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The expression of TRH, its receptors and degrading enzyme is differentially modulated in the rat limbic system during training in the Morris water maze

dc.creatorAguilar-Valles, Argel
dc.creatorSánchez, Edith
dc.creatorGortari, Patricia de
dc.creatorGarcía-Vázquez, Arlene I.
dc.creatorRamírez-Amaya, Víctor
dc.creatorBermúdez-Rattoni, Federico
dc.creatorJoseph-Bravo, Patricia
dc.date.accessioned2017-06-30T01:35:13Z
dc.date.available2017-06-30T01:35:13Z
dc.date.issued2007es_ES
dc.identifier1473es_ES
dc.identifier.issn0197-0186es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/6154
dc.identifier.urihttps://doi.org/10.1016/j.neuint.2006.09.009es_ES
dc.language.isoenges_ES
dc.relation50 (2) 404-417 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.titleThe expression of TRH, its receptors and degrading enzyme is differentially modulated in the rat limbic system during training in the Morris water mazees_ES
dc.typearticlees_ES
dc.contributor.affiliationDepartamento de Genética del Desarrollo y Fisiología Molecular, Instituto de Biotecnología, Universidad Nacional Autónoma de México (UNAM), A.P. 510-3, Cuernavaca 62210, Morelos, México.es_ES
dc.contributor.emailjoseph@ibt.unam.mxes_ES
dc.relation.jnabreviadoNEUROCHEM INTes_ES
dc.relation.journalNeurochemistry Internationales_ES
dc.identifier.placeInglaterraes_ES
dc.date.published2007es_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñizes_ES
dc.identifier.eissn1872-9754es_ES
dc.identifier.doi10.1016/j.neuint.2006.09.009es_ES
dc.description.monthEnees_ES
dc.description.abstractotrodiomaTRH administration induces arousal, improves cognition, and modulates glutamatergic and cholinergic transmission in hippocampal neurons. To study the possible involvement of TRH neurons in learning and memory processes, gene expression of TRH, its receptors, and pyroglutamyl peptidase (PPII), were measured in limbic regions of water-maze trained rats. Hypothalamus and amygdala showed changes related to the task but not specific to spatial learning while in hippocampus, pro-TRH and TRH-R1 mRNA levels were specifically increased in those animals trained to find a hidden platform. Variation of TRH content and mRNA levels of pro-TRH, TRH-R1, TRH-R2 and PPII are observed in conditions known to activate TRH hypophysiotropic neurons. Changes in some of these parameters could indicate the activation of TRHergic neurons and their possible involvement in some memory related process. Male Wistar rats were immersed (10 times) for 1, 3 or 5 days in a Morris water-maze containing, or not (yoked control) a platform and sacrificed 5, 30 and 60 min after last trial. TRH content and TSH serum levels were determined by radioimmunoassay; mRNA levels of pro-TRH, TRH-R1, TRH-R2, and PPII, by RT-PCR. Exclusive changes due to spatial training were observed in posterior hippocampus of rats trained for 5 days sacrificed after 60min: decreased TRH content and increased mRNA levels of pro-TRH and TRH-R1, particularly in CA3 region (measured by in situ hybridization). The hypothalamus-pituitary axis responded in both yoked and trained animals (increasing serum TSH levels and pro-TRH expression, due to swim-stress); in the amygdala of both groups, pro-TRH expression increased while diminished that of both receptors and PPII. Differential expression of these parameters suggests involvement of TRH hippocampal neurons in memory formation processes while changes in amygdala could relate to TRH anxiolytic role. The differential modulation in anterior and posterior portions of the hippocampus is discussedes_ES
dc.subject.koAnimalses_ES
dc.subject.koAutoradiographyes_ES
dc.subject.koHippocampuses_ES
dc.subject.kometabolismes_ES
dc.subject.koHypothalamo-Hypophyseal Systemes_ES
dc.subject.kometabolismes_ES
dc.subject.koIn Situ Hybridizationes_ES
dc.subject.koLimbic Systemes_ES
dc.subject.koenzymologyes_ES
dc.subject.koLimbic Systemes_ES
dc.subject.kometabolismes_ES
dc.subject.koMalees_ES
dc.subject.koMaze Learninges_ES
dc.subject.kophysiologyes_ES
dc.subject.koMemoryes_ES
dc.subject.kophysiologyes_ES
dc.subject.koPyroglutamyl-Peptidase Ies_ES
dc.subject.kometabolismes_ES
dc.subject.koRNA, Messengeres_ES
dc.subject.kobiosynthesises_ES
dc.subject.koRadioimmunoassayes_ES
dc.subject.koRatses_ES
dc.subject.koRats, Wistares_ES
dc.subject.koReceptors, Thyrotropines_ES
dc.subject.kobiosynthesises_ES
dc.subject.koReverse Transcriptase Polymerase Chain Reactiones_ES
dc.subject.koThyroid Glandes_ES
dc.subject.kometabolismes_ES
dc.subject.koThyrotropines_ES
dc.subject.kobiosynthesises_ES
dc.subject.koRNA, Messengeres_ES
dc.subject.koReceptors, Thyrotropines_ES
dc.subject.koThyrotropines_ES
dc.subject.koPyroglutamyl-Peptidase Ies_ES


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