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Hesperidin produces antinociceptive response and synergistic interaction with ketorolac in an arthritic gout-type pain in rats

dc.creatorMartínez, Ana Laura
dc.creatorGonzález-Trujano, Ma. Eva
dc.creatorChávez, Marco
dc.creatorPellicer, Francisco
dc.creatorMoreno, Julia
dc.creatorLópez-Muñoz, Francisco J.
dc.date.accessioned2017-06-30T02:06:05Z
dc.date.available2017-06-30T02:06:05Z
dc.date.issued2011es_ES
dc.identifier1521es_ES
dc.identifier.issn0091-3057es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/6200
dc.identifier.urihttps://doi.org/10.1016/j.pbb.2010.11.010es_ES
dc.language.isoenges_ES
dc.relation97 (4) 683-689 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.subject.meshAnalgesics-Therapeutic usees_ES
dc.subject.meshAnimalses_ES
dc.subject.meshAnti-Inflammatory Agents, Non-Steroidal-Therapeutic usees_ES
dc.subject.meshCapsaicin-Pharmacologyes_ES
dc.subject.meshChromatography, High Pressure Liquides_ES
dc.subject.meshDose-Response Relationship, Druges_ES
dc.subject.meshDrug Synergismes_ES
dc.subject.meshGout-Drug therapyes_ES
dc.subject.meshHesperidin-Therapeutic usees_ES
dc.subject.meshKetorolac-Therapeutic usees_ES
dc.subject.meshMalees_ES
dc.subject.meshPain-Chemically inducedes_ES
dc.subject.meshPain-Drug therapyes_ES
dc.subject.meshRatses_ES
dc.subject.meshAnalgesicses_ES
dc.subject.meshAnti-Inflammatory Agents, Non-Steroidales_ES
dc.subject.meshCapsaicines_ES
dc.subject.meshHesperidines_ES
dc.subject.meshKetorolaces_ES
dc.titleHesperidin produces antinociceptive response and synergistic interaction with ketorolac in an arthritic gout-type pain in ratses_ES
dc.typearticlees_ES
dc.contributor.affiliationDirección de Investigaciones en Neurociencias, Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, Av. Mexico-Xochimilco No. 101, Col. San Lorenzo Huipulco 14370, México, D.F., Méxicoes_ES
dc.relation.jnabreviadoPHARMACOL BIOCHEM BEHAVes_ES
dc.relation.journalPharmacology Biochemistry and Behaviores_ES
dc.identifier.placeEstados Unidoses_ES
dc.date.published2011es_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñizes_ES
dc.identifier.eissn1873-5177es_ES
dc.identifier.doi10.1016/j.pbb.2010.11.010es_ES
dc.description.monthFebes_ES
dc.description.abstractotrodiomaHesperidin occurs in greatest concentration in plants from the Rutaceae and Lamiaceae families. In human nutrition it contributes to the integrity of blood vessels and its deficiency in the diet has been linked to abnormal capillary leakiness as well as pain. In this study, the bioflavonoid hesperidin was identified as an active compound in an ethanol extract of the Rosmarinus officinalis aerial parts tested in the pain-induced functional impairment model in the rat (PIFIR) as an assay of inflammatory and chronic nociception similar to that observed in clinical gout. Hesperidin produced a dose-dependent and significant response with an ED__=1666.72 mg-kg in comparison to an ED__=302.90 mg-kg for the extract or an ED__=0.47 mg-kg for the reference drug ketorolac in the PIFIR model. Although the antinociceptive response of R. officinalis was reverted in presence of the opioid antagonist naloxone (10 mg-kg, s.c.) and the 5HT(1A) antagonist WAY100635 (0.12 mg-kg, s.c.), the hesperidin response was not modified by naloxone (10 mg-kg), WAY100635 (0.12 mg-kg), bicuculline (1 mg-kg, s.c.), flumazenil (10 mg-kg, i.p.) or caffeine (1 mg-kg, s.c.). Nevertheless, it was reduced in presence of capsazepine (10 or 20 mg-kg, s.c.) suggesting the participation of the TRPV1 receptor, which was reinforced when hesperidin significantly reduced the capsaicin-induced nociceptive response. A synergistic interaction was also observed when antinociceptive doses of hesperidin were combined with those of ketorolac producing 15 combinations mainly in additive and supra-additive responses. These results provide evidence for the antinociceptive activity of hesperidin and demonstrate synergistic response when combined with ketorolac, possibly by involvement of the TRPV1 receptor, suggesting their clinical potential in pain therapyes_ES
dc.subject.kwFlavonoideses_ES
dc.subject.kwHesperidinaes_ES
dc.subject.kwKetorolacoes_ES
dc.subject.kwRosmarinus officinalis L.es_ES
dc.subject.kwSinergismoes_ES
dc.subject.koAntinociceptiones_ES
dc.subject.koFlavonoidses_ES
dc.subject.koHesperidines_ES
dc.subject.koKetorolaces_ES
dc.subject.koRosmarinus officinalis L.es_ES
dc.subject.koSynergismes_ES
dc.subject.koTRPV1 receptores_ES


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