Mostrar el registro sencillo del ítem

Sex steroids effects on the molting process of the helminth human parasite Trichinella spiralis

dc.creatorHernández-Bello, Romel
dc.creatorRamírez-Nieto Ricardo
dc.creatorMuñiz-Hernández, Saé
dc.creatorNava-Castro, Karen
dc.creatorPavón, Lenin
dc.creatorSánchez-Acosta, Ana Gabriela
dc.creatorMorales-Montor, Jorge
dc.date.accessioned2017-06-30T01:40:26Z
dc.date.available2017-06-30T01:40:26Z
dc.date.issued2011es_ES
dc.identifier1514es_ES
dc.identifier.issn1110-7251es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/6193
dc.identifier.urihttps://doi.org/10.1155/2011/625380es_ES
dc.language.isoenges_ES
dc.relation1-10 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.titleSex steroids effects on the molting process of the helminth human parasite Trichinella spiralises_ES
dc.typearticlees_ES
dc.contributor.affiliationDepartamento de Inmunología, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, 04510 México, DF, Mexicoes_ES
dc.contributor.emailjmontor66@biomedicas.unam.mxes_ES
dc.relation.jnabreviadoJ BIOMED BIOTECHNOLes_ES
dc.relation.journalJournal of Biomedicine and Biotechnologyes_ES
dc.identifier.placeEstados Unidoses_ES
dc.date.published2011es_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñizes_ES
dc.identifier.eissn1110-7243es_ES
dc.identifier.doi10.1155/2011/625380es_ES
dc.description.abstractotrodiomaWe evaluated the in vitro effects of estradiol, progesterone, and testosterone on the molting process, which is the initial and crucial step in the development of the muscular larvae (ML or L1) to adult worm. Testosterone had no significative effect on the molting rate of the parasite, however, progesterone decreased the molting rate about a 50% in a concentration- and time-independent pattern, while estradiol had a slight effect (10%). The gene expression of caveolin-1, a specific gene used as a marker of parasite development, showed that progesterone and estradiol downregulated its expression, while protein expression was unaffected. By using flow citometry, a possible protein that is recognized by a commercial antiprogesterone receptor antibody was detected. These findings may have strong implications in the host-parasite coevolution, in the sex-associated susceptibility to this infection and could point out to possibilities to use antihormones to inhibit parasite developmentes_ES
dc.subject.koAnimalses_ES
dc.subject.koCaveolin 1es_ES
dc.subject.kodrug effectses_ES
dc.subject.koCaveolin 1es_ES
dc.subject.kometabolismes_ES
dc.subject.koDown-Regulationes_ES
dc.subject.kodrug effectses_ES
dc.subject.koEstradioles_ES
dc.subject.kometabolismes_ES
dc.subject.koEstradioles_ES
dc.subject.kopharmacologyes_ES
dc.subject.koFemalees_ES
dc.subject.koGene Expressiones_ES
dc.subject.kodrug effectses_ES
dc.subject.koGene Expressiones_ES
dc.subject.kophysiologyes_ES
dc.subject.koGonadal Steroid Hormoneses_ES
dc.subject.kometabolismes_ES
dc.subject.koGonadal Steroid Hormoneses_ES
dc.subject.kopharmacologyes_ES
dc.subject.koHelminthiasises_ES
dc.subject.kodrug therapyes_ES
dc.subject.koHelminthiasises_ES
dc.subject.koparasitologyes_ES
dc.subject.koHost-Parasite Interactionses_ES
dc.subject.kophysiologyes_ES
dc.subject.koHumanses_ES
dc.subject.koLarvaes_ES
dc.subject.kodrug effectses_ES
dc.subject.koLarvaes_ES
dc.subject.kogrowth & developmentes_ES
dc.subject.koMoltinges_ES
dc.subject.kodrug effectses_ES
dc.subject.koMoltinges_ES
dc.subject.kophysiologyes_ES
dc.subject.koProgesteronees_ES
dc.subject.kometabolismes_ES
dc.subject.koProgesteronees_ES
dc.subject.kopharmacologyes_ES
dc.subject.koReceptors, Progesteronees_ES
dc.subject.kodrug effectses_ES
dc.subject.koReceptors, Progesteronees_ES
dc.subject.kometabolismes_ES
dc.subject.koTestosteronees_ES
dc.subject.kometabolismes_ES
dc.subject.koTestosteronees_ES
dc.subject.kopharmacologyes_ES
dc.subject.koTrichinella spiralises_ES
dc.subject.kodrug effectses_ES
dc.subject.koTrichinella spiralises_ES
dc.subject.kogrowth & developmentes_ES
dc.subject.koCaveolin 1es_ES
dc.subject.koGonadal Steroid Hormoneses_ES
dc.subject.koReceptors, Progesteronees_ES
dc.subject.koEstradioles_ES
dc.subject.koProgesteronees_ES
dc.subject.koTestosteronees_ES


Ficheros en el ítem

FicherosTamañoFormatoVer

No hay ficheros asociados a este ítem.

Este ítem aparece en la(s) siguiente(s) colección(ones)

Mostrar el registro sencillo del ítem