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Food-Restricted and Dehydrated-Induced Anorexic Rats Present Differential TRH Expression in Anterior and Caudal PVN. Role of Type 2 Deiodinase and Pyroglutamyl Aminopeptidase II
dc.creator | Alvarez-Salas, E. | |
dc.creator | Aceves, C. | |
dc.creator | Anguiano, B. | |
dc.creator | Uribe, R.M. | |
dc.creator | García-Luna, C. | |
dc.creator | Sánchez, E. | |
dc.creator | De Gortari, P. | |
dc.date.accessioned | 2017-06-30T03:40:59Z | |
dc.date.available | 2017-06-30T03:40:59Z | |
dc.date.issued | 2012 | es_ES |
dc.identifier | 2075 | es_ES |
dc.identifier.issn | 0013-7227 | es_ES |
dc.identifier.uri | http://repositorio.inprf.gob.mx/handle/123456789/6739 | |
dc.identifier.uri | https://doi.org/10.1210/en.2011-2011 | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | The Endocrine Society | es_ES |
dc.relation | 153 (8) 4067–4076 p. | es_ES |
dc.relation | versión del editor | es_ES |
dc.rights | acceso cerrado | es_ES |
dc.title | Food-Restricted and Dehydrated-Induced Anorexic Rats Present Differential TRH Expression in Anterior and Caudal PVN. Role of Type 2 Deiodinase and Pyroglutamyl Aminopeptidase II | es_ES |
dc.type | article | es_ES |
dc.contributor.affiliation | Neurofisiología Molecular (E.A.-S., C.G.-L., P.de.G.) | es_ES |
dc.contributor.email | gortari@imp.edu.mx. | es_ES |
dc.relation.jnabreviado | ENDOCRINOLOGY | es_ES |
dc.relation.journal | Endocrinology | es_ES |
dc.identifier.place | United States | es_ES |
dc.date.published | 2012 | es_ES |
dc.identifier.organizacion | Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz | es_ES |
dc.identifier.eissn | 1945-7170 | es_ES |
dc.identifier.doi | 10.1210/en.2011-2011 | es_ES |
dc.description.month | Ago | es_ES |
dc.description.abstractotrodioma | TRH synthesized in hypothalamic paraventricular nucleus (PVN) regulates thyroid axis function and is also implicated in anorexigenic effects. Under energy deficit, animals present decreasedPVNTRH expression and release, low TSH levels, and increased appetite. Dehydration-induced anorexia (DIA) model allows insight into underlying mechanisms of feeding regulation. Animals drinking a 2.5% NaCl solution for 7 d present body weight reduction; despite their negative energy balance, they avoid food and have increased PVN TRH expression and TSH serum levels. These findings support an inhibiting role of PVN TRH in feeding control. We compared TRH expression by in situ hybridization in PVN subdivisions of 7-d dehydrated male rats to those of a pair-fed group (forced food-restricted) with similar metabolic changes than DIA, but motivated to eat, and to controls.We measured peripheral deiodinase activities, and expression and activity of medial basal hypothalamic type 2 deiodinaseandpyroglutamyl-aminopeptidase II, to understand their regulating role inPVNTRH changes between food restriction and anorexia. TRH mRNA levels increased in anterior (aPVN) and medial-caudal subdivisions in DIA rats, whereas it decreased in medial PVN in both experimental groups. We confirmed the nonhypophysiotropic nature of aPVN TRHergic cells by injecting ip fluorogold tracer. Findings support a subspecialization of TRHergic hypophysiotrophic cells that responded differently between anorexic and food-restricted animals; also, that aPVN TRH participates in food intake regulation. Increased type 2 deiodinase activity seemed responsible for low medial PVN TRH synthesis,whereasincreasedmedialbasalhypothalamicpyroglutamyl-aminopeptidaseII activity inDIA rats might counteract their high TRH release | es_ES |
dc.subject.meshm | Aminopeptidases-Genetics | es_ES |
dc.subject.meshm | Aminopeptidases-Metabolism | es_ES |
dc.subject.meshm | Animals | es_ES |
dc.subject.meshm | Anorexia-Etiology | es_ES |
dc.subject.meshm | Anorexia-Metabolism | es_ES |
dc.subject.meshm | Body Weight-Physiology | es_ES |
dc.subject.meshm | Caloric Restriction | es_ES |
dc.subject.meshm | Dehydration | es_ES |
dc.subject.meshm | Eating-Physiology | es_ES |
dc.subject.meshm | In Situ Hybridization | es_ES |
dc.subject.meshm | Iodide Peroxidase-Genetics | es_ES |
dc.subject.meshm | Iodide Peroxidase-Metabolism | es_ES |
dc.subject.meshm | Male | es_ES |
dc.subject.meshm | Paraventricular Hypothalamic Nucleus-Metabolism | es_ES |
dc.subject.meshm | Pyrrolidonecarboxylic Acid-Analogs & derivatives | es_ES |
dc.subject.meshm | Pyrrolidonecarboxylic Acid-Metabolism | es_ES |
dc.subject.meshm | Rats | es_ES |
dc.subject.meshm | Reverse Transcriptase Polymerase Chain Reaction | es_ES |
dc.subject.meshm | Thyrotropin-Releasing Hormone-Genetics | es_ES |
dc.subject.meshm | Thyrotropin-Releasing Hormone-Metabolism | es_ES |
dc.subject.kw | Ratas | es_ES |
dc.subject.kw | Alimentos restringidos | es_ES |
dc.subject.kw | Anorexia | es_ES |
dc.subject.kw | Deiodinase y Piroglutamil Aminopeptidasa II | es_ES |
dc.subject.ko | Deiodinase and Pyroglutamyl Aminopeptidase II | es_ES |
dc.subject.ko | Rats | es_ES |
dc.subject.ko | Food-Restricted | es_ES |
dc.subject.ko | Anorexia | es_ES |
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