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Differential response of TRHergic neurons of the hypothalamic paraventricular nucleus (PVN) in female animals submitted to food-restriction or dehydration-induced anorexia and cold exposure

dc.creatorJaimes-Hoy, Lorraine
dc.creatorJoseph-Bravo, Patricia
dc.creatorGortari, Patricia de
dc.date.accessioned2017-06-30T01:35:33Z
dc.date.available2017-06-30T01:35:33Z
dc.date.issued2008es_ES
dc.identifier1475es_ES
dc.identifier.issn0018-506Xes_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/6156
dc.identifier.urihttps://doi.org/10.1016/j.yhbeh.2007.11.003es_ES
dc.language.isoenges_ES
dc.relation53 (2) 366-377 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.titleDifferential response of TRHergic neurons of the hypothalamic paraventricular nucleus (PVN) in female animals submitted to food-restriction or dehydration-induced anorexia and cold exposurees_ES
dc.typearticlees_ES
dc.contributor.affiliationDivisión de Investigaciones en Neurociencias, Instituto Nacional de Psiquiatría RFM, México D.F., México.es_ES
dc.contributor.emailgortari@imp.edu.mxes_ES
dc.relation.jnabreviadoHORM BEHAVes_ES
dc.relation.journalHormones and Behaviores_ES
dc.date.published2008es_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñizes_ES
dc.identifier.eissn1095-6867es_ES
dc.identifier.doi10.1016/j.yhbeh.2007.11.003es_ES
dc.description.monthFebes_ES
dc.description.abstractotrodiomaTRH neurons of the hypothalamic paraventricular nucleus (PVN), regulate pituitary-thyroid axis (HPT). Fasting activates expression of orexigenic peptides from the arcuate nucleus, increases corticosterone while reduces leptin, and pro-TRH mRNA levels despite low serum thyroid hormone concentration (tertiary hypothyroidism). TRH synthesis is positively regulated by anorexigenic peptides whose expression is reduced in fasting. The model of dehydration-induced anorexia (DIA) leads to decreased voluntary food intake but peptide expression in the arcuate is similar to forced-food restriction (FFR), where animals remain hungered. We compared the response of HPT axis of female Wistar rats submitted to DIA (2.5% saline solution, food ad libitum, 7 days) with FFR (provided with the amount of food ingested by DIA) and naïve (N) group fed ad libitum, as well as their response to acute cold exposure. Pro-TRH and pro-CRH mRNA levels in the PVN were measured by RT-PCR, TRH content, serum concentration of TSH and thyroid hormones by radioimmunoassay. DIA rats reduced 80% their food consumption compared to N, decreased PVN pro-CRH expression, serum estradiol and leptin levels, increased corticosterone similar to FFR. HPT axis of DIA animals failed to adapt: FFR presented tertiary hypothyroidism and DIA, primary. Response to cold stimulation leading to increased pro-TRH mRNA levels and TRH release was preserved under reduced energy availability in FFR rats but not in DIA, although the dynamics of hormonal release differed: TSH release augmented only in naïve; thyroxine in all but highest in DIA, and triiodothyronine in FFR and DIA suggesting a differential regulation of deiodinases.es_ES
dc.subject.koAdaptation, Physiologicales_ES
dc.subject.koAminopeptidaseses_ES
dc.subject.kometabolismes_ES
dc.subject.koAnimalses_ES
dc.subject.koAnorexiaes_ES
dc.subject.koetiologyes_ES
dc.subject.koAnorexiaes_ES
dc.subject.kometabolismes_ES
dc.subject.koAnxietyes_ES
dc.subject.kocomplicationses_ES
dc.subject.koAnxietyes_ES
dc.subject.kometabolismes_ES
dc.subject.koAppetite Regulationes_ES
dc.subject.kophysiologyes_ES
dc.subject.koBody Compositiones_ES
dc.subject.koCold Temperaturees_ES
dc.subject.koCorticosteronees_ES
dc.subject.kobloodes_ES
dc.subject.koDehydrationes_ES
dc.subject.kocomplicationses_ES
dc.subject.koDehydrationes_ES
dc.subject.kometabolismes_ES
dc.subject.koDisease Models, Animales_ES
dc.subject.koFemalees_ES
dc.subject.koFood Deprivationes_ES
dc.subject.kophysiologyes_ES
dc.subject.koHypothalamo-Hypophyseal Systemes_ES
dc.subject.kometabolismes_ES
dc.subject.koMatched-Pair Analysises_ES
dc.subject.koNeuronses_ES
dc.subject.kometabolismes_ES
dc.subject.koParaventricular Hypothalamic Nucleuses_ES
dc.subject.kocytologyes_ES
dc.subject.koParaventricular Hypothalamic Nucleuses_ES
dc.subject.kometabolismes_ES
dc.subject.koPituitary Gland, Anteriores_ES
dc.subject.kometabolismes_ES
dc.subject.koProtein Precursorses_ES
dc.subject.kometabolismes_ES
dc.subject.koPyrrolidonecarboxylic Acides_ES
dc.subject.koanalogs & derivativeses_ES
dc.subject.koPyrrolidonecarboxylic Acides_ES
dc.subject.kometabolismes_ES
dc.subject.koRNA, Messengeres_ES
dc.subject.koanalysises_ES
dc.subject.koRatses_ES
dc.subject.koRats, Wistares_ES
dc.subject.koReceptors, Thyrotropin-Releasing Hormonees_ES
dc.subject.kogeneticses_ES
dc.subject.koReceptors, Thyrotropin-Releasing Hormonees_ES
dc.subject.kometabolismes_ES
dc.subject.koSex Factorses_ES
dc.subject.koStress, Physiologicales_ES
dc.subject.kocomplicationses_ES
dc.subject.koStress, Physiologicales_ES
dc.subject.kometabolismes_ES
dc.subject.koThyroid Glandes_ES
dc.subject.kometabolismes_ES
dc.subject.koThyroid Hormoneses_ES
dc.subject.kobloodes_ES
dc.subject.koThyrotropin-Releasing Hormonees_ES
dc.subject.kometabolismes_ES
dc.subject.koProtein Precursorses_ES
dc.subject.koRNA, Messengeres_ES
dc.subject.koReceptors, Thyrotropin-Releasing Hormonees_ES
dc.subject.koThyroid Hormoneses_ES
dc.subject.koThyrotropin-Releasing Hormonees_ES
dc.subject.koCorticosteronees_ES
dc.subject.koPyrrolidonecarboxylic Acides_ES
dc.subject.koAminopeptidaseses_ES
dc.subject.kopyroglutamyl-peptidase IIes_ES


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