caused neuronal damage in the CA3 hippocampal region of prepubertal rats

dc.creatorCano-Europa, E.
dc.creatorGonzález-Trujano, M.E.
dc.creatorReyes-Ramírez, A.
dc.creatorHernández-García, A.
dc.creatorBlas-Valdivia, V.
dc.creatorOrtíz-Butrón, R.
dc.date.accessioned2017-06-30T03:41:16Z
dc.date.available2017-06-30T03:41:16Z
dc.date.issued2010es_ES
dc.identifier2090es_ES
dc.identifier.issn0304-3940es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/6753
dc.identifier.urihttps://doi.org/10.1016/j.neulet.2009.12.066es_ES
dc.language.isoenges_ES
dc.publisherElsevier/North-Holland Limerick : Elsevier Scientific Publishers Irelandes_ES
dc.relation470 (2) 111-114 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.titlePalmitone prevents pentylenetetrazole-caused neuronal damage in the CA3 hippocampal region of prepubertal ratses_ES
dc.typearticlees_ES
dc.contributor.affiliationDepartamento de Fisiología “Mauricio Russek Berman”, Escuela Nacional de Ciencias Biológicas, I.P.N., Carpio y Plan de Ayala, México, D.F., C.P.11340, Mexicoes_ES
dc.contributor.emailrocipn@yahoo.com.mxes_ES
dc.relation.jnabreviadoNEUROSCI LETTes_ES
dc.relation.journalNeuroscience letterses_ES
dc.identifier.placeIrelandes_ES
dc.date.published2010es_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñizes_ES
dc.identifier.eissn1872-7972es_ES
dc.identifier.doi10.1016/j.neulet.2009.12.066es_ES
dc.description.monthFebes_ES
dc.description.abstractotrodiomaPalmitone is a secondary metabolite of polyketide origin extracted from leaves of Annona diversifolia Saff. (Annonaceae). We found that palmitone possesses anticonvulsant properties against penicillin-, 4-AP-, and pentylenetetrazole (PTZ)-caused seizure in adult animals. Some convulsants as PTZ cause neuronal damage in different brain regions such as the CA3 hippocampal region. Our objective was to evaluate if palmitone protects against PTZ-caused seizures and hippocampal neuronal damage in prepubertal rats. We used 32 prepubertal Wistar rats (30-35 days old) divided into four groups of 8 animals; group I was the control group, group II received a single PTZ dose of 50mg/kg ip, group III received a single palmitone dose of 50mg/kg ip, and group IV received a palmitone dose of 50mg/kg ip plus a PTZ dose of 50mg/kg ip. Ten days after administration, the animals were killed using pentobarbital anesthesia (35 mg/kg). The brains were removed and were embedded in paraffin. Coronal cuts of 7 microm were obtained from -2.8 to -3.3 from Bregma. Each section was stained with cresyl violet-eosin. We evaluated the number of normal and abnormal neurons in the CA3 hippocampal region in a 10,000 microm(2) section. It was observed that palmitone did not prevent the PTZ-caused seizure but palmitone prevents the PTZ-caused neuronal damage in the CA3 hippocampal regiones_ES
dc.subject.meshmAginges_ES
dc.subject.meshmAnimalses_ES
dc.subject.meshmCA3 Region, Hippocampal-Drug effectses_ES
dc.subject.meshmCA3 Region, Hippocampal-Pathologyes_ES
dc.subject.meshmCell Countes_ES
dc.subject.meshmConvulsants-Toxicityes_ES
dc.subject.meshmHydrocarbons-Pharmacologyes_ES
dc.subject.meshmKetones-Pharmacologyes_ES
dc.subject.meshmNeurons-Drug effectses_ES
dc.subject.meshmNeurons-Pathologyes_ES
dc.subject.meshmNeuroprotective Agents-Pharmacologyes_ES
dc.subject.meshmPentylenetetrazole-Toxicityes_ES
dc.subject.meshmPhotomicrographyes_ES
dc.subject.meshmPyramidal Cells-Drug effectses_ES
dc.subject.meshmPyramidal Cells-Pathologyes_ES
dc.subject.meshmRandom Allocationes_ES
dc.subject.meshmRatses_ES
dc.subject.meshmRats, Wistares_ES
dc.subject.meshmSeizures-Chemically inducedes_ES
dc.subject.meshmSeizures-Drug therapyes_ES
dc.subject.meshmSeizures-Pathologyes_ES
dc.subject.meshmTime Factorses_ES
dc.subject.kwPalmitonees_ES
dc.subject.kwAnticonvulsivaes_ES
dc.subject.kwDecomisoes_ES
dc.subject.kwDaño neuronales_ES
dc.subject.koPalmitonees_ES
dc.subject.koAnticonvulsantes_ES
dc.subject.koSeizurees_ES
dc.subject.koNeuronal damagees_ES


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