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Functional magnetic resonance imaging response to experimental pain in drug-free patients with schizophrenia

dc.creatorDe la Fuente-Sandoval, Camilo
dc.creatorFavila, Rafael
dc.creatorGómez-Martín, Diana
dc.creatorPellicer, Francisco
dc.creatorGraff-Guerrero, Ariel
dc.date.accessioned2017-06-30T01:39:35Z
dc.date.available2017-06-30T01:39:35Z
dc.date.issued2010es_ES
dc.identifier1507es_ES
dc.identifier.issn0165-1781es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/6186
dc.identifier.urihttps://doi.org/10.1016/j.pscychresns.2010.05.003es_ES
dc.language.isoenges_ES
dc.relation183 (2) 99-104 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.titleFunctional magnetic resonance imaging response to experimental pain in drug-free patients with schizophreniaes_ES
dc.typearticlees_ES
dc.contributor.affiliationLaboratorio de Psiquiatría Experimental, Instituto Nacional de Neurología y Neurocirugía, Mexico City, Mexico.es_ES
dc.relation.jnabreviadoPSYCHIATRY RESes_ES
dc.relation.journalPsychiatry Research: Neuroimaginges_ES
dc.identifier.placeIrlandaes_ES
dc.date.published2010es_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñizes_ES
dc.identifier.eissn1872-7123es_ES
dc.identifier.doihttp://dx.doi.org/10.1016/j.pscychresns.2010.05.003es_ES
dc.description.monthAgoes_ES
dc.description.abstractotrodiomaClinical evidence suggests that there is decreased pain sensitivity in schizophrenia; however, the neurobiological mechanism of this decrease remains unknown. Using functional magnetic resonance imaging, we examined the blood oxygen level-dependent (BOLD) changes induced by experimental pain-tolerance (endure) hot stimuli vs. non-painful stimuli during an acute psychotic episode in 12 drug-free patients with schizophrenia and in 13 gender- and age-matched healthy controls. The analyses revealed that patients showed a greater BOLD response at S1 compared with controls but a reduced BOLD response in the posterior cingulate cortex (PCC), insula, and brainstem during pain-tolerance stimuli. Pain-tolerance temperature was higher in patients than in healthy controls. BOLD response in the insula positively correlated with unpleasantness and temperature in controls, but this effect was not observed in patients. S1 BOLD response positively correlated with unpleasantness in patients but not in controls. These initial results confirm that unmedicated patients with schizophrenia have a higher pain tolerance than controls, decreased activation in pain affective-cognitive processing regions (insula, PCC, brainstem), and an over-activation of the primary sensory-discriminative pain processing region (S1). These pilot results are the first to explore the mechanism driving altered pain sensitivity in schizophreniaes_ES
dc.subject.koAdultes_ES
dc.subject.koBraines_ES
dc.subject.koblood supplyes_ES
dc.subject.koBraines_ES
dc.subject.kophysiopathologyes_ES
dc.subject.koBrain Mappinges_ES
dc.subject.koCase-Control Studieses_ES
dc.subject.koChi-Square Distributiones_ES
dc.subject.koFemalees_ES
dc.subject.koFunctional Lateralityes_ES
dc.subject.koHot Temperaturees_ES
dc.subject.koadverse effectses_ES
dc.subject.koHumanses_ES
dc.subject.koImage Processing, Computer-Assistedes_ES
dc.subject.komethodses_ES
dc.subject.koMagnetic Resonance Imaginges_ES
dc.subject.koMalees_ES
dc.subject.koOxygenes_ES
dc.subject.kobloodes_ES
dc.subject.koPaines_ES
dc.subject.koetiologyes_ES
dc.subject.koPaines_ES
dc.subject.kopathologyes_ES
dc.subject.koPain Thresholdes_ES
dc.subject.kophysiologyes_ES
dc.subject.koRetrospective Studieses_ES
dc.subject.koSchizophreniaes_ES
dc.subject.kophysiopathologyes_ES
dc.subject.koSchizophrenic Psychologyes_ES
dc.subject.koYoung Adultes_ES


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