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Tramadol and caffeine produce synergistic interactions on antinociception measured in a formalin model

dc.creatorDíaz-Reval, M. Irene
dc.creatorCarrillo-Munguía, Norma
dc.creatorMartínez-Casas, Maribel
dc.creatorGonzález-Trujano, M. Eva
dc.date.accessioned2017-06-30T01:39:18Z
dc.date.available2017-06-30T01:39:18Z
dc.date.issued2010es_ES
dc.identifier1505es_ES
dc.identifier.issn0091-3057es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/6184
dc.identifier.urihttps://doi.org/10.1016/j.pbb.2010.09.004es_ES
dc.language.isoenges_ES
dc.relation97 (2) 357-362 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.titleTramadol and caffeine produce synergistic interactions on antinociception measured in a formalin modeles_ES
dc.typearticlees_ES
dc.contributor.affiliationCentro Universitario de Investigaciones Biomédicas, Universidad de Colima, Av. 25 de Julio No. 965, Col. Villa San Sebastian, Colima, Col. México, C.P. 28045, Mexico.es_ES
dc.contributor.emailidiazre@ucol.mxes_ES
dc.relation.jnabreviadoPHARMACOL BIOCHEM BEHAVes_ES
dc.relation.journalPharmacology Biochemistry and Behaviores_ES
dc.identifier.placeEstados Unidoses_ES
dc.date.published2010es_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñizes_ES
dc.identifier.eissn1873-5177es_ES
dc.identifier.doi10.1016/j.pbb.2010.09.004es_ES
dc.description.monthDices_ES
dc.description.abstractotrodiomaDrug combinations have been used in clinical practice for the main purpose of increasing therapeutic effect efficacy. The aim of this study was to determine the antinociceptive effect of tramadol and caffeine administered separately or in combination, as well as their synergistic interaction. The formalin test was used. Nociceptive behavior was evaluated by flinching response of the formalin-treated paw. Rats were divided into five groups and received tramadol alone (4.9-49.6mg/kg, s.c.), caffeine alone (1-17.8mg/kg, p.o.), or combinations of tramadol (4.9, 8.8, 15.6 and 20.8mg/kg, s.c.) and caffeine (1, 3.16 and 10mg/kg, p.o.). Tramadol showed dose-dependent antinociceptive effect in both phases of the formalin test. Caffeine only presented antinociceptive effect in the second phase and this effect was also dose-dependent. In Phase 1, combinations of tramadol and caffeine showed antinociceptive effect similar to that of tramadol alone. In Phase 2, the dose-response curve shifted to the left with the combination of tramadol and each dose of caffeine. Synergism analysis resulted in synergistic effect in ten combinations and antagonism in two combinations. In conclusion, the synergism observed in the majority of tramadol and caffeine combinations used in this study suggests that this drug combination is useful in the treatment of paines_ES
dc.subject.koAnalgesics, Opioides_ES
dc.subject.kopharmacologyes_ES
dc.subject.koAnimalses_ES
dc.subject.koCaffeinees_ES
dc.subject.kopharmacologyes_ES
dc.subject.koCentral Nervous System Stimulantses_ES
dc.subject.kopharmacologyes_ES
dc.subject.koData Interpretation, Statisticales_ES
dc.subject.koDose-Response Relationship, Druges_ES
dc.subject.koDrug Synergismes_ES
dc.subject.koFormaldehydees_ES
dc.subject.kodiagnostic usees_ES
dc.subject.koMalees_ES
dc.subject.koPain Measurementes_ES
dc.subject.kodrug effectses_ES
dc.subject.koRatses_ES
dc.subject.koRats, Wistares_ES
dc.subject.koTramadoles_ES
dc.subject.kopharmacologyes_ES
dc.subject.koAnalgesics, Opioides_ES
dc.subject.koCentral Nervous System Stimulantses_ES
dc.subject.koTramadoles_ES
dc.subject.koFormaldehydees_ES
dc.subject.koCaffeinees_ES


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