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Temporal lobe epilepsy causes selective changes in mu opioid and nociceptin receptor binding and functional coupling to G-proteins in human temporal neocortex.

dc.creatorRocha, Luisa
dc.creatorOrozco-Suarez, Sandra
dc.creatorAlonso-Vanegas, Mario
dc.creatorVilleda-Hernandez, Juana
dc.creatorGaona, Andrés
dc.creatorPáldy, Eszter
dc.creatorBenyhe, Sandor
dc.creatorBorsodi, Anna
dc.date.accessioned2017-06-30T01:36:28Z
dc.date.available2017-06-30T01:36:28Z
dc.date.issued2009es_ES
dc.identifier1482es_ES
dc.identifier.issn0969-9961es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/6163
dc.identifier.urihttps://doi.org/10.1016/j.nbd.2009.06.008es_ES
dc.language.isoenges_ES
dc.relation35 (3) 466-473 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.subject.meshAdenylate Cyclase-Metabolismes_ES
dc.subject.meshAdultes_ES
dc.subject.meshCentral Nervous System Agents-Pharmacologyes_ES
dc.subject.meshEnkephalin, Ala(2)-MePhe(4)-Gly(5)-Metabolismes_ES
dc.subject.meshEpilepsy, Temporal Lobe-Metabolismes_ES
dc.subject.meshFemalees_ES
dc.subject.meshForskolin-Pharmacologyes_ES
dc.subject.meshGTP-Binding Proteins-Metabolismes_ES
dc.subject.meshGuanosine 5'-O-(3-Thiotriphosphate)-Metabolismes_ES
dc.subject.meshHumanses_ES
dc.subject.meshMalees_ES
dc.subject.meshMiddle Agedes_ES
dc.subject.meshNeocortex-Metabolismes_ES
dc.subject.meshOpioid Peptides-Metabolismes_ES
dc.subject.meshReceptors, Opioid-Metabolismes_ES
dc.subject.meshReceptors, Opioid, mu-Metabolismes_ES
dc.subject.meshSulfur Radioisotopeses_ES
dc.subject.meshTemporal Lobe-Metabolismes_ES
dc.subject.meshTritiumes_ES
dc.subject.meshYoung Adultes_ES
dc.subject.meshCentral Nervous System Agentses_ES
dc.subject.meshOpioid Peptideses_ES
dc.subject.meshReceptors, Opioides_ES
dc.subject.meshReceptors, Opioid, mues_ES
dc.subject.meshOPRM1 protein, humanes_ES
dc.subject.meshSulfur Radioisotopeses_ES
dc.subject.meshNociceptines_ES
dc.subject.meshNociceptin receptores_ES
dc.subject.meshTritiumes_ES
dc.subject.meshEnkephalin, Ala(2)-MePhe(4)-Gly(5)es_ES
dc.subject.meshGuanosine 5'-O-(3-Thiotriphosphate)es_ES
dc.subject.meshForskolines_ES
dc.subject.meshGTP-Binding Proteinses_ES
dc.titleTemporal lobe epilepsy causes selective changes in mu opioid and nociceptin receptor binding and functional coupling to G-proteins in human temporal neocortex.es_ES
dc.typearticlees_ES
dc.contributor.affiliationDepartment of Pharmacobiology, Center of Research and Advanced Studies, Mexico City, Mexicoes_ES
dc.contributor.emaillrocha@cinvestav.mxes_ES
dc.relation.jnabreviadoNEUROBIOL DISes_ES
dc.relation.journalNeurobiology of Diseasees_ES
dc.identifier.placeEstados Unidoses_ES
dc.date.published2009es_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñizes_ES
dc.identifier.eissn1095-953Xes_ES
dc.identifier.doi10.1016/j.nbd.2009.06.008es_ES
dc.description.monthSepes_ES
dc.description.abstractotrodiomaThere is no information concerning signal transduction mechanisms downstream of the opioid/nociceptin receptors in the human epileptic brain. The aim of this work was to evaluate the level of G-proteins activation mediated by DAMGO (a mu receptor selective peptide) and nociceptin, and the binding to mu and nociceptin (NOP) receptors and adenylyl cyclase (AC) in neocortex of patients with pharmacoresistant temporal lobe epilepsy. Patients with temporal lobe epilepsy associated with mesial sclerosis (MTLE) or secondary to tumor or vascular lesion showed enhanced [3H]DAMGO and [3H]forskolin binding, lower DAMGO-stimulated [35S]GTPgammaS binding and no significant changes in nociceptin-stimulated G-protein. [3H]Nociceptin binding was lower in patients with MTLE. Age of seizure onset correlated positively with [3H]DAMGO binding and DAMGO-stimulated [35S]GTPgammaS binding, whereas epilepsy duration correlated negatively with [3H]DAMGO and [3H]nociceptin binding, and positively with [3H]forskolin binding. In conclusion, our present data obtained from neocortex of epileptic patients provide strong evidence that a) temporal lobe epilepsy is associated with alterations in mu opioid and NOP receptor binding and signal transduction mechanisms downstream of these receptors, and b) clinical aspects may play an important role on these receptor changeses_ES
dc.subject.kwReceptor opioide mues_ES
dc.subject.kwReceptor de nociceptinaes_ES
dc.subject.kwProteína Ges_ES
dc.subject.kw[35S] GTPyS de uniónes_ES
dc.subject.kwAdenilato ciclasaes_ES
dc.subject.kwEpilepsia del lóbulo temporal mesiales_ES
dc.subject.kwNeocórtexes_ES
dc.subject.koMu opiod receptores_ES
dc.subject.koNociceptin receptores_ES
dc.subject.koG-proteines_ES
dc.subject.ko[35S]GTP_S bindinges_ES
dc.subject.koAdenylyl cyclasees_ES
dc.subject.koMesial temporal lobe epilepsyes_ES
dc.subject.koNeocortexes_ES


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