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Evaluation of the effect of selective serotonin-reuptake inhibitors on lymphocyte subsets in patients with a major depressive disorder

dc.creatorHernández, María Eugenia
dc.creatorMartínez-Fong, Daniel
dc.creatorPérez-Tapia, Mayra
dc.creatorEstrada-García, Iris
dc.creatorEstrada-Parra, Sergio
dc.creatorPavón, Lenin
dc.date.accessioned2017-06-30T01:37:57Z
dc.date.available2017-06-30T01:37:57Z
dc.date.issued2010es_ES
dc.identifier1493es_ES
dc.identifier.issn0924-977Xes_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/6174
dc.identifier.urihttps://doi.org/10.1016/j.euroneuro.2009.11.005es_ES
dc.language.isoenges_ES
dc.relation20 (2) 88-95 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.titleEvaluation of the effect of selective serotonin-reuptake inhibitors on lymphocyte subsets in patients with a major depressive disorderes_ES
dc.typearticlees_ES
dc.contributor.affiliationDepartment of Psychoimmunology, National Institute of Psychiatry Ramón de la Fuente, Mexico.es_ES
dc.relation.jnabreviadoEUR NEUROPSYCHOPHARMACOLes_ES
dc.relation.journalEuropean Neuropsychopharmacologyes_ES
dc.identifier.placePaíses Bajoses_ES
dc.date.published2010es_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñizes_ES
dc.identifier.eissn1873-7862es_ES
dc.identifier.doi10.1016/j.euroneuro.2009.11.005es_ES
dc.description.monthFebes_ES
dc.description.abstractotrodiomaTo date, only the effect of a short-term antidepressant treatment (<12 weeks) on neuroendocrinoimmune alterations in patients with a major depressive disorder has been evaluated. Our objective was to determine the effect of a 52-week long treatment with selective serotonin-reuptake inhibitors on lymphocyte subsets. The participants were thirty-one patients and twenty-two healthy volunteers. The final number of patients (10) resulted from selection and course, as detailed in the enrollment scheme. Methods used to psychiatrically analyze the participants included the Mini-International Neuropsychiatric Interview, Hamilton Depression Scale and Beck Depression Inventory. The peripheral lymphocyte subsets were measured in peripheral blood using flow cytometry. Before treatment, increased counts of natural killer (NK) cells in patients were statistically significant when compared with those of healthy volunteers (312+/-29 versus 158+/-30; cells/mL), but no differences in the populations of T and B cells were found. The patients showed remission of depressive episodes after 20 weeks of treatment along with an increase in NK cell and B cell populations, which remained increased until the end of the study. At the 52nd week of treatment, patients showed an increase in the counts of NK cells (396+/-101 cells/mL) and B cells (268+/-64 cells/mL) compared to healthy volunteers (NK, 159+/-30 cells/mL; B cells, 179+/-37 cells/mL). We conclude that long-term treatment with selective serotonin-reuptake inhibitors not only causes remission of depressive symptoms, but also affects lymphocyte subset populations. The physiopathological consequence of these changes remains to be determinedes_ES
dc.subject.koAdultes_ES
dc.subject.koB-Lymphocyteses_ES
dc.subject.kodrug effectses_ES
dc.subject.koDepressive Disorder, Majores_ES
dc.subject.kodrug therapyes_ES
dc.subject.koDepressive Disorder, Majores_ES
dc.subject.koimmunologyes_ES
dc.subject.koFemalees_ES
dc.subject.koHumanses_ES
dc.subject.koKiller Cells, Naturales_ES
dc.subject.kodrug effectses_ES
dc.subject.koLymphocyte Subsetses_ES
dc.subject.kodrug effectses_ES
dc.subject.koMalees_ES
dc.subject.koSerotonin Uptake Inhibitorses_ES
dc.subject.kopharmacologyes_ES
dc.subject.koSerotonin Uptake Inhibitorses_ES
dc.subject.kotherapeutic usees_ES
dc.subject.koT-Lymphocyteses_ES
dc.subject.kodrug effectses_ES
dc.subject.koSerotonin Uptake Inhibitorses_ES


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