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Quantitative morphometry of electrophysiologically identified CA3b interneurons reveals robust local geometry and distinct cell classes

dc.creatorAscoli, Giorgio A.
dc.creatorBrown, Kerry M.
dc.creatorCalixto, Eduardo
dc.creatorCard, J. Patrick
dc.creatorGalván, E.J.
dc.creatorPérez-Rosello, T.
dc.creatorBarrionuevo, Germán
dc.date.accessioned2017-06-30T01:35:56Z
dc.date.available2017-06-30T01:35:56Z
dc.date.issued2009es_ES
dc.identifier1478es_ES
dc.identifier.issn0021-9967es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/6159
dc.identifier.urihttps://doi.org/10.1002/cne.22082es_ES
dc.identifier.urihttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2827149/es_ES
dc.language.isoenges_ES
dc.relation515 (6) 677-695 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.subject.meshAnimalses_ES
dc.subject.meshAxons-Ultrastructurees_ES
dc.subject.meshDendrites-Ultrastructurees_ES
dc.subject.meshExcitatory Postsynaptic Potentialses_ES
dc.subject.meshHippocampus-Cytologyes_ES
dc.subject.meshInterneurons-Classificationes_ES
dc.subject.meshInterneurons-Cytologyes_ES
dc.subject.meshInterneurons-Metabolismes_ES
dc.subject.meshMalees_ES
dc.subject.meshNeuronal plasticity-Physiologyes_ES
dc.subject.meshPatch-Clamp Techniqueses_ES
dc.subject.meshRatses_ES
dc.subject.meshRats, Sprague-Dawleyes_ES
dc.subject.meshReceptors, AMPA-Metabolismes_ES
dc.subject.meshReceptors, AMPAes_ES
dc.titleQuantitative morphometry of electrophysiologically identified CA3b interneurons reveals robust local geometry and distinct cell classeses_ES
dc.typearticlees_ES
dc.contributor.affiliationCenter for Neural Informatics, Structures, & Plasticity, and Molecular Neuroscience Department, Krasnow Institute for Advanced Study, George Mason University, 4400 University Drive, Fairfax, VA 22030-4444, USAes_ES
dc.contributor.emailascoli@gmu.edues_ES
dc.relation.jnabreviadoJ COMP NEUROLes_ES
dc.relation.journalThe Journal of Comparative Neurologyes_ES
dc.identifier.placeEstados Unidoses_ES
dc.date.published2009es_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñizes_ES
dc.identifier.eissn1096-9861es_ES
dc.identifier.doi10.1002/cne.22082es_ES
dc.description.monthAgoes_ES
dc.description.abstractotrodiomaThe morphological and electrophysiological diversity of inhibitory cells in hippocampal area CA3 may underlie specific computational roles and is not yet fully elucidated. In particular, interneurons with somata in strata radiatum (R) and lacunosum-moleculare (L-M) receive converging stimulation from the dentate gyrus and entorhinal cortex as well as within CA3. Although these cells express different forms of synaptic plasticity, their axonal trees and connectivity are still largely unknown. We investigated the branching and spatial patterns, plus the membrane and synaptic properties, of rat CA3b R and L-M interneurons digitally reconstructed after intracellular labeling. We found considerable variability within but no difference between the two layers, and no correlation between morphological and biophysical properties. Nevertheless, two cell types were identified based on the number of dendritic bifurcations, with significantly different anatomical and electrophysiological features. Axons generally branched an order of magnitude more than dendrites. However, interneurons on both sides of the R-L-M boundary revealed surprisingly modular axodendritic arborizations with consistently uniform local branch geometry. Both axons and dendrites followed a lamellar organization, and axons displayed a spatial preference toward the fissure. Moreover, only a small fraction of the axonal arbor extended to the outer portion of the invaded volume, and tended to return toward the proximal region. In contrast, dendritic trees demonstrated more limited but isotropic volume occupancy. These results suggest a role of predominantly local feedforward and lateral inhibitory control for both R and L-M interneurons. Such a role may be essential to balance the extensive recurrent excitation of area CA3 underlying hippocampal autoassociative memory function.es_ES
dc.subject.kwAxoneses_ES
dc.subject.kwDerivaciónes_ES
dc.subject.kwDendritases_ES
dc.subject.kwInhibición de alimentación directaes_ES
dc.subject.kwHipocampoes_ES
dc.subject.kwInhibición laterales_ES
dc.subject.kwEstrato lacunosum-molecularees_ES
dc.subject.kwEstrato radiatumes_ES
dc.subject.koAxonses_ES
dc.subject.koBranchinges_ES
dc.subject.koDendriteses_ES
dc.subject.koHippocampuses_ES
dc.subject.koLateral inhibitiones_ES
dc.subject.koStratum lacunosum-molecularees_ES
dc.subject.koStratum radiatumes_ES
dc.subject.koFeed forward inhibitiones_ES


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