Mostrar el registro sencillo del ítem

Pharmacological evaluation of the anxiolytic and sedative effects of Tilia americana L. var. mexicana in mice

dc.creatorAguirre-Hernández, E.
dc.creatorMartínez , A.L.
dc.creatorGonzález-Trujano, M.E.
dc.creatorMoreno, J.
dc.creatorVibrans, H.
dc.creatorSoto-Hernández, M.
dc.date.accessioned2017-06-30T03:40:57Z
dc.date.available2017-06-30T03:40:57Z
dc.date.issued2007es_ES
dc.identifier2072es_ES
dc.identifier.issn0378-8741es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/6737
dc.identifier.urihttps://doi.org/10.1016/j.jep.2006.07.017es_ES
dc.language.isoenges_ES
dc.relation109 (1) 140-145 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.titlePharmacological evaluation of the anxiolytic and sedative effects of Tilia americana L. var. mexicana in micees_ES
dc.typearticlees_ES
dc.contributor.affiliationInstituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, Calz. México-Xochimilco No. 101, Col. Sn Lorenzo Huipulco, Delegación Tlalpan 14370, México, D.F., Méxicoes_ES
dc.contributor.emailevag@imp.edu.mxes_ES
dc.relation.jnabreviadoJ ETHNOPHARMACOLes_ES
dc.relation.journalJournal of ethnopharmacologyes_ES
dc.identifier.placeIrelandes_ES
dc.date.published2007es_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñizes_ES
dc.identifier.eissn1872-7573es_ES
dc.description.monthEnees_ES
dc.description.abstractotrodiomaThe anxiolytic and sedative effects of Tilia americana L. var. mexicana (Schltdl.) Hardin inflorescence extracts and its acute toxicity were tested. Sodium pentobarbital (SP)-induced hypnosis potentiation (SPP), as well as ambulatory activity and anti-anxiety response in three different experimental models were evaluated with hexane and methanol extracts in mice. In order to determine the proper timing of assessments and to identify the most active extract, a 100 mg/kg dosage of hexane, ethyl acetate and methanol crude extracts were tested on SPP after 15, 30 and 60 min of the administration. Then a dose–response curve was made for the hexane (10–1000 mg/kg) and methanol (10–300 mg/kg) extracts in all experimental models. Both extracts produced a significant and dose-dependent lengthening in the time of SP, with the methanol extract being more potent than the hexane extract at 60 min after administration. Moreover, a significant and dose-dependent attenuation in the anxiety-response in the plus-maze test and exploratory cylinder activity, but also a diminution in the ambulatory activity and in the head dipping response were observed resembling the response to diazepam. Acute toxicity was observed with less dose of methanol extract (LD50 = 375 mg/kg) in comparison to the hexane extract (LD50 > 2900 mg/kg). Results of the present study shows that Tilia americana var. mexicana possesses depressant activity on the CNS similar to the better-studied species of European Tilia and reinforces its use as anxiolytic and sedative in traditional medicine. Des_ES
dc.subject.meshmAnimalses_ES
dc.subject.meshmAnti-Anxiety Agents-Chemistryes_ES
dc.subject.meshmAnti-Anxiety Agents-Pharmacologyes_ES
dc.subject.meshmDiazepam-Pharmacologyes_ES
dc.subject.meshmDose-Response Relationship, Druges_ES
dc.subject.meshmExploratory Behavior-Drug effectses_ES
dc.subject.meshmHexaneses_ES
dc.subject.meshmHypnotics and Sedatives-Chemistryes_ES
dc.subject.meshmHypnotics and Sedatives-Pharmacologyes_ES
dc.subject.meshmInjections, Intraperitoneales_ES
dc.subject.meshmLethal Dose 50es_ES
dc.subject.meshmMalees_ES
dc.subject.meshmMethanoles_ES
dc.subject.meshmMicees_ES
dc.subject.meshmMotor Activity-Drug effectses_ES
dc.subject.meshmPentobarbital-Pharmacologyes_ES
dc.subject.meshmPlant Extracts-Pharmacologyes_ES
dc.subject.meshmPlant Extracts-Toxicityes_ES
dc.subject.meshmSolventses_ES
dc.subject.meshmTilia-Chemistryes_ES
dc.subject.meshmTilia-Toxicityes_ES
dc.subject.kwAnsiolíticoses_ES
dc.subject.kwSistema nervioso centrales_ES
dc.subject.kwSedante-hipnóticoes_ES
dc.subject.kwTilia americana L. var. Mexicanaes_ES
dc.subject.koAnxiolytices_ES
dc.subject.koCentral nervous systemes_ES
dc.subject.koSedative-hypnotices_ES
dc.subject.koTilia americana L. var. Mexicanaes_ES


Ficheros en el ítem

FicherosTamañoFormatoVer

No hay ficheros asociados a este ítem.

Este ítem aparece en la(s) siguiente(s) colección(ones)

Mostrar el registro sencillo del ítem