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Spasmolytic activity of Rosmarinus officinalis L. involves calcium channels in the guinea pig ileum

dc.creatorVentura-Martínez, Rosa
dc.creatorRivero-Osorno, Oscar
dc.creatorGómez, Claudia
dc.creatorGonzález-Trujano, María Eva
dc.date.accessioned2017-06-30T01:40:53Z
dc.date.available2017-06-30T01:40:53Z
dc.date.issued2011es_ES
dc.identifier1517es_ES
dc.identifier.issn0378-8741es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/6196
dc.identifier.urihttps://doi.org/10.1016/j.jep.2011.08.047es_ES
dc.language.isoenges_ES
dc.relation137 (3) 1528-1532 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.subject.meshCalcium Channel Blockers-Pharmacologyes_ES
dc.subject.meshAnimalses_ES
dc.subject.meshCalcium Channels-Drug effectses_ES
dc.subject.meshCalcium Channels-Metabolismes_ES
dc.subject.meshCholinergic Agonists-Pharmacologyes_ES
dc.subject.meshCyclooxygenase Inhibitors-Pharmacologyes_ES
dc.subject.meshDose-Response Relationship, Druges_ES
dc.subject.meshElectric Stimulationes_ES
dc.subject.meshEthanol-Chemistryes_ES
dc.subject.meshGanglionic Blockers-Pharmacologyes_ES
dc.subject.meshGuinea Pigses_ES
dc.subject.meshIleum-Drug effectses_ES
dc.subject.meshIleum-Innervationes_ES
dc.subject.meshIleum-Metabolismes_ES
dc.subject.meshMalees_ES
dc.subject.meshMuscle Relaxation-Drug effectses_ES
dc.subject.meshMuscle, Smooth-Drug effectses_ES
dc.subject.meshMuscle, Smooth-Innervationes_ES
dc.subject.meshMuscle, Smooth-Metabolismes_ES
dc.subject.meshNitric Oxide Synthase-Antagonists & inhibitorses_ES
dc.subject.meshNitric Oxide Synthase-Metabolismes_ES
dc.subject.meshParasympatholytics-Chemistryes_ES
dc.subject.meshParasympatholytics-Isolation & purificationes_ES
dc.subject.meshParasympatholytics-Pharmacologyes_ES
dc.subject.meshPlant Extracts-Chemistryes_ES
dc.subject.meshPlant Extracts-Isolation & purificationes_ES
dc.subject.meshPlant Extracts-Pharmacologyes_ES
dc.subject.meshPlants, Medicinales_ES
dc.subject.meshRosmarinus-Chemistryes_ES
dc.subject.meshSolvents-Chemistryes_ES
dc.subject.meshCalcium Channel Blockerses_ES
dc.subject.meshCalcium Channelses_ES
dc.subject.meshCholinergic Agonistses_ES
dc.subject.meshCyclooxygenase Inhibitorses_ES
dc.subject.meshGanglionic Blockerses_ES
dc.subject.meshParasympatholyticses_ES
dc.subject.meshPlant Extractses_ES
dc.subject.meshSolventses_ES
dc.subject.meshEthanoles_ES
dc.subject.meshNitric Oxide Synthasees_ES
dc.titleSpasmolytic activity of Rosmarinus officinalis L. involves calcium channels in the guinea pig ileumes_ES
dc.typearticlees_ES
dc.contributor.affiliationDepartamento de Farmacología, Facultad de Medicina, UNAM Av Universidad 3000, Ciudad Universitaria, Coyoacán, CP 04510 México, DF, Mexico.es_ES
dc.contributor.emailrventuram7@hotmail.comes_ES
dc.relation.jnabreviadoJ ETHNOPHARMACOLes_ES
dc.relation.journalJournal of Ethnopharmacologyes_ES
dc.identifier.placeIrlandaes_ES
dc.date.published2011es_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñizes_ES
dc.identifier.eissn1872-7573es_ES
dc.identifier.doi10.1016/j.jep.2011.08.047es_ES
dc.description.monthOctes_ES
dc.description.abstractotrodiomaEtnopharmacological relevance: Rosmarinus officinalis L. is a plant used around the world for its properties to cure pain in several conditions, such as arthritic and abdominal pain or as an antispasmodic; however, there are no scientific studies demonstrating its spasmolytic activity. Therefore, the aim of the present study was to investigate the effect of an ethanol extract from Rosmarinus officinalis aerial parts and the possible mechanism involved by using rings from the isolated guinea pig ileum (IGPI). Materials and methods: The IGPI rings were pre-contracted with potassium chloride (KCl; 60 mM), acetylcholine (Ach; 1 _ 10(-9) to 1 _ 10(-5)M) or electrical field stimulation (EFS; 0.3 Hz of frequency, 3.0 ms of duration and 14 V intensity) and tested in the presence of the Rosmarinus officinalis ethanol extract (150, 300, 600 and 1 200 _g-mL) or a referenced smooth muscle relaxant (papaverine, 30 _M). In addition, the possible mechanism of action was analyzed in the presence of hexametonium (a ganglionic blocker), indomethacine (an inhibitor of prostaglandins), l-NAME (a selective inhibitor of the nitric oxide synthase) and nifedipine (a calcium channel blocker). RESULTS: Rosmarinus officinalis ethanol extract exhibited a significant and concentration-dependent spasmolytic activity on the contractions induced by KCl (CI(50) = 661.06 ± 155.91 _g-mL); Ach (CI(50) = 464.05 ± 16.85 _g-mL) and EFS (CI(50) = 513.72 ± 34.13 _g-mL). Spasmolytic response of Rosmarinus officinalis (600 _g-mL) was reverted in the presence of nifedipine 1 _M, but not in the presence of hexamethonium 0.5mM, indomethacine 1 _M or L-NAME 100 _M. Conclusion: The present results reinforce the use of Rosmarinus officinalis as antispasmodic in folk medicine. Moreover, it is demonstrated the involvement of calcium channels in this activity, but not the participation of nicotinic receptors, prostaglandins or nitric oxidees_ES
dc.subject.kwCanales de calcioes_ES
dc.subject.kwMedicina tradicionales_ES
dc.subject.kwÍleon de cobayaes_ES
dc.subject.kwRosmarinus officinalis L.es_ES
dc.subject.kwEspasmolíticoes_ES
dc.subject.koCalcium channelses_ES
dc.subject.koFolk medicinees_ES
dc.subject.koGuinea-pig ileumes_ES
dc.subject.koRosmarinus officinalis L.es_ES
dc.subject.koSpasmolytices_ES


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