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Summation of excitatory postsynaptic potentials in electrically-coupled neurones

dc.creatorVázquez, Y.
dc.creatorMéndez, B.
dc.creatorTrueta, C.
dc.creatorDe-Miguel, F.F.
dc.date.accessioned2017-06-30T01:36:44Z
dc.date.available2017-06-30T01:36:44Z
dc.date.issued2009es_ES
dc.identifier1484es_ES
dc.identifier.issn0306-4522es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/6165
dc.identifier.urihttps://doi.org/10.1016/j.neuroscience.2009.06.003es_ES
dc.language.isoenges_ES
dc.relation163 (1) 202-212 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.subject.meshAction potentials-Physiologyes_ES
dc.subject.meshAnimalses_ES
dc.subject.meshAxons-Physiologyes_ES
dc.subject.meshCell communication-Physiologyes_ES
dc.subject.meshComputer simulationes_ES
dc.subject.meshDendrites-Physiologyes_ES
dc.subject.meshDendrites-Ultrastructurees_ES
dc.subject.meshElectric stimulationes_ES
dc.subject.meshExcitatory postsynaptic potentials-Physiologyes_ES
dc.subject.meshGanglia, invertebrate-Physiologyes_ES
dc.subject.meshGap junctions-Physiologyes_ES
dc.subject.meshLeecheses_ES
dc.subject.meshModels, Theoreticales_ES
dc.subject.meshNeurons-Physiologyes_ES
dc.subject.meshSignal processing, computer-Assistedes_ES
dc.subject.meshSoftwarees_ES
dc.subject.meshSynaptic transmission-Physiologyes_ES
dc.titleSummation of excitatory postsynaptic potentials in electrically-coupled neuroneses_ES
dc.typearticlees_ES
dc.contributor.affiliationDepartamento de Biofísica, Instituto de Fisiología Celular-Neurociencias, Universidad Nacional Autónoma de México, Apartado Postal 70-253, C.P. 04510, D.F., Mexicoes_ES
dc.contributor.emailffernand@ifc.unam.mxes_ES
dc.relation.jnabreviadoNEUROSCIENCEes_ES
dc.relation.journalNeurosciencees_ES
dc.identifier.placeEstados Unidoses_ES
dc.date.published2009es_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñizes_ES
dc.identifier.eissn1873-7544es_ES
dc.identifier.doi10.1016/j.neuroscience.2009.06.003es_ES
dc.description.monthSepes_ES
dc.description.abstractotrodiomaDendritic electrical coupling increases the number of effective synaptic inputs onto neurones by allowing the direct spread of synaptic potentials from one neurone to another. Here we studied the summation of excitatory postsynaptic potentials (EPSPs) produced locally and arriving from the coupled neurone (transjunctional) in pairs of electrically-coupled Retzius neurones of the leech. We combined paired recordings of EPSPs, the production of artificial excitatory postsynaptic potentials (APSPs) in neurone pairs with different coupling coefficients and simulations of EPSPs produced in the coupled dendrites. Summation of the EPSPs produced in the dendrites was always linear, suggesting that synchronous EPSPs are produced at two or more different pairs of coupled dendrites and not in both sides of any one gap junction. The different spatio-temporal relationships explored between pairs of EPSPs or APSPs produced three main effects. (1) Synchronous pairs of EPSPs or APSPs exhibited an elongation of their decay phase compared to single EPSPs. (2) Asymmetries in the amplitudes between the pair of EPSPs added a "hump" to the smallest EPSP. (3) Modelling the inputs near the electrical synapse or anticipating the production of the transjunctional APSP increased the amplitude of the compound EPSP. The magnitude of all these changes depended on the coupling coefficient of the neurones. We also show that the hump improves the passive conduction of EPSPs by adding low frequency components. The diverse effects of summation of local and alien EPSPs shown here endow electrically-coupled neurones with a wider repertoire of adjustable integrative possibilitieses_ES
dc.subject.kwIntegración sinápticaes_ES
dc.subject.kwPotenciales postsinápticos excitatorios (PPE)es_ES
dc.subject.kwSinapsis eléctricaes_ES
dc.subject.kwSumaes_ES
dc.subject.kwSanguijuelaes_ES
dc.subject.koSynaptic integrationes_ES
dc.subject.koEPSPes_ES
dc.subject.koElectrical synapsees_ES
dc.subject.koSummationes_ES
dc.subject.koLeeches_ES


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