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Anticonvulsive effect of vitamin C on pentylenetetrazol-induced seizures in immature rats

dc.creatorGonzález-Ramírez, Misael
dc.creatorRazo-Juárez, León I.
dc.creatorSauer-Ramírez, José L.
dc.creatorGonzález-Trujano, M. Eva
dc.creatorSalgado-Ceballos, Hermelinda
dc.creatorOrozco-Suarez, Sandra
dc.date.accessioned2017-06-30T01:39:10Z
dc.date.available2017-06-30T01:39:10Z
dc.date.issued2010es_ES
dc.identifier1504es_ES
dc.identifier.issn0091-3057es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/6183
dc.identifier.urihttps://doi.org/10.1016/j.pbb.2010.08.009es_ES
dc.language.isoenges_ES
dc.relation97 (2) 267-272 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.titleAnticonvulsive effect of vitamin C on pentylenetetrazol-induced seizures in immature ratses_ES
dc.typearticlees_ES
dc.contributor.affiliationUnidad de Investigación Médica en Enfermedades Neurológicas, Hospital de Especialidades. Centro Médico Nacional Siglo XXI. IMSS. Av. Cuauhtemoc 330 Col Doctores. México, D.F. Mexicoes_ES
dc.contributor.emailmgonzalezr@cis.gob.mxes_ES
dc.relation.jnabreviadoPHARMACOL BIOCHEM BEHAVes_ES
dc.relation.journalPharmacology Biochemistry and Behaviores_ES
dc.identifier.placeEstados Unidoses_ES
dc.date.published2010es_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñizes_ES
dc.identifier.eissn1873-5177es_ES
dc.identifier.doi10.1016/j.pbb.2010.08.009es_ES
dc.description.monthDices_ES
dc.description.abstractotrodiomaVitamin C helps to prevent brain oxidative stress and participate in the synthesis of progesterone. It also possesses a progesterone-like effect and acts synergistically with progesterone on the brain. Progesterone and its metabolites, but also vitamin C have been associated with anticonvulsant effects. We evaluated the progesterone concentration 30min and 24h after the last administration of vitamin C (500mg/kg, i.p. for five days). We also evaluated how vitamin C altered pentylenetetrazol (PTZ)-induced seizures by measuring the onset latency of seizures, percentage of incidence and mortality as well as amino acid levels after seizures. Vitamin C treatment alone increased basal progesterone concentrations to 531% after 30min compared to 253% after 24h. Furthermore, vitamin C significantly increased the latency to the first myoclonic, clonic and tonic seizure induced by PTZ (80mg/kg, i.p.) and decreased the percentage of incidence of clonic and tonic seizures as well as the mortality rate. Changes in tissue concentration of amino acids were primarily observed at 24h after vitamin C treatment. Our results suggest that vitamin C together with progesterone and/or its metabolites are involved in the protection against PTZ-induced seizures in immature ratses_ES
dc.subject.koAnimalses_ES
dc.subject.koAnticonvulsantses_ES
dc.subject.koAscorbic Acides_ES
dc.subject.kopharmacologyes_ES
dc.subject.koAspartic Acides_ES
dc.subject.kometabolismes_ES
dc.subject.koBrain Chemistryes_ES
dc.subject.kodrug effectses_ES
dc.subject.koChromatography, High Pressure Liquides_ES
dc.subject.koConvulsantses_ES
dc.subject.koantagonists & inhibitorses_ES
dc.subject.koDose-Response Relationship, Druges_ES
dc.subject.koEpilepsies, Myoclonices_ES
dc.subject.kochemically inducedes_ES
dc.subject.koEpilepsies, Myoclonices_ES
dc.subject.koprevention & controles_ES
dc.subject.koEpilepsy, Tonic-Clonices_ES
dc.subject.kochemically inducedes_ES
dc.subject.koEpilepsy, Tonic-Clonices_ES
dc.subject.koprevention & controles_ES
dc.subject.koFemalees_ES
dc.subject.koGlutamateses_ES
dc.subject.kometabolismes_ES
dc.subject.koGlutaminees_ES
dc.subject.kometabolismes_ES
dc.subject.koMalees_ES
dc.subject.koPentylenetetrazolees_ES
dc.subject.koantagonists & inhibitorses_ES
dc.subject.koProgesteronees_ES
dc.subject.kometabolismes_ES
dc.subject.koRatses_ES
dc.subject.koRats, Sprague-Dawleyes_ES
dc.subject.koSeizureses_ES
dc.subject.kochemically inducedes_ES
dc.subject.koSeizureses_ES
dc.subject.kometabolismes_ES
dc.subject.koSeizureses_ES
dc.subject.koprevention & controles_ES
dc.subject.koVitaminses_ES
dc.subject.kopharmacologyes_ES
dc.subject.kogamma-Aminobutyric Acides_ES
dc.subject.kometabolismes_ES
dc.subject.koAnticonvulsantses_ES
dc.subject.koConvulsantses_ES
dc.subject.koGlutamateses_ES
dc.subject.koVitaminses_ES
dc.subject.koAscorbic Acides_ES
dc.subject.koPentylenetetrazolees_ES
dc.subject.kogamma-Aminobutyric Acides_ES
dc.subject.koAspartic Acides_ES
dc.subject.koGlutaminees_ES
dc.subject.koProgesteronees_ES


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