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HPLC/MS analysis and anxiolytic-like effect of quercetin and kaempferol flavonoids from Tilia americana var. Mexicana

dc.creatorAguirre-Hernández, Eva
dc.creatorGonzález-Trujano, Ma. Eva
dc.creatorMartínez, Ana Laura
dc.creatorMoreno, Julia
dc.creatorKite, Geoffrey
dc.creatorTerrazas, Teresa
dc.creatorSoto-Hernández, Marcos
dc.date.accessioned2017-06-30T01:38:31Z
dc.date.available2017-06-30T01:38:31Z
dc.date.issued2010es_ES
dc.identifier1497es_ES
dc.identifier.issn0378-8741es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/6178
dc.identifier.urihttps://doi.org/10.1016/j.jep.2009.09.044es_ES
dc.language.isoenges_ES
dc.relation127 (1) 91-97 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.subject.meshAnimalses_ES
dc.subject.meshAnti-Anxiety Agents-Pharmacologyes_ES
dc.subject.meshChromatography, High Pressure Liquides_ES
dc.subject.meshDose-Response Relationship, Druges_ES
dc.subject.meshGlycosides-Analysises_ES
dc.subject.meshGlycosides-Pharmacologyes_ES
dc.subject.meshHypnosis, Anesthetices_ES
dc.subject.meshHypnotics and Sedatives-Analysises_ES
dc.subject.meshHypnotics and Sedatives-Pharmacologyes_ES
dc.subject.meshInflorescence-Chemistryes_ES
dc.subject.meshKaempferols-Analysises_ES
dc.subject.meshKaempferols-Pharmacologyes_ES
dc.subject.meshLocomotion-Drug effectses_ES
dc.subject.meshMalees_ES
dc.subject.meshMaze Learning-Drug effectses_ES
dc.subject.meshMedicine, Traditionales_ES
dc.subject.meshMexicoes_ES
dc.subject.meshMicees_ES
dc.subject.meshPentobarbital-Pharmacologyes_ES
dc.subject.meshPhytotherapyes_ES
dc.subject.meshPlant Extracts-Chemistryes_ES
dc.subject.meshPlant Extracts-Pharmacologyes_ES
dc.subject.meshQuercetin-Analogs & derivativeses_ES
dc.subject.meshQuercetin-Analysises_ES
dc.subject.meshQuercetin-Pharmacologyes_ES
dc.subject.meshReaction Time-Drug effectses_ES
dc.subject.meshSpecies Specificityes_ES
dc.subject.meshTandem Mass Spectrometryes_ES
dc.subject.meshAnti-Anxiety Agentses_ES
dc.subject.meshTilia-Chemistryes_ES
dc.subject.meshGlycosideses_ES
dc.subject.meshHypnotics and Sedativeses_ES
dc.subject.meshKaempferolses_ES
dc.subject.meshPlant Extractses_ES
dc.subject.meshQuercetines_ES
dc.subject.meshPentobarbitales_ES
dc.subject.meshAnti-Anxiety Agents-Analysises_ES
dc.subject.meshDrug Synergismes_ES
dc.titleHPLC/MS analysis and anxiolytic-like effect of quercetin and kaempferol flavonoids from Tilia americana var. Mexicanaes_ES
dc.typearticlees_ES
dc.contributor.affiliationDirección de Investigaciones en Neurociencias, Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, Calz México-Xochimilco 101, Col San Lorenzo Huipulco, 14370 México, DF, Mexicoes_ES
dc.contributor.emailevag@imp.edu.mxes_ES
dc.relation.jnabreviadoJ ETHNOPHARMACOLes_ES
dc.relation.journalJournal of Ethnopharmacologyes_ES
dc.identifier.placeIrlandaes_ES
dc.date.published2010es_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñizes_ES
dc.identifier.eissn1872-7573es_ES
dc.identifier.doi10.1016/j.jep.2009.09.044es_ES
dc.description.monthEnees_ES
dc.description.abstractotrodiomaAIM OF THE STUDY: Around the world, Tilia species have been used in traditional medicine for their properties as tranquilizer. Furthermore, Mexican species of Tilia have been grouped as Tilia americana var. mexicana, but their specific content in flavonoids is poorly described. In this study, inflorescences of Mexican Tilia were collected in three different regions of Mexico to compare their flavonoid content and anxiolytic-like response. MATERIALS AND METHODS: Flavonoid content was analyzed by using an HPLC-MS technique. For anxiolytic-like response, Tilia inflorescences extracts (from 10 to 300 mg/kg, i.p.) were tested in experimental models (open-field, hole-board and plus-maze tests, as well as sodium pentobarbital-induced hypnosis) in mice. RESULTS: HPLC-MS analysis revealed specific peaks of flavonoid composition demonstrating some differences in these compounds in flowers and bracts depending on the region of collection. No differences in the neuropharmacological activity among these samples of Tilia were found. Moreover, their effects were associated with quercetin and kaempferol glycosides. CONCLUSIONS: Dissimilarities in the flavonoid composition of Mexican Tilias might imply that these species must be re-classified in more than one species, not as a unique Tilia americana var. mexicana. Since quercetin and kaempferol aglycons demonstrated anxiolytic-like response and that no difference in the pharmacological evaluation was observed between these three Mexican Tilias, we suggest that this pharmacological effect of Tilia inflorescences involves these flavonoids occurrence independently of the kind of glycosides present in the samples reinforcing their use in traditional medicine in several regions of Mexico.es_ES
dc.subject.kwAnsiedades_ES
dc.subject.kwAnsiolíticoses_ES
dc.subject.kwSistema nervioso centrales_ES
dc.subject.kwKaempferoles_ES
dc.subject.kwQuercetinaes_ES
dc.subject.kwTilia americana var. mexicanaes_ES
dc.subject.kwTiliaceaees_ES
dc.subject.koAnxietyes_ES
dc.subject.koAnxiolytices_ES
dc.subject.koCentral nervous systemes_ES
dc.subject.koKaempferoles_ES
dc.subject.koQuercetines_ES
dc.subject.koTilia americana var. mexicanaes_ES
dc.subject.koTiliaceaees_ES


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