Mostrar el registro sencillo del ítem

Distribution of hypophysiotropic thyrotropin-releasing hormone (TRH)-synthesizing neurons in the hypothalamic paraventricular nucleus of the mouse

dc.creatorKádár, Andrea
dc.creatorSánchez, Edith
dc.creatorWittmann, Gábor
dc.creatorSingru, Praful S.
dc.creatorFüzesi, Tamás
dc.creatorMarsili, Alessandro
dc.creatorLarsen, P. Reed
dc.creatorLiposits, Zsolt
dc.creatorLechan, Ronald M.
dc.creatorFekete, Csaba
dc.date.accessioned2017-06-30T01:38:14Z
dc.date.available2017-06-30T01:38:14Z
dc.date.issued2010es_ES
dc.identifier1495es_ES
dc.identifier.issn0021-9967es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/6176
dc.identifier.urihttps://doi.org/10.1002/cne.22432es_ES
dc.language.isoenges_ES
dc.relation518 (19) 3948-3961 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.titleDistribution of hypophysiotropic thyrotropin-releasing hormone (TRH)-synthesizing neurons in the hypothalamic paraventricular nucleus of the mousees_ES
dc.typearticlees_ES
dc.contributor.affiliationDepartment of Endocrine Neurobiology, Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, Hungary 1083es_ES
dc.relation.jnabreviadoJ COMP NEUROLes_ES
dc.relation.journalThe Journal of Comparative Neurologyes_ES
dc.identifier.placeEstados Unidoses_ES
dc.date.published2010es_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñizes_ES
dc.identifier.eissn1096-9861es_ES
dc.identifier.doi10.1002/cne.22432es_ES
dc.description.monthOctes_ES
dc.description.abstractotrodiomaHypophysiotropic thyrotropin-releasing hormone (TRH) neurons, the central regulators of the hypothalamic-pituitary-thyroid axis, are located in the hypothalamic paraventricular nucleus (PVN) in a partly overlapping distribution with non-hypophysiotropic TRH neurons. The distribution of hypophysiotropic TRH neurons in the rat PVN is well understood, but the localization of these neurons is unknown in mice. To determine the distribution and phenotype of hypophysiotropic TRH neurons in mice, double- and triple-labeling experiments were performed on sections of intact mice, and mice treated intravenously and intraperitoneally with the retrograde tracer Fluoro-Gold. TRH neurons were located in all parts of the PVN except the periventricular zone. Hypophysiotropic TRH neurons were observed only at the mid-level of the PVN, primarily in the compact part. In this part of the PVN, TRH neurons were intermingled with oxytocin and vasopressin neurons, but based on their size, the TRH neurons were parvocellular and did not contain magnocellular neuropeptides. Co-localization of TRH and cocaine- and amphetamine-regulated transcript (CART) were observed only in areas where hypophysiotropic TRH neurons were located. In accordance with the morphological observations, hypothyroidism increased TRH mRNA content of neurons only at the mid-level of the PVN. These data demonstrate that the distribution of hypophysiotropic TRH neurons in mice is vastly different from the pattern in rats, with a dominant occurrence of these neurosecretory cells in the compact part and adjacent regions at the mid-level of the PVN. Furthermore, our data demonstrate that the organization of the PVN is markedly different in mice and ratses_ES
dc.subject.koAnimalses_ES
dc.subject.koHypothyroidismes_ES
dc.subject.koImmunohistochemistryes_ES
dc.subject.koMalees_ES
dc.subject.koMicees_ES
dc.subject.koMice, Inbred C57BLes_ES
dc.subject.koNeuronses_ES
dc.subject.kocytologyes_ES
dc.subject.koNeuronses_ES
dc.subject.kometabolismes_ES
dc.subject.koOxytocines_ES
dc.subject.kometabolismes_ES
dc.subject.koParaventricular Hypothalamic Nucleuses_ES
dc.subject.kocytologyes_ES
dc.subject.koParaventricular Hypothalamic Nucleuses_ES
dc.subject.kometabolismes_ES
dc.subject.koRatses_ES
dc.subject.koThyrotropin-Releasing Hormonees_ES
dc.subject.kometabolismes_ES
dc.subject.koVasopressinses_ES
dc.subject.kometabolismes_ES
dc.subject.koVasopressinses_ES
dc.subject.koThyrotropin-Releasing Hormonees_ES
dc.subject.koOxytocines_ES


Ficheros en el ítem

FicherosTamañoFormatoVer

No hay ficheros asociados a este ítem.

Este ítem aparece en la(s) siguiente(s) colección(ones)

Mostrar el registro sencillo del ítem