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Tanycyte pyroglutamyl peptidase II contributes to regulation of the hypothalamic-pituitary-thyroid axis through glial-axonal associations in the median eminence

dc.creatorSánchez, Edith
dc.creatorVargas, Miguel Ángel
dc.creatorSingru, Praful S.
dc.creatorPascual, Isel
dc.creatorRomero, Fidelia
dc.creatorFekete, Csaba
dc.creatorCharli, Jean-Louis
dc.creatorLechan, Ronald M.
dc.date.accessioned2017-06-30T01:35:49Z
dc.date.available2017-06-30T01:35:49Z
dc.date.issued2009es_ES
dc.identifier1477es_ES
dc.identifier.issn0013-7227es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/6158
dc.identifier.urihttps://doi.org/10.1210/en.2008-1643es_ES
dc.identifier.urihttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2671897/es_ES
dc.language.isoenges_ES
dc.relation150 (5) 2283-2291 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.subject.meshAminopeptidases-Geneticses_ES
dc.subject.meshAminopeptidases-Metabolismes_ES
dc.subject.meshAminopeptidases-Physiologyes_ES
dc.subject.meshAnimalses_ES
dc.subject.meshAxons-Metabolismes_ES
dc.subject.meshAxons-Physiologyes_ES
dc.subject.meshCell Communication-Physiologyes_ES
dc.subject.meshGene expression regulation, Enzymologic-Drug effectses_ES
dc.subject.meshHypothalamo-Hypophyseal System-Metabolismes_ES
dc.subject.meshHypothalamo-Hypophyseal System-Physiologyes_ES
dc.subject.meshMalees_ES
dc.subject.meshMedian eminence-Cytologyes_ES
dc.subject.meshMedian eminence-Enzymologyes_ES
dc.subject.meshMedian eminence-Innervationes_ES
dc.subject.meshModels, Biologicales_ES
dc.subject.meshNeuroglia-Cytologyes_ES
dc.subject.meshNeuroglia-Drug effectses_ES
dc.subject.meshNeuroglia-Metabolismes_ES
dc.subject.meshNeuroglia-Physiologyes_ES
dc.subject.meshProtein precursors-Metabolismes_ES
dc.subject.meshPyrrolidonecarboxylic acid-Analogs & derivativeses_ES
dc.subject.meshPyrrolidonecarboxylic acid-Metabolismes_ES
dc.subject.meshRNA, Messenger-Metabolismes_ES
dc.subject.meshRatses_ES
dc.subject.meshRats, Sprague-Dawleyes_ES
dc.subject.meshThyroid gland-Metabolismes_ES
dc.subject.meshThyroid gland-Physiologyes_ES
dc.subject.meshThyrotropin-Bloodes_ES
dc.subject.meshThyrotropin-releasing hormone-Metabolismes_ES
dc.subject.meshThyroxine-Pharmacologyes_ES
dc.subject.meshTissue distributiones_ES
dc.subject.meshProtein precursorses_ES
dc.subject.meshRNA, Messengeres_ES
dc.subject.meshThyrotropin-releasing hormonees_ES
dc.subject.meshThyroxinees_ES
dc.subject.meshThyrotropines_ES
dc.subject.meshPyrrolidonecarboxylic Acides_ES
dc.subject.meshPro-thyrotropin releasing hormonees_ES
dc.subject.meshAminopeptidaseses_ES
dc.subject.meshPyroglutamyl-peptidase IIes_ES
dc.titleTanycyte pyroglutamyl peptidase II contributes to regulation of the hypothalamic-pituitary-thyroid axis through glial-axonal associations in the median eminencees_ES
dc.typearticlees_ES
dc.contributor.affiliationTupper Research Institute and Department of Medicine, Division of Endocrinology, Diabetes, and Metabolism, Tufts Medical Center, 750 Washington Street, Boston, Massachusetts 02111, USAes_ES
dc.contributor.emailrlechan@tuftsmedicalcenter.org.es_ES
dc.relation.jnabreviadoENDOCRINOLOGYes_ES
dc.relation.journalEndocrinologyes_ES
dc.identifier.placeEstados Unidoses_ES
dc.date.published2009es_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñizes_ES
dc.identifier.eissn1945-7170es_ES
dc.identifier.doi10.1210/en.2008-1643es_ES
dc.description.monthMayes_ES
dc.description.abstractotrodiomaPyroglutamyl peptidase II (PPII), a highly specific membrane-bound metallopeptidase that inactivates TRH in the extracellular space, is tightly regulated by thyroid hormone in cells of the anterior pituitary. Whether PPII has any role in the region where axons containing hypophysiotropic TRH terminate, the median eminence, is unknown. For this purpose, we analyzed the cellular localization and regulation of PPII mRNA in the mediobasal hypothalamus in adult, male rats. PPII mRNA was localized in cells lining the floor and infralateral walls of the third ventricle and coexpressed with vimentin, establishing these cells as tanycytes. PPII mRNA extended in a linear fashion from the tanycyte cell bodies in the base of the third ventricle to its cytoplasmic and end-feet processes in the external zone of the median eminence in close apposition to pro-TRH-containing axon terminals. Compared with vehicle-treated, euthyroid controls, animals made thyrotoxic by the i.p. administration of 10 microg L-T(4) daily for 1-3 d, showed dramatically increased accumulation of silver grains in the mediobasal hypothalamus and an approximately 80% increase in enzymatic activity. PPII inhibition in mediobasal hypothalamic explants increased TRH secretion, whereas i.p. injection of a specific PPII inhibitor increased cold stress- and TRH-induced TSH levels in plasma. We propose that an increase in circulating thyroid hormone up-regulates PPII activity in tanycytes and enhances degradation of extracellular TRH in the median eminence through glial-axonal associations, contributing to the feedback regulation of thyroid hormone on anterior pituitary TSH secretiones_ES
dc.subject.kwTanycyte piroglutamil peptidasa IIes_ES
dc.subject.kwEje hipotálamo-hipófisis-tiroideses_ES
dc.subject.kwAsociaciones-gliales axonales_ES
dc.subject.kwEminencia mediaes_ES
dc.subject.koTanycyte pyroglutamyl peptidase IIes_ES
dc.subject.koHypothalamic-pituitary-thyroid axises_ES
dc.subject.koGlial-axonal associationses_ES
dc.subject.koMedian eminencees_ES


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