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Anti-ulcer activity of Cyrtocarpa procera analogous to that of Amphipterygium adstringens, both assayed on the experimental gastric injury in rats
dc.creator | Rosas-Acevedo, Hortensia | |
dc.creator | Terrazas, Teresa | |
dc.creator | González-Trujano, M. Eva | |
dc.creator | Guzmán, Yolanda | |
dc.creator | Soto-Hernández, Marcos | |
dc.date.accessioned | 2017-06-30T01:40:43Z | |
dc.date.available | 2017-06-30T01:40:43Z | |
dc.date.issued | 2011 | es_ES |
dc.identifier | 1516 | es_ES |
dc.identifier.issn | 0378-8741 | es_ES |
dc.identifier.uri | http://repositorio.inprf.gob.mx/handle/123456789/6195 | |
dc.identifier.uri | https://doi.org/10.1016/j.jep.2010.11.057 | es_ES |
dc.language.iso | eng | es_ES |
dc.relation | 134 (1) 67-73 p. | es_ES |
dc.relation | versión del editor | es_ES |
dc.rights | acceso cerrado | es_ES |
dc.title | Anti-ulcer activity of Cyrtocarpa procera analogous to that of Amphipterygium adstringens, both assayed on the experimental gastric injury in rats | es_ES |
dc.type | article | es_ES |
dc.contributor.affiliation | Facultad de Estudios Superiores "Zaragoza", Universidad Nacional Autónoma de México, J.C. Bonilla 66 y Calzada Ignacio Zaragoza, Col. Ejército de Oriente, Iztapalapa 09230, México, D.F., Mexico. | es_ES |
dc.contributor.email | evag@imp.edu.mx | es_ES |
dc.relation.jnabreviado | J ETHNOPHARMACOL | es_ES |
dc.relation.journal | Journal of Ethnopharmacology | es_ES |
dc.identifier.place | Irlanda | es_ES |
dc.date.published | 2011 | es_ES |
dc.identifier.organizacion | Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz | es_ES |
dc.identifier.eissn | 1872-7573 | es_ES |
dc.identifier.doi | 10.1016/j.jep.2010.11.057 | es_ES |
dc.description.month | Mar | es_ES |
dc.description.abstractotrodioma | ETHNOPHARMACOLOGICAL RELEVANCE: The bark of Amphipterygium adstringens (Aa) is commonly mixed or adulterated with the bark of Cyrtocarpa procera (Cp) and sold in Mexican markets. Aa is a well known species in Mexico used as decoction to relieve ulcers. Scientific reports reinforcing the anti-ulcer activity of Aa have been previously described, but those describing the anti-ulcer properties of Cp as a substitute for Aa in folk medicine are scarce. AIM OF THE STUDY: To investigate anatomical and phytochemical differences between these species, as well as to assess the anti-ulcer effect of Cp extracts in comparison to the Aa extracts. MATERIAL AND METHODS: Anatomical micro-technique and physical and spectroscopic data were used to analyze differences between Cp and Aa. Regard to the pharmacological activity, it was assessed by using the ethanol-induced gastric damage model in rats. RESULTS: Whereas the bark anatomy of Aa was characterized by vertical canals in the periderm and the rare occurrence of fibers in its phloem, a periderm without vertical canals and abundant fibers in the phloem were distinctive features of Cp. Phytochemical analysis allowed the identification of tirucallane, masticadienonic and 3_-hydroxymasticadienonic acids as major components in Aa, while _-amyrin and _-sitosterol were obtained from Cp. Gastric lesions observed in the control group decreased in the presence of 100mg-kg of hexane, ethyl acetate and methanol extracts from the normal or regenerated bark of Cp, thus resembling the anti-ulcer effect of Aa. Nevertheless, major anti-ulcer potency was observed with the most active methanol extract from Cp obtained from normal [the effective dose fifty ED(50)=45.54 mg-kg] or regenerated (ED(50)=36.68 mg-kg) bark in comparison to Aa (ED(50)=115.64 mg-kg). CONCLUSION: Chemical and anatomical differences were found between these species, but since the anti-ulcer activity of Cp is similar to that shown by Aa our results reinforce the use of both species for the relief of gastric ulcer in folk medicine | es_ES |
dc.subject.ko | Anacardiaceae | es_ES |
dc.subject.ko | chemistry | es_ES |
dc.subject.ko | Animals | es_ES |
dc.subject.ko | Anti-Ulcer Agents | es_ES |
dc.subject.ko | pharmacology | es_ES |
dc.subject.ko | Anti-Ulcer Agents | es_ES |
dc.subject.ko | therapeutic use | es_ES |
dc.subject.ko | Gastric Mucosa | es_ES |
dc.subject.ko | drug effects | es_ES |
dc.subject.ko | Plant Extracts | es_ES |
dc.subject.ko | pharmacology | es_ES |
dc.subject.ko | Plant Extracts | es_ES |
dc.subject.ko | therapeutic use | es_ES |
dc.subject.ko | Rats | es_ES |
dc.subject.ko | Anti-Ulcer Agents | es_ES |
dc.subject.ko | Plant Extracts | es_ES |
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