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Altered cardiovascular reactivity and osmoregulation during hyperosmotic stress in adult rats developmentally exposed to polybrominated diphenyl ethers (PBDEs)

dc.creatorShah, Ashini
dc.creatorCoburn, Cary G.
dc.creatorWatson-Siriboe, Abena
dc.creatorWhitley, Rebecca
dc.creatorShahidzadeh, Anoush
dc.creatorGillard, Elizabeth R.
dc.creatorNichol, Robert
dc.creatorLeón-Olea, Martha
dc.creatorGaertner, Mark
dc.creatorKodavanti, Prasada Rao S.
dc.creatorCurrás-Collazo, Margarita C.
dc.date.accessioned2017-06-30T02:06:08Z
dc.date.available2017-06-30T02:06:08Z
dc.date.issued2011es_ES
dc.identifier1525es_ES
dc.identifier.issn0041-008Xes_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/6204
dc.identifier.urihttps://doi.org/10.1016/j.taap.2011.07.014es_ES
dc.language.isoenges_ES
dc.relation256 (2) 103-113 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.titleAltered cardiovascular reactivity and osmoregulation during hyperosmotic stress in adult rats developmentally exposed to polybrominated diphenyl ethers (PBDEs)es_ES
dc.typearticlees_ES
dc.contributor.affiliationDepartment of Cell Biology and Neuroscience, University of California, Riverside, CA 92521, USA.es_ES
dc.contributor.emailmargarita.curras@ucr.edues_ES
dc.relation.jnabreviadoTOXICOL APPL PHARMACOLes_ES
dc.relation.journalToxicology and Applied Pharmacologyes_ES
dc.identifier.placeEstados Unidoses_ES
dc.date.published2011es_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñizes_ES
dc.identifier.eissn1096-0333es_ES
dc.identifier.doi10.1016/j.taap.2011.07.014es_ES
dc.description.monthOctes_ES
dc.description.abstractotrodiomaPolybrominated diphenyl ethers (PBDEs) and the structurally similar chemicals polychlorinated biphenyls (PCBs) disrupt the function of multiple endocrine systems. PCBs and PBDEs disrupt the secretion of vasopressin (VP) from the hypothalamus during osmotic activation. Since the peripheral and central vasopressinergic axes are critical for osmotic and cardiovascular regulation, we examined whether perinatal PBDE exposure could impact these functions during physiological activation. Rats were perinatally dosed with a commercial PBDE mixture, DE-71. Dams were given 0 (corn oil control), 1.7 (low dose) or 30.6 mg-kg-day (high dose) in corn oil from gestational day (GD) 6 through postnatal day (PND) 21 by oral gavage. In the male offspring exposed to high dose PBDE plasma thyroxine and triiodothyronine levels were reduced at PND 21 and recovered to control levels by PND 60 when thyroid stimulating hormone levels were elevated. At 14-18 months of age, cardiovascular responses were measured in four groups of rats: Normal (Oil, normosmotic condition), Hyper (Oil, hyperosmotic stress), Hyper PBDE low (1.7 mg-kg-day DE-71 perinatally, hyperosmotic stress), and Hyper PBDE high (30.6 mg-kg-day DE-71 perinatally, hyperosmotic stress). Systolic blood pressure (BP), diastolic BP, and heart rate (HR) were determined using tail cuff sphygmomanometry and normalized to pretreatment values (baseline) measured under basal conditions. Hyperosmotic treatment yielded significant changes in systolic BP in PBDE exposed rats only. Hyper PBDE low and high dose rats showed 36.1 and 64.7% greater systolic BP responses at 3h post hyperosmotic injection relative to pretreatment baseline, respectively. No treatment effects were measured for diastolic BP and HR. Hyper and Hyper PBDE rats showed increased mean plasma osmolality values by 45 min after injection relative to normosmotic controls. In contrast to Hyper rats, Hyper PBDE (high) rats showed a further increase in mean plasma osmolality at 3h (358.3±12.4mOsm-L) relative to 45 min post hyperosmotic injection (325.1±11.4mOsm-L). Impaired osmoregulation in PBDE-treated animals could not be attributed to decreased levels of plasma vasopressin. Our findings suggest that developmental exposure to PBDEs may disrupt cardiovascular reactivity and osmoregulatory responses to physiological activation in late adulthoodes_ES
dc.subject.koAge Factorses_ES
dc.subject.koAnimalses_ES
dc.subject.koAnimals, Newbornes_ES
dc.subject.koBlood Pressurees_ES
dc.subject.kodrug effectses_ES
dc.subject.koDose-Response Relationship, Druges_ES
dc.subject.koFemalees_ES
dc.subject.koHalogenated Diphenyl Etherses_ES
dc.subject.koadverse effectses_ES
dc.subject.koMalees_ES
dc.subject.koOsmotic Pressurees_ES
dc.subject.kodrug effectses_ES
dc.subject.koPregnancyes_ES
dc.subject.koPrenatal Exposure Delayed Effectses_ES
dc.subject.kophysiopathologyes_ES
dc.subject.koRatses_ES
dc.subject.koRats, Long-Evanses_ES
dc.subject.koThyrotropines_ES
dc.subject.kobloodes_ES
dc.subject.koThyroxinees_ES
dc.subject.kobloodes_ES
dc.subject.koTriiodothyroninees_ES
dc.subject.kobloodes_ES
dc.subject.koVasopressinses_ES
dc.subject.kobloodes_ES
dc.subject.koWater-Electrolyte Balancees_ES
dc.subject.kodrug effectses_ES
dc.subject.koHalogenated Diphenyl Etherses_ES
dc.subject.koVasopressinses_ES
dc.subject.koTriiodothyroninees_ES
dc.subject.koThyroxinees_ES
dc.subject.koThyrotropines_ES


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