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Aging impairs the antidepressant-like response to citalopram in male rats

dc.creatorHerrera-Pérez, José Jaime
dc.creatorMartínez-Mota, Lucía
dc.creatorFernández-Guasti, Alonso
dc.date.accessioned2017-06-30T01:37:48Z
dc.date.available2017-06-30T01:37:48Z
dc.date.issued2010es_ES
dc.identifier1492es_ES
dc.identifier.issn0014-2999es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/6173
dc.identifier.urihttps://doi.org/10.1016/j.ejphar.2010.01.022es_ES
dc.language.isofraes_ES
dc.relation633 (1-3) 39-43 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.subject.meshAging-Psychologyes_ES
dc.subject.meshAnimalses_ES
dc.subject.meshAntidepressive Agents-Therapeutic usees_ES
dc.subject.meshCitalopram-Therapeutic usees_ES
dc.subject.meshDepression-Drug therapyes_ES
dc.subject.meshDisease Models, Animales_ES
dc.subject.meshDrinking-Drug effectses_ES
dc.subject.meshFood Preferences-Drug effectses_ES
dc.subject.meshMalees_ES
dc.subject.meshRatses_ES
dc.subject.meshRats, Wistares_ES
dc.subject.meshStress, Psychological-Drug therapyes_ES
dc.subject.meshStress, Psychological-Psychologyes_ES
dc.subject.meshTime Factorses_ES
dc.subject.meshAntidepressive Agentses_ES
dc.subject.meshCitaloprames_ES
dc.titleAging impairs the antidepressant-like response to citalopram in male ratses_ES
dc.typearticlees_ES
dc.contributor.affiliationFarmacología Conductual, Dirección de Investigaciones en Neurociencias, Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, México City, Mexico.es_ES
dc.contributor.emailjfernand@cinvestav.mxes_ES
dc.relation.jnabreviadoEUR J PHARMACOLes_ES
dc.relation.journalEuropean Journal of Pharmacologyes_ES
dc.identifier.placePaíses Bajoses_ES
dc.date.published2010es_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñizes_ES
dc.identifier.eissn1879-0712es_ES
dc.identifier.doi10.1016/j.ejphar.2010.01.022es_ES
dc.description.monthMayes_ES
dc.description.abstractotrodiomaIt has been suggested that old depressed patients require longer antidepressant treatments than their young counterparts. The objective of this study was to establish if aging impairs the response to an antidepressant by using an animal model. For this purpose, young and middle-aged male Wistar rats (of around 4 and 14months, respectively) were exposed to a chronic mild stress schedule for 3weeks. After this period, the animals that developed anhedonia, reflected as a reduction in sucrose solution (1%) intake, were treated with citalopram (10mg-kg-day) during 21days while still maintained under the chronic mild stress schedule. Non-stressed animals were included as controls. In young rats citalopram reversed the reduction in sucrose consumption induced by chronic mild stress after one week of treatment, while in middle-aged animals a similar reversion occurred after three weeks. Citalopram did not importantly modify simple water intake in stressed animals or sucrose consumption in non-stressed rats of both ages. The results imply that young rats have a lower latency of onset to the antidepressant-like effect of citalopram than middle-aged animals. The lower sensitivity of middle-aged animals to citalopram could be underlied by their lower levels of gonadal hormoneses_ES
dc.subject.kwEnvejecimientoes_ES
dc.subject.kwAnhedoniaes_ES
dc.subject.kwEstrés leve crónicoes_ES
dc.subject.kwCitaloprames_ES
dc.subject.kwDepresiónes_ES
dc.subject.koAginges_ES
dc.subject.koAnhedoniaes_ES
dc.subject.koChronic mild stresses_ES
dc.subject.koCitaloprames_ES
dc.subject.koDepressiones_ES


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