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Bioactivity-guided isolation of beta-sitosterol and some fatty acids as active compounds in the anxiolytic and sedative effects of Tilia americana var. Mexicana

dc.creatorAguirre-Hernández, Eva
dc.creatorRosas-Acevedo, Hortensia
dc.creatorSoto-Hernández, Marcos
dc.creatorMartínez, Ana Laura
dc.creatorMoreno, Julia
dc.creatorGonzález-Trujano, Ma. Eva
dc.date.accessioned2017-06-30T03:40:58Z
dc.date.available2017-06-30T03:40:58Z
dc.date.issued2007es_ES
dc.identifier2074es_ES
dc.identifier.issn0032-0943es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/6738
dc.identifier.urihttp://doi.org/10.1055/s-2007-981593es_ES
dc.language.isoenges_ES
dc.publisherStuttgart, Hippokrates Verlag Stuttgart ; New York : George Thiemees_ES
dc.relation73 (11) 1148-1155 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.titleBioactivity-guided isolation of beta-sitosterol and some fatty acids as active compounds in the anxiolytic and sedative effects of Tilia americana var. Mexicanaes_ES
dc.typearticlees_ES
dc.contributor.affiliationInstituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, México, D. F., Mexico.es_ES
dc.relation.jnabreviadoPLANTA MEDes_ES
dc.relation.journalPlanta medicaes_ES
dc.identifier.placeGermanyes_ES
dc.date.published2007es_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñizes_ES
dc.identifier.eissn1439-0221es_ES
dc.description.monthSepes_ES
dc.description.abstractotrodiomaTilia species have been used as anxiolytics for many years. In a previous study anxiolytic-like effects of a hexane extract of Tilia americana var. mexicana inflorescences were observed in experimental models in mice. To get additional insights into the neuroactive actions of this particular Tilia species, in this study we report a bioactivity guided-fractionation of the extract and separation by column chromatographic methods to isolate three fatty acids and a triterpene identified as beta-sitosterol as major constituents. Our results revealed that the crude extract at 10 and 30 mg/kg I. P. and some pooled fractions at the same dosages potentiated sodium pentobarbital-induced sleeping time and caused a significant increase in the time spent at the open-arm sides in the plus-maze test. A reduction in the exploratory behavioral pattern manifested as ambulatory activity, as well as head dipping and rearing tests was also observed. Further fractionation and purification yielded four major fractions containing fatty acids and beta-sitosterol as the active compounds. A dose-response curve of beta-sitosterol in the range 1 to 30 mg/kg doses indicated that this compound produced an anxiolytic-like action from 1 to 10 mg/kg and a sedative response when the dose was increased to 30 mg/kg, these effects resemble those produced by diazepam (0.1 mg/kg). Our results suggest that hexane extract of Tilia americana var. mexicana produces depressant actions on the central nervous system, at least in part, because of the presence of beta-sitosterol and some fatty acids that remain to be identifiedes_ES
dc.subject.meshmAnimalses_ES
dc.subject.meshmAnti-Anxiety Agents-Administration & dosagees_ES
dc.subject.meshmAnti-Anxiety Agents-Pharmacologyes_ES
dc.subject.meshmAnti-Anxiety Agents-Therapeutic usees_ES
dc.subject.meshmDose-Response Relationship, Druges_ES
dc.subject.meshmFatty Acids-Administration & dosagees_ES
dc.subject.meshmFatty Acids-Pharmacologyes_ES
dc.subject.meshmFatty Acids-Therapeutic usees_ES
dc.subject.meshmInjections, Intraperitoneales_ES
dc.subject.meshmMalees_ES
dc.subject.meshmMaze Learning-Drug effectses_ES
dc.subject.meshmMicees_ES
dc.subject.meshmPhytotherapyes_ES
dc.subject.meshmPlant Extracts-Administration & dosagees_ES
dc.subject.meshmPlant Extracts-Pharmacologyes_ES
dc.subject.meshmPlant Extracts-Therapeutic usees_ES
dc.subject.meshmSitosterols-Administration & dosagees_ES
dc.subject.meshmSitosterols-Pharmacologyes_ES
dc.subject.meshmSitosterols-Therapeutic usees_ES
dc.subject.meshmSleep-Drug effectses_ES
dc.subject.meshmTiliaes_ES
dc.subject.kwBeta-sitosteroles_ES
dc.subject.kwSistema nervioso centrales_ES
dc.subject.kwSedantees_ES
dc.subject.kwTilia americana var. mexicanaes_ES
dc.subject.kwTiliaceaees_ES
dc.subject.koAnxietyes_ES
dc.subject.koBeta-sitosteroles_ES
dc.subject.koCentral nervous systemes_ES
dc.subject.koSedativees_ES
dc.subject.koTilia americana var. mexicanaes_ES
dc.subject.koTiliaceaees_ES


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