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Long-term ovariectomy modulates the antidepressant-like action of estrogens, but not of antidepressants

dc.creatorEstrada-Camarena, Erika
dc.creatorLópez-Rubalcava, Carolina
dc.creatorHernández-Aragón, Azucena
dc.creatorMejía-Mauries, Silvia
dc.creatorPicazo, Ofir
dc.date.accessioned2017-06-30T01:41:02Z
dc.date.available2017-06-30T01:41:02Z
dc.date.issued2011es_ES
dc.identifier1518es_ES
dc.identifier.issn0269-8811es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/6197
dc.identifier.urihttps://doi.org/10.1177/0269881111408456es_ES
dc.language.isoenges_ES
dc.relation25 (10) 1365-1377 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.titleLong-term ovariectomy modulates the antidepressant-like action of estrogens, but not of antidepressantses_ES
dc.typearticlees_ES
dc.contributor.affiliationLaboratorio de Neuropsicofarmacología, Dirección de Neurociencias, Instituto Nacional de Psiquiatría 'Ramón de la Fuente Muñiz', Mexico City, Mexicoes_ES
dc.contributor.emailestrada@imp.edu.mxes_ES
dc.relation.jnabreviadoJ PSYCHOPHARMACOLes_ES
dc.relation.journalJournal of Psychopharmacologyes_ES
dc.identifier.placeEstados Unidoses_ES
dc.date.published2011es_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñizes_ES
dc.identifier.eissn1461-7285es_ES
dc.identifier.doi10.1177/0269881111408456es_ES
dc.description.monthOctes_ES
dc.description.abstractotrodiomaControversial results related to effectiveness of estrogen replacement therapy (ERT) to alleviate depression are frequently reported. The discrepancies could be related to (a) time when ERT is initiated after the beginning of menopause and-or (b) type of estrogen used. Furthermore, estrogens modulate the antidepressant effect of different compounds; therefore, the effectiveness of antidepressant drugs could also depend on the menopausal status. The aim of the present study was to analyze whether the time after estrogen decline can influence antidepressant-like effects of two estrogens and-or two antidepressants. Thus, the antidepressant-like actions of 17_-estradiol (E(2)), 17_-ethynyl-estradiol (EE(2)), fluoxetine (FLX) and desipramine (DMI) were studied at different periods (1, 3 and 12 weeks) after ovariectomy (OVX), using the forced swimming test (FST). Results showed that OVX increased depressive-like behavior only 1 week after OVX. The antidepressant-like actions of E(2), but not those of EE(2), were cancelled 12 weeks after OVX. Conversely, antidepressant-like actions of FLX and DMI were observed at 1, 3 and 12 weeks after OVX. In conclusion, while the antidepressant-like effects of estrogens depended on the time at which treatment is initiated after OVX as well as on the estrogenic compound used, antidepressant-like effects of FLX and DMI were not blocked by OVXes_ES
dc.subject.kwFactores de edades_ES
dc.subject.kwAnimaleses_ES
dc.subject.kwAgentes antidepresivoses_ES
dc.subject.kwFarmacologíaes_ES
dc.subject.kwPeso corporales_ES
dc.subject.kwDesipraminaes_ES
dc.subject.kwEstradioles_ES
dc.subject.kwEstroes_ES
dc.subject.kwFemeninoes_ES
dc.subject.kwFluoxetinaes_ES
dc.subject.kwTamaño de los Órganoses_ES
dc.subject.kwOvariectomíaes_ES
dc.subject.kwRatases_ES
dc.subject.kwRatas Wistares_ES
dc.subject.kwNataciónes_ES
dc.subject.koAge Factorses_ES
dc.subject.koAnimalses_ES
dc.subject.koAntidepressive Agentses_ES
dc.subject.kopharmacologyes_ES
dc.subject.koBody Weightes_ES
dc.subject.koDesipraminees_ES
dc.subject.koEstradioles_ES
dc.subject.koEstruses_ES
dc.subject.koFemalees_ES
dc.subject.koFluoxetinees_ES
dc.subject.koOrgan Sizees_ES
dc.subject.koOvariectomyes_ES
dc.subject.koRatses_ES
dc.subject.koRats, Wistares_ES
dc.subject.koSwimminges_ES


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